Personalized Medicine in the Field of Inflammatory Skin Disorders
Skin inflammation is associated with a wide range of conditions which represent major health issues worldwide. Skin and mucosal surfaces represent the primary interface between the human body and the environment, susceptible to numerous factors whose action results in diseases produced by chemical s...
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| Format: | Online |
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| Idioma: | anglès |
| Publicat: |
MDPI - Multidisciplinary Digital Publishing Institute
2022
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| Matèries: | |
| Accés en línia: | ONIX_20220506_9783036535746_217 |
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| _version_ | 1869527051161042944 |
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| collection | Directory of Open Access Books |
| description | Skin inflammation is associated with a wide range of conditions which represent major health issues worldwide. Skin and mucosal surfaces represent the primary interface between the human body and the environment, susceptible to numerous factors whose action results in diseases produced by chemical substances, mechanical trauma, microbial agents, radiation, etc. Inflammation, a complex network of interactions between soluble molecules and cells, represents the main modality of the skin’s response to injuries. Numerous studies have revealed close links between chronic inflammation, oxidative stress, and carcinogenesis. Chronic inflammation induces the activation of various cell types and an increase in the production of reactive oxygen species, promoting the initiation of a malignant process. Identifying specific biomarkers is essential for understanding molecular mechanisms and developing therapies appropriate to the patient’s characteristics.Personalized medicine is an emerging field of medicine that has the potential to predict which therapy will be safe and efficacious for specific patients using an individual’s genetic profile to guide decisions regarding the diagnosis, treatment, as well as prevention of disease. This book gathers articles that present recent advancements in research involving the mechanisms that underlie the development of inflammatory skin disorders, skin and mucosal inflammation in general. |
| format | Online |
| id | doab-20.500.12854ir-81151 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2022 |
| publishDateRange | 2022 |
| publishDateSort | 2022 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-811512024-03-31T13:09:50Z Personalized Medicine in the Field of Inflammatory Skin Disorders Tampa, Mircea Neagu, Monica Caruntu, Constantin Georgescu, Simona Roxana sea-buckthorn seed oil long-chain fatty acids skin dysplastic keratinocytes UVA CD36 SR-B2 atopic dermatitis eczema JAK inhibitors systematic review meta-analysis evidence-based medicine immune-mediated skin diseases target therapy skin conditions and systemic inflammatory diseases systemic sclerosis biomarker calumenin S100A6 cytohesin 2 cannabinoids inflammation gut-lung-skin barrier signaling pathways inflammatory biomarkers psoriasis vulgaris prevalence comorbidities risk factors systemic lupus erythematous lupus nephritis lipid peroxidation DNA oxidation oxidized proteins carbohydrate oxidation antioxidative stress strategies biomarkers IgY psoriatic dermatitis imiquimod C57 BL/6 mice alginate biomaterial dressing fibers hydrogel nanofibers commercially available wound care wound healing cutaneous melanoma epigenetic regulation drug resistance therapeutic targets epigenetic therapy immune response Sutton nevi halo nevi skin tumor psoriasis proteome analysis estrogen menopause cSCC AK sialylation sialyltransferase sialidase COVID-19 pyoderma gangrenosum immunosuppression cyclosporine corticosteroids autoinflammatory disease androgenic alopecia clinical trial hair density platelet-rich plasma n/a thema EDItEUR::M Medicine and Nursing Skin inflammation is associated with a wide range of conditions which represent major health issues worldwide. Skin and mucosal surfaces represent the primary interface between the human body and the environment, susceptible to numerous factors whose action results in diseases produced by chemical substances, mechanical trauma, microbial agents, radiation, etc. Inflammation, a complex network of interactions between soluble molecules and cells, represents the main modality of the skin’s response to injuries. Numerous studies have revealed close links between chronic inflammation, oxidative stress, and carcinogenesis. Chronic inflammation induces the activation of various cell types and an increase in the production of reactive oxygen species, promoting the initiation of a malignant process. Identifying specific biomarkers is essential for understanding molecular mechanisms and developing therapies appropriate to the patient’s characteristics.Personalized medicine is an emerging field of medicine that has the potential to predict which therapy will be safe and efficacious for specific patients using an individual’s genetic profile to guide decisions regarding the diagnosis, treatment, as well as prevention of disease. This book gathers articles that present recent advancements in research involving the mechanisms that underlie the development of inflammatory skin disorders, skin and mucosal inflammation in general. 2022-05-06T11:31:34Z 2022-05-06T11:31:34Z 2022 book ONIX_20220506_9783036535746_217 9783036535746 9783036535739 https://directory.doabooks.org/handle/20.500.12854/81151 eng image/jpeg Attribution 4.0 International https://mdpi.com/books/pdfview/book/5182 https://mdpi.com/books/pdfview/book/5182 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-0365-3573-9 10.3390/books978-3-0365-3573-9 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783036535746 9783036535739 262 Basel open access |
