Gastrointestinal Cancers and Personalized Medicine
Gastrointestinal cancers, such as esophageal and gastric cancers, pancreatic cancers, hepatobiliary cancers, colorectal cancers and gastrointestinal stromal tumors, are frequently diagnosed at an advanced stage and have a dismal prognosis. Even in patients with potentially curative cancer, nearly 50...
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| Formato: | Online |
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| Idioma: | inglés |
| Publicado: |
MDPI - Multidisciplinary Digital Publishing Institute
2022
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| Subjects: | |
| Acceso en liña: | ONIX_20220506_9783036538082_34 |
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| _version_ | 1869524166843039744 |
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| collection | Directory of Open Access Books |
| description | Gastrointestinal cancers, such as esophageal and gastric cancers, pancreatic cancers, hepatobiliary cancers, colorectal cancers and gastrointestinal stromal tumors, are frequently diagnosed at an advanced stage and have a dismal prognosis. Even in patients with potentially curative cancer, nearly 50\% will develop recurrent disease despite aggressive treatments. A number of biomarkers currently guide treatment decisions for patients with gastrointestinal neoplasms. Major technological advances in genomics have made it possible to identify critical genetic alterations in cancer, furthering oncology along the path to “personalized cancer medicine”. Future research efforts will focus on the identification of new biomarkers, moving existing biomarkers into earlier lines of therapy and evaluating new combinations of existing biomarkers and therapies.The aim of this Special Issue is to provide an overview of exciting new research in the area of gastrointestinal tumors that may establish innovative personalized management and precision medicine modalities for individualized care. |
| format | Online |
| id | doab-20.500.12854ir-80968 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2022 |
| publishDateRange | 2022 |
| publishDateSort | 2022 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-809682024-03-31T13:08:12Z Gastrointestinal Cancers and Personalized Medicine Mini, Enrico Nobili, Stefania neutrophil-to-lymphocyte ratio lymphocyte-to-monocyte ratio prognosis rectal cancer mesorectum sphincter preserving molecular oncology precision medicine colorectal cancer targeted therapy molecular profiling pancreatic cysts thermal liquid biopsy differential scanning calorimetry diagnosis generalized linear models gene signature mRNA expression VANGL1 FFPE neurotoxicity oxaliplatin chemotherapy-induced peripheral neuropathy biomarker genomics neuropathy FOLFOX FOLFIRINOX XELOX gastrointestinal cancer LAG-3 immune checkpoint colon cancer survival microsatellite instability immunotherapy n/a thema EDItEUR::M Medicine and Nursing thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology Gastrointestinal cancers, such as esophageal and gastric cancers, pancreatic cancers, hepatobiliary cancers, colorectal cancers and gastrointestinal stromal tumors, are frequently diagnosed at an advanced stage and have a dismal prognosis. Even in patients with potentially curative cancer, nearly 50\% will develop recurrent disease despite aggressive treatments. A number of biomarkers currently guide treatment decisions for patients with gastrointestinal neoplasms. Major technological advances in genomics have made it possible to identify critical genetic alterations in cancer, furthering oncology along the path to “personalized cancer medicine”. Future research efforts will focus on the identification of new biomarkers, moving existing biomarkers into earlier lines of therapy and evaluating new combinations of existing biomarkers and therapies.The aim of this Special Issue is to provide an overview of exciting new research in the area of gastrointestinal tumors that may establish innovative personalized management and precision medicine modalities for individualized care. 2022-05-06T11:18:47Z 2022-05-06T11:18:47Z 2022 book ONIX_20220506_9783036538082_34 9783036538082 9783036538075 https://directory.doabooks.org/handle/20.500.12854/80968 eng image/jpeg Attribution 4.0 International https://mdpi.com/books/pdfview/book/5308 https://mdpi.com/books/pdfview/book/5308 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-0365-3807-5 10.3390/books978-3-0365-3807-5 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783036538082 9783036538075 136 Basel open access |
| spellingShingle | neutrophil-to-lymphocyte ratio lymphocyte-to-monocyte ratio prognosis rectal cancer mesorectum sphincter preserving molecular oncology precision medicine colorectal cancer targeted therapy molecular profiling pancreatic cysts thermal liquid biopsy differential scanning calorimetry diagnosis generalized linear models gene signature mRNA expression VANGL1 FFPE neurotoxicity oxaliplatin chemotherapy-induced peripheral neuropathy biomarker genomics neuropathy FOLFOX FOLFIRINOX XELOX gastrointestinal cancer LAG-3 immune checkpoint colon cancer survival microsatellite instability immunotherapy n/a thema EDItEUR::M Medicine and Nursing thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology Gastrointestinal Cancers and Personalized Medicine |
| title | Gastrointestinal Cancers and Personalized Medicine |
| title_full | Gastrointestinal Cancers and Personalized Medicine |
| title_fullStr | Gastrointestinal Cancers and Personalized Medicine |
| title_full_unstemmed | Gastrointestinal Cancers and Personalized Medicine |
| title_short | Gastrointestinal Cancers and Personalized Medicine |
| title_sort | gastrointestinal cancers and personalized medicine |
| topic | neutrophil-to-lymphocyte ratio lymphocyte-to-monocyte ratio prognosis rectal cancer mesorectum sphincter preserving molecular oncology precision medicine colorectal cancer targeted therapy molecular profiling pancreatic cysts thermal liquid biopsy differential scanning calorimetry diagnosis generalized linear models gene signature mRNA expression VANGL1 FFPE neurotoxicity oxaliplatin chemotherapy-induced peripheral neuropathy biomarker genomics neuropathy FOLFOX FOLFIRINOX XELOX gastrointestinal cancer LAG-3 immune checkpoint colon cancer survival microsatellite instability immunotherapy n/a thema EDItEUR::M Medicine and Nursing thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology |
| topic_facet | neutrophil-to-lymphocyte ratio lymphocyte-to-monocyte ratio prognosis rectal cancer mesorectum sphincter preserving molecular oncology precision medicine colorectal cancer targeted therapy molecular profiling pancreatic cysts thermal liquid biopsy differential scanning calorimetry diagnosis generalized linear models gene signature mRNA expression VANGL1 FFPE neurotoxicity oxaliplatin chemotherapy-induced peripheral neuropathy biomarker genomics neuropathy FOLFOX FOLFIRINOX XELOX gastrointestinal cancer LAG-3 immune checkpoint colon cancer survival microsatellite instability immunotherapy n/a thema EDItEUR::M Medicine and Nursing thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology |
| url | ONIX_20220506_9783036538082_34 |