Redox Imbalance and Mitochondrial Abnormalities in Kidney Disease
The kidney performs important functions in the human body and can inflict either acute kidney injury (AKI) or chronic kidney disease (CKD). AKI can be induced by kidney ischemia, drugs such as cisplatin, and heavy metals such as cadmium and arsenic. CKD can be induced by drugs, heavy metals, hyperte...
I tiakina i:
| Hōputu: | Online |
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| Reo: | Ingarihi |
| I whakaputaina: |
MDPI - Multidisciplinary Digital Publishing Institute
2022
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| Ngā marau: | |
| Urunga tuihono: | ONIX_20220506_9783036537573_85 |
| Ngā Tūtohu: |
Kāore He Tūtohu, Me noho koe te mea tuatahi ki te tūtohu i tēnei pūkete!
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| _version_ | 1869529195830312960 |
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| collection | Directory of Open Access Books |
| description | The kidney performs important functions in the human body and can inflict either acute kidney injury (AKI) or chronic kidney disease (CKD). AKI can be induced by kidney ischemia, drugs such as cisplatin, and heavy metals such as cadmium and arsenic. CKD can be induced by drugs, heavy metals, hypertension, and diabetes, as well as cancer. Importantly, nearly all kidney disorders have been shown to involve redox imbalance, reductive stress, oxidative stress, and mitochondrial abnormalities such as impaired mitochondrial homeostasis, including disrupted mitophagy and deranged mitochondrial unfolded protein responses. Understanding how these redox-related dysregulated pathways operate may give us new insights into how to design novel approaches to fighting kidney disease. This Special Issue of Biomolecules entitled “Redox imbalance and mitochondrial abnormalities in kidney disease” covers a variety of topics focusing on oxidative stress, mitochondrial dysfunction, and antioxidation enhancement implicated in kidney disease or kidney transplantation. |
| format | Online |
| id | doab-20.500.12854ir-81019 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2022 |
| publishDateRange | 2022 |
| publishDateSort | 2022 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-810192024-03-31T13:08:14Z Redox Imbalance and Mitochondrial Abnormalities in Kidney Disease Yan, Liang-Jun diabetic kidney disease caloric restriction NADH/NAD+ redox imbalance mitochondrial homeostasis mitophagy oxidative stress kidney allograft kidney rejection ischemia acute kidney injury (AKI) chronic kidney disease (CKD) tricarboxylic acid (TCA) cycle mitochondrial metabolism mitochondrial redox signaling mitochondrial proteins oxidative phosphorylation (OXPHOS) fatty acid (FA) β-oxidation mitochondrial dynamics biogenesis diabetes kidney mitochondria Oryza sativa rice husk TCA cycle metabolites kidney diseases renalase chronic kidney disease major adverse cardiovascular outcomes cadmium kidney injury renal toxicity oxidative damage proximal tubule controlled oxygenated rewarming mitochondrial uncoupling rewarming injury temperature paradox redox mitochondrial dysfunction SGLT2 mitochondrial reactive oxygen species Warburg effect podocytopathies mitochondrial oxidative stress reactive oxygen species (ROS) antioxidant defense cell death n/a thema EDItEUR::M Medicine and Nursing thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology The kidney performs important functions in the human body and can inflict either acute kidney injury (AKI) or chronic kidney disease (CKD). AKI can be induced by kidney ischemia, drugs such as cisplatin, and heavy metals such as cadmium and arsenic. CKD can be induced by drugs, heavy metals, hypertension, and diabetes, as well as cancer. Importantly, nearly all kidney disorders have been shown to involve redox imbalance, reductive stress, oxidative stress, and mitochondrial abnormalities such as impaired mitochondrial homeostasis, including disrupted mitophagy and deranged mitochondrial unfolded protein responses. Understanding how these redox-related dysregulated pathways operate may give us new insights into how to design novel approaches to fighting kidney disease. This Special Issue of Biomolecules entitled “Redox imbalance and mitochondrial abnormalities in kidney disease” covers a variety of topics focusing on oxidative stress, mitochondrial dysfunction, and antioxidation enhancement implicated in kidney disease or kidney transplantation. 2022-05-06T11:22:07Z 2022-05-06T11:22:07Z 2022 book ONIX_20220506_9783036537573_85 9783036537573 9783036537580 https://directory.doabooks.org/handle/20.500.12854/81019 eng image/jpeg Attribution 4.0 International https://mdpi.com/books/pdfview/book/5361 https://mdpi.com/books/pdfview/book/5361 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-0365-3758-0 10.3390/books978-3-0365-3758-0 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783036537573 9783036537580 200 Basel open access |