| spellingShingle | sea-buckthorn seed oil long-chain fatty acids skin dysplastic keratinocytes UVA CD36 SR-B2 atopic dermatitis eczema JAK inhibitors systematic review meta-analysis evidence-based medicine immune-mediated skin diseases target therapy skin conditions and systemic inflammatory diseases systemic sclerosis biomarker calumenin S100A6 cytohesin 2 cannabinoids inflammation gut-lung-skin barrier signaling pathways inflammatory biomarkers psoriasis vulgaris prevalence comorbidities risk factors systemic lupus erythematous lupus nephritis lipid peroxidation DNA oxidation oxidized proteins carbohydrate oxidation antioxidative stress strategies biomarkers IgY psoriatic dermatitis imiquimod C57 BL/6 mice alginate biomaterial dressing fibers hydrogel nanofibers commercially available wound care wound healing cutaneous melanoma epigenetic regulation drug resistance therapeutic targets epigenetic therapy immune response Sutton nevi halo nevi skin tumor psoriasis proteome analysis estrogen menopause cSCC AK sialylation sialyltransferase sialidase COVID-19 pyoderma gangrenosum immunosuppression cyclosporine corticosteroids autoinflammatory disease androgenic alopecia clinical trial hair density platelet-rich plasma n/a thema EDItEUR::M Medicine and Nursing Personalized Medicine in the Field of Inflammatory Skin Disorders |
| title | Personalized Medicine in the Field of Inflammatory Skin Disorders |
| title_full | Personalized Medicine in the Field of Inflammatory Skin Disorders |
| title_fullStr | Personalized Medicine in the Field of Inflammatory Skin Disorders |
| title_full_unstemmed | Personalized Medicine in the Field of Inflammatory Skin Disorders |
| title_short | Personalized Medicine in the Field of Inflammatory Skin Disorders |
| title_sort | personalized medicine in the field of inflammatory skin disorders |
| topic | sea-buckthorn seed oil long-chain fatty acids skin dysplastic keratinocytes UVA CD36 SR-B2 atopic dermatitis eczema JAK inhibitors systematic review meta-analysis evidence-based medicine immune-mediated skin diseases target therapy skin conditions and systemic inflammatory diseases systemic sclerosis biomarker calumenin S100A6 cytohesin 2 cannabinoids inflammation gut-lung-skin barrier signaling pathways inflammatory biomarkers psoriasis vulgaris prevalence comorbidities risk factors systemic lupus erythematous lupus nephritis lipid peroxidation DNA oxidation oxidized proteins carbohydrate oxidation antioxidative stress strategies biomarkers IgY psoriatic dermatitis imiquimod C57 BL/6 mice alginate biomaterial dressing fibers hydrogel nanofibers commercially available wound care wound healing cutaneous melanoma epigenetic regulation drug resistance therapeutic targets epigenetic therapy immune response Sutton nevi halo nevi skin tumor psoriasis proteome analysis estrogen menopause cSCC AK sialylation sialyltransferase sialidase COVID-19 pyoderma gangrenosum immunosuppression cyclosporine corticosteroids autoinflammatory disease androgenic alopecia clinical trial hair density platelet-rich plasma n/a thema EDItEUR::M Medicine and Nursing |
| topic_facet | sea-buckthorn seed oil long-chain fatty acids skin dysplastic keratinocytes UVA CD36 SR-B2 atopic dermatitis eczema JAK inhibitors systematic review meta-analysis evidence-based medicine immune-mediated skin diseases target therapy skin conditions and systemic inflammatory diseases systemic sclerosis biomarker calumenin S100A6 cytohesin 2 cannabinoids inflammation gut-lung-skin barrier signaling pathways inflammatory biomarkers psoriasis vulgaris prevalence comorbidities risk factors systemic lupus erythematous lupus nephritis lipid peroxidation DNA oxidation oxidized proteins carbohydrate oxidation antioxidative stress strategies biomarkers IgY psoriatic dermatitis imiquimod C57 BL/6 mice alginate biomaterial dressing fibers hydrogel nanofibers commercially available wound care wound healing cutaneous melanoma epigenetic regulation drug resistance therapeutic targets epigenetic therapy immune response Sutton nevi halo nevi skin tumor psoriasis proteome analysis estrogen menopause cSCC AK sialylation sialyltransferase sialidase COVID-19 pyoderma gangrenosum immunosuppression cyclosporine corticosteroids autoinflammatory disease androgenic alopecia clinical trial hair density platelet-rich plasma n/a thema EDItEUR::M Medicine and Nursing |
| url | ONIX_20220506_9783036535746_217 |