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The Role of PPARs in Disease

This reprint combines recent original manuscripts and reviews covering the multiple functions of peroxisome proliferator-activated receptors in physiology and pathophysiology. Potential applications and limitations of PPAR agonists and antagonists are discussed. All original contributions were publi...

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Format: Online
Sprog:engelsk
Udgivet: MDPI - Multidisciplinary Digital Publishing Institute 2022
Fag:
peroxisome-proliferator activated receptors
tumor angiogenesis
tumor progression
metastasis formation
endothelial cells
RNA sequencing
PPARs
toxicology
pharmacology
ligand
vascular
coronary artery
lipidomics
eicosanoids
inflammation
CYP450
peroxisome proliferator-activated receptor
angiogenesis
proliferation
metastasis
immortality
resistance to cell death
growth suppressors
immune system
cellular metabolism
PPAR
nuclear receptors
addiction
alcohol
nicotine
opioids
psychostimulants
animal models
human studies
Alzheimer’s
risk factors
PPARα
lipids
fatty acids
modulators
cognition
sex
therapy
hypertrophic adipocytes
PPARG isoforms
PPARG splicing
dominant-negative isoform
in vitro adipocytes
adipogenesis
hypertrophic obesity
insulin-resistance
peroxisome proliferator-activated receptors (PPARs)
synthetic agonists
non-alcoholic fatty liver disease (NAFLD)
non-alcoholic steatohepatitis (NASH)
fibrosis
Sirtuin1
peroxisome proliferator-activated receptor-γ coactivator-1α
peroxisome proliferator activated receptors
obesity
metabolic syndrome
vitamin B12
folate
fetal programming
inherited metabolic disorders
PGC-1α, disease
kidney
cancer
AKI
CKD
nephron
PKD
cilia
cystogenesis
ligands
Alzheimer’s disease (AD)
thema EDItEUR::M Medicine and Nursing
thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFG Physiology
Online adgang:ONIX_20220506_9783036539928_104
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Summary:This reprint combines recent original manuscripts and reviews covering the multiple functions of peroxisome proliferator-activated receptors in physiology and pathophysiology. Potential applications and limitations of PPAR agonists and antagonists are discussed. All original contributions were published in Cells.

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