| spellingShingle | diabetic kidney disease caloric restriction NADH/NAD+ redox imbalance mitochondrial homeostasis mitophagy oxidative stress kidney allograft kidney rejection ischemia acute kidney injury (AKI) chronic kidney disease (CKD) tricarboxylic acid (TCA) cycle mitochondrial metabolism mitochondrial redox signaling mitochondrial proteins oxidative phosphorylation (OXPHOS) fatty acid (FA) β-oxidation mitochondrial dynamics biogenesis diabetes kidney mitochondria Oryza sativa rice husk TCA cycle metabolites kidney diseases renalase chronic kidney disease major adverse cardiovascular outcomes cadmium kidney injury renal toxicity oxidative damage proximal tubule controlled oxygenated rewarming mitochondrial uncoupling rewarming injury temperature paradox redox mitochondrial dysfunction SGLT2 mitochondrial reactive oxygen species Warburg effect podocytopathies mitochondrial oxidative stress reactive oxygen species (ROS) antioxidant defense cell death n/a thema EDItEUR::M Medicine and Nursing thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology Redox Imbalance and Mitochondrial Abnormalities in Kidney Disease |
| title | Redox Imbalance and Mitochondrial Abnormalities in Kidney Disease |
| title_full | Redox Imbalance and Mitochondrial Abnormalities in Kidney Disease |
| title_fullStr | Redox Imbalance and Mitochondrial Abnormalities in Kidney Disease |
| title_full_unstemmed | Redox Imbalance and Mitochondrial Abnormalities in Kidney Disease |
| title_short | Redox Imbalance and Mitochondrial Abnormalities in Kidney Disease |
| title_sort | redox imbalance and mitochondrial abnormalities in kidney disease |
| topic | diabetic kidney disease caloric restriction NADH/NAD+ redox imbalance mitochondrial homeostasis mitophagy oxidative stress kidney allograft kidney rejection ischemia acute kidney injury (AKI) chronic kidney disease (CKD) tricarboxylic acid (TCA) cycle mitochondrial metabolism mitochondrial redox signaling mitochondrial proteins oxidative phosphorylation (OXPHOS) fatty acid (FA) β-oxidation mitochondrial dynamics biogenesis diabetes kidney mitochondria Oryza sativa rice husk TCA cycle metabolites kidney diseases renalase chronic kidney disease major adverse cardiovascular outcomes cadmium kidney injury renal toxicity oxidative damage proximal tubule controlled oxygenated rewarming mitochondrial uncoupling rewarming injury temperature paradox redox mitochondrial dysfunction SGLT2 mitochondrial reactive oxygen species Warburg effect podocytopathies mitochondrial oxidative stress reactive oxygen species (ROS) antioxidant defense cell death n/a thema EDItEUR::M Medicine and Nursing thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology |
| topic_facet | diabetic kidney disease caloric restriction NADH/NAD+ redox imbalance mitochondrial homeostasis mitophagy oxidative stress kidney allograft kidney rejection ischemia acute kidney injury (AKI) chronic kidney disease (CKD) tricarboxylic acid (TCA) cycle mitochondrial metabolism mitochondrial redox signaling mitochondrial proteins oxidative phosphorylation (OXPHOS) fatty acid (FA) β-oxidation mitochondrial dynamics biogenesis diabetes kidney mitochondria Oryza sativa rice husk TCA cycle metabolites kidney diseases renalase chronic kidney disease major adverse cardiovascular outcomes cadmium kidney injury renal toxicity oxidative damage proximal tubule controlled oxygenated rewarming mitochondrial uncoupling rewarming injury temperature paradox redox mitochondrial dysfunction SGLT2 mitochondrial reactive oxygen species Warburg effect podocytopathies mitochondrial oxidative stress reactive oxygen species (ROS) antioxidant defense cell death n/a thema EDItEUR::M Medicine and Nursing thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology |
| url | ONIX_20220506_9783036537573_85 |