New Advances in Melanoma
Melanoma is a very aggressive tumor which is derived from the transformation of pigment-producing cells termed the melanocytes. This cancer type accounts for most of the deaths associated with skin cancer as well as its incidence and is in constant evolution. Because of the rapid and very high metas...
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| Langue: | anglais |
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MDPI - Multidisciplinary Digital Publishing Institute
2022
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| Accès en ligne: | ONIX_20220506_9783036534534_160 |
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| description | Melanoma is a very aggressive tumor which is derived from the transformation of pigment-producing cells termed the melanocytes. This cancer type accounts for most of the deaths associated with skin cancer as well as its incidence and is in constant evolution. Because of the rapid and very high metastatic potential of this tumor, melanoma prognosis has been quite poor for a long time. In the past decade, groundbreaking discoveries in the melanoma research field have led to the development of two main treatment strategies: combination therapies targeting specific kinases or combination therapies focused on immune checkpoint inhibitors (ICIs). These treatment approaches have become the standard of care in most cancer centers and significantly improved the prognosis and overall survival of advanced melanoma patients. Nevertheless, many patients do not benefit from or even respond to these treatments. It is therefore essential to better comprehend the phenomenon of drug resistance, immune escape mechanisms, as well as to search for alternative treatment strategies. In addition, strong predictive biomarkers are desperately needed to improve clinical efficacy. The aim of this Special Issue is to present recent advances in the field of melanoma research, in which the abovementioned areas represent the primary focus, and other relevant themes are also discussed. |
| format | Online |
| id | doab-20.500.12854ir-81094 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2022 |
| publishDateRange | 2022 |
| publishDateSort | 2022 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-810942024-03-31T13:09:11Z New Advances in Melanoma Larribère, Lionel melanoma targeted therapies BRAF druggable mutations real-time PCR NGS assay immune escape microRNA transporter associated with antigen processing incidence population-based study epidemiology Spain skin cancer single-cell transcriptome sequencing treatment response pseudotime analysis treatment ubiquitination miRNAs embryogenesis melanoblasts melanoblast NF1 transcriptome RNAseq Trp-1 metastasis animal models lung mice thema EDItEUR::M Medicine and Nursing::MB Medicine: general issues::MBN Public health and preventive medicine Melanoma is a very aggressive tumor which is derived from the transformation of pigment-producing cells termed the melanocytes. This cancer type accounts for most of the deaths associated with skin cancer as well as its incidence and is in constant evolution. Because of the rapid and very high metastatic potential of this tumor, melanoma prognosis has been quite poor for a long time. In the past decade, groundbreaking discoveries in the melanoma research field have led to the development of two main treatment strategies: combination therapies targeting specific kinases or combination therapies focused on immune checkpoint inhibitors (ICIs). These treatment approaches have become the standard of care in most cancer centers and significantly improved the prognosis and overall survival of advanced melanoma patients. Nevertheless, many patients do not benefit from or even respond to these treatments. It is therefore essential to better comprehend the phenomenon of drug resistance, immune escape mechanisms, as well as to search for alternative treatment strategies. In addition, strong predictive biomarkers are desperately needed to improve clinical efficacy. The aim of this Special Issue is to present recent advances in the field of melanoma research, in which the abovementioned areas represent the primary focus, and other relevant themes are also discussed. 2022-05-06T11:27:22Z 2022-05-06T11:27:22Z 2022 book ONIX_20220506_9783036534534_160 9783036534534 9783036534541 https://directory.doabooks.org/handle/20.500.12854/81094 eng image/jpeg Attribution 4.0 International https://mdpi.com/books/pdfview/book/5123 https://mdpi.com/books/pdfview/book/5123 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-0365-3454-1 10.3390/books978-3-0365-3454-1 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783036534534 9783036534541 148 Basel open access |
| spellingShingle | melanoma targeted therapies BRAF druggable mutations real-time PCR NGS assay immune escape microRNA transporter associated with antigen processing incidence population-based study epidemiology Spain skin cancer single-cell transcriptome sequencing treatment response pseudotime analysis treatment ubiquitination miRNAs embryogenesis melanoblasts melanoblast NF1 transcriptome RNAseq Trp-1 metastasis animal models lung mice thema EDItEUR::M Medicine and Nursing::MB Medicine: general issues::MBN Public health and preventive medicine New Advances in Melanoma |
| title | New Advances in Melanoma |
| title_full | New Advances in Melanoma |
| title_fullStr | New Advances in Melanoma |
| title_full_unstemmed | New Advances in Melanoma |
| title_short | New Advances in Melanoma |
| title_sort | new advances in melanoma |
| topic | melanoma targeted therapies BRAF druggable mutations real-time PCR NGS assay immune escape microRNA transporter associated with antigen processing incidence population-based study epidemiology Spain skin cancer single-cell transcriptome sequencing treatment response pseudotime analysis treatment ubiquitination miRNAs embryogenesis melanoblasts melanoblast NF1 transcriptome RNAseq Trp-1 metastasis animal models lung mice thema EDItEUR::M Medicine and Nursing::MB Medicine: general issues::MBN Public health and preventive medicine |
| topic_facet | melanoma targeted therapies BRAF druggable mutations real-time PCR NGS assay immune escape microRNA transporter associated with antigen processing incidence population-based study epidemiology Spain skin cancer single-cell transcriptome sequencing treatment response pseudotime analysis treatment ubiquitination miRNAs embryogenesis melanoblasts melanoblast NF1 transcriptome RNAseq Trp-1 metastasis animal models lung mice thema EDItEUR::M Medicine and Nursing::MB Medicine: general issues::MBN Public health and preventive medicine |
| url | ONIX_20220506_9783036534534_160 |