Update on the Management of Non-Obstructive Azoospermia: Current Evidence and Unmet Needs
Azoospermia, defined as the absence of sperm in the ejaculate after examination of the centrifuged specimens, affects about 1% of the male population and 10–15% of infertile men. In about two-thirds of cases, this is caused by severe spermatogenic dysfunction, and it is commonly termed “nonobstructi...
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| Idioma: | anglès |
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MDPI - Multidisciplinary Digital Publishing Institute
2022
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| Accés en línia: | ONIX_20220506_9783036534336_202 |
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| description | Azoospermia, defined as the absence of sperm in the ejaculate after examination of the centrifuged specimens, affects about 1% of the male population and 10–15% of infertile men. In about two-thirds of cases, this is caused by severe spermatogenic dysfunction, and it is commonly termed “nonobstructive azoospermia” (NOA) to differentiate it from the less severe form of azoospermia caused by the obstruction of the seminal tract (obstructive azoospermia—OA), the latter affecting the remaining one-third of cases. Managing patients with NOA is challenging due to the severity of spermatogenic dysfunction and the lack of medical treatments, with surgical retrieval of testicular sperm being the only way of enabling some of these patients to father their own biological children. In-depth clinical knowledge is key for supporting clinical reasoning and decision making when counselling patients with NOA, and surgical skill is required to maximize the outcome of surgical procedures that aim to retrieve testicular sperm. The present book is a collection of scientific papers published in a Special Issue of the Journal of Clinical Medicine, authored by some of the most influential researchers in the field. The Special Issue, and thus also this book, were conceived to provide early career reproductive urologists and endocrinologists with an update of the scientific evidence in the field, together with surgical tips. |
| format | Online |
| id | doab-20.500.12854ir-81136 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2022 |
| publishDateRange | 2022 |
| publishDateSort | 2022 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-811362024-03-31T13:08:14Z Update on the Management of Non-Obstructive Azoospermia: Current Evidence and Unmet Needs Colpi, Giovanni M. Caroppo, Ettore nonobstructive azoospermia micro-TESE FSH treatment hormonal treatment testosterone level microdissection testicular sperm extraction non-obstructive azoospermia management infertility intracytoplasmic sperm injection testicular azoospermia sperm selection sperm cryopreservation in vitro maturation azoospermia diagnosis male infertility spermatogenic failure testis biopsy sperm retrieval genetic testing endocrine evaluation review hypogonadism Sertoli cell-only syndrome testicular spermatozoa processing microfluidics new technologies genetics exome WES Y chromosome cancer NOA genes general health ICSI offspring health microTESE prediction model n/a thema EDItEUR::M Medicine and Nursing thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology Azoospermia, defined as the absence of sperm in the ejaculate after examination of the centrifuged specimens, affects about 1% of the male population and 10–15% of infertile men. In about two-thirds of cases, this is caused by severe spermatogenic dysfunction, and it is commonly termed “nonobstructive azoospermia” (NOA) to differentiate it from the less severe form of azoospermia caused by the obstruction of the seminal tract (obstructive azoospermia—OA), the latter affecting the remaining one-third of cases. Managing patients with NOA is challenging due to the severity of spermatogenic dysfunction and the lack of medical treatments, with surgical retrieval of testicular sperm being the only way of enabling some of these patients to father their own biological children. In-depth clinical knowledge is key for supporting clinical reasoning and decision making when counselling patients with NOA, and surgical skill is required to maximize the outcome of surgical procedures that aim to retrieve testicular sperm. The present book is a collection of scientific papers published in a Special Issue of the Journal of Clinical Medicine, authored by some of the most influential researchers in the field. The Special Issue, and thus also this book, were conceived to provide early career reproductive urologists and endocrinologists with an update of the scientific evidence in the field, together with surgical tips. 2022-05-06T11:30:32Z 2022-05-06T11:30:32Z 2022 book ONIX_20220506_9783036534336_202 9783036534336 9783036534343 https://directory.doabooks.org/handle/20.500.12854/81136 eng image/jpeg Attribution 4.0 International https://mdpi.com/books/pdfview/book/5167 https://mdpi.com/books/pdfview/book/5167 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-0365-3434-3 10.3390/books978-3-0365-3434-3 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783036534336 9783036534343 168 Basel open access |
| spellingShingle | nonobstructive azoospermia micro-TESE FSH treatment hormonal treatment testosterone level microdissection testicular sperm extraction non-obstructive azoospermia management infertility intracytoplasmic sperm injection testicular azoospermia sperm selection sperm cryopreservation in vitro maturation azoospermia diagnosis male infertility spermatogenic failure testis biopsy sperm retrieval genetic testing endocrine evaluation review hypogonadism Sertoli cell-only syndrome testicular spermatozoa processing microfluidics new technologies genetics exome WES Y chromosome cancer NOA genes general health ICSI offspring health microTESE prediction model n/a thema EDItEUR::M Medicine and Nursing thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology Update on the Management of Non-Obstructive Azoospermia: Current Evidence and Unmet Needs |
| title | Update on the Management of Non-Obstructive Azoospermia: Current Evidence and Unmet Needs |
| title_full | Update on the Management of Non-Obstructive Azoospermia: Current Evidence and Unmet Needs |
| title_fullStr | Update on the Management of Non-Obstructive Azoospermia: Current Evidence and Unmet Needs |
| title_full_unstemmed | Update on the Management of Non-Obstructive Azoospermia: Current Evidence and Unmet Needs |
| title_short | Update on the Management of Non-Obstructive Azoospermia: Current Evidence and Unmet Needs |
| title_sort | update on the management of non obstructive azoospermia current evidence and unmet needs |
| topic | nonobstructive azoospermia micro-TESE FSH treatment hormonal treatment testosterone level microdissection testicular sperm extraction non-obstructive azoospermia management infertility intracytoplasmic sperm injection testicular azoospermia sperm selection sperm cryopreservation in vitro maturation azoospermia diagnosis male infertility spermatogenic failure testis biopsy sperm retrieval genetic testing endocrine evaluation review hypogonadism Sertoli cell-only syndrome testicular spermatozoa processing microfluidics new technologies genetics exome WES Y chromosome cancer NOA genes general health ICSI offspring health microTESE prediction model n/a thema EDItEUR::M Medicine and Nursing thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology |
| topic_facet | nonobstructive azoospermia micro-TESE FSH treatment hormonal treatment testosterone level microdissection testicular sperm extraction non-obstructive azoospermia management infertility intracytoplasmic sperm injection testicular azoospermia sperm selection sperm cryopreservation in vitro maturation azoospermia diagnosis male infertility spermatogenic failure testis biopsy sperm retrieval genetic testing endocrine evaluation review hypogonadism Sertoli cell-only syndrome testicular spermatozoa processing microfluidics new technologies genetics exome WES Y chromosome cancer NOA genes general health ICSI offspring health microTESE prediction model n/a thema EDItEUR::M Medicine and Nursing thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology |
| url | ONIX_20220506_9783036534336_202 |