Endothelial Dysfunction: From Pathophysiology to Novel Therapeutic Approaches

Dear colleagues, This Special Issue, “Endothelial Dysfunction: From Pathophysiology to Novel Therapeutic Approaches”, focuses on the pathophysiology of endothelial dysfunction, new biomarkers for endothelial dysfunction related to cardiovascular disorders or tumors, and novel therapeutic approaches...

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Format:	Online
Sprache:	Englisch
Veröffentlicht:	MDPI - Multidisciplinary Digital Publishing Institute 2022
Schlagworte:	endothelial cells oxidative stress inflammageing endothelial dysfunction aldehyde dehydrogenase-2 cardiovascular disease neurovascular disease vascular inflammation APE1/Ref-1 cardiovascular diseases subcellular localization serological biomarkers atherosclerosis aerobic exercise PCSK9 LOX-1 insulin resistance macrophage polarity serum γ-glutamyltransferase essential hypertension cardiovascular risk factors angiogenesis nargenicin A1 compound 9 VEGF VEGFR2 HIF-1α electronegative low-density lipoprotein LDL(–) L5 LDL oxidized LDL oxLDL ADMA arginine arginine paradox BH4 blood pressure COVID-19 dietary supplements endothelium eNOS uncoupling heart failure hypertension L-arginine myocardial infarction NADPH nitric oxide peripheral artery disease ApoE knockout mouse atorvastatin VCAM-1 galectin-3 neutrophil/lymphocyte ratio electronegative LDL LDL(−) lectin-like oxLDL receptor-1 dyslipidemia chronic venous insufficiency prolyl oligopeptidase (POP) inflammation endothelial disfunction lung disease endothelial to mesenchymal transition pulmonary hypertension pulmonary fibrosis metformin diabetes CV risk hyperglycemia glycated lipoproteins glycated LDL glycated HDL endothelial cell dysfunction molecular mechanisms epigenetic factors therapeutic approaches vasoactive factors EndoMT TGF-β epigenetics endothelial cell glycolysis metabolism pathological angiogenesis tumor microenvironment MRI (magnetic resonance imaging) high-fat diets plaque burden low-level laser therapy phototherapy vascular disease healing ischemia vascular calcification chronic kidney disease CKD uremic toxins hyperphosphatemia vascular smooth muscle cells VSMCs macrophages n/a thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TC Biochemical engineering::TCB Biotechnology
Online-Zugang:	ONIX_20220506_9783036530369_87
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Zusammenfassung:	Dear colleagues, This Special Issue, “Endothelial Dysfunction: From Pathophysiology to Novel Therapeutic Approaches”, focuses on the pathophysiology of endothelial dysfunction, new biomarkers for endothelial dysfunction related to cardiovascular disorders or tumors, and novel therapeutic approaches for endothelial dysfunctions. Vascular endothelium is an active tissue and plays a crucial role in the maintenance of vascular homeostasis. Chronic exposure to risk factors, such as hypertension, high cholesterolemia, or oxidative stress, induces endothelial dysfunctions and results in a loss of endothelial integrity, smooth muscle cell proliferation, and macrophage recruitment. The pathophysiology of endothelial dysfunction (ED) is complex and multi-factorial factors are involved, such as oxidative stress or chronic inflammation. The primary prevention of cardiovascular risk factors and endothelial dysfunctions, as well as the early detection of or molecular imaging techniques for endothelial dysfunction, helps to prevent the development of cardiovascular disorders. Novel therapeutic approaches or drug delivery systems for endothelial dysfunctions have had promising beneficial effects in preclinical or clinical levels by affecting the progression of atherosclerotic changes, tumor angiogenesis, and host–immune reactions near tumor environments.

Endothelial Dysfunction: From Pathophysiology to Novel Therapeutic Approaches

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