Obálka

Regional Intestinal Drug Absorption

The gastrointestinal tract (GIT) can be broadly divided into several regions: the stomach, the small intestine (which is subdivided to duodenum, jejunum, and ileum), and the colon. The conditions and environment in each of these segments, and even within the segment, are dependent on many factors, e...

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Uloženo v:
Médium: Online
Jazyk:angličtina
Vydáno: MDPI - Multidisciplinary Digital Publishing Institute 2022
Témata:
bioequivalence
Biopharmaceutics Classification System
in vitro
dissolution test
pravastatin
oral absorption
in silico modeling
GastroPlus
Phoenix WinNonlin
pharmacokinetics
clinical studies
ibuprofen
manometry
gastrointestinal
mechanistic modeling
PBPK
PBBM
disintegration
dissolution
enteric-coated
ICH
quality control
regional intestinal permeability
permeation enhancers
absorption-modifying excipients
oral peptide delivery
intestinal perfusion
pharmaceutical development
controlled release drug product
biopharmaceutics classification system
drug solubility
drug permeability
location-dependent absorption
segregated flow intestinal model (SFM)
traditional model (TM)
route-dependent intestinal metabolism
first-pass effect
drug-drug interactions
DDI
in vitro in vivo extrapolations
IVIVE
zero-order absorption
first-order absorption
combined zero- and first-order absorption
transit compartment absorption model
in situ perfusion
microdevices
shape
mucoadhesion
colon absorption
nutrient digestion
nutrient absorption
gastrointestinal hormone
postprandial glycaemia
energy intake
region of the gut
obesity
type 2 diabetes
Franz–PAMPA
BCS drugs
biomimetic membrane
Franz cell
passive drug transport
BCS class IV drugs
segmental-dependent intestinal permeability
intestinal absorption
oral drug delivery
biopharmaceutics
physiologically-based pharmacokinetic (PBPK) modeling
furosemide
intestinal permeability
human colon carcinoma cell layer (Caco-2)
hierarchical support vector regression (HSVR)
drug absorption
drug solubility/dissolution
regional/segmental-dependent permeability and absorption
thema EDItEUR::M Medicine and Nursing
thema EDItEUR::K Economics, Finance, Business and Management::KN Industry and industrial studies::KND Manufacturing industries
On-line přístup:ONIX_20220506_9783036536583_117
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