Method Development and Applications for Reduced-Risk Products in Separation Science
In recent years, there has been rapid growth in the availability of innovative, non-combustible products, including oral tobacco-derived nicotine (OTDN) products, heated tobacco products (HTPs), and electronic cigarettes (also referred to as e-vapor products; EVPs). Industry, academic, and governmen...
Guardado en:
| Formato: | Online |
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| Lenguaje: | inglés |
| Publicado: |
MDPI - Multidisciplinary Digital Publishing Institute
2022
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| Materias: | |
| Acceso en línea: | ONIX_20220506_9783036536378_281 |
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| _version_ | 1869522649621725184 |
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| collection | Directory of Open Access Books |
| description | In recent years, there has been rapid growth in the availability of innovative, non-combustible products, including oral tobacco-derived nicotine (OTDN) products, heated tobacco products (HTPs), and electronic cigarettes (also referred to as e-vapor products; EVPs). Industry, academic, and government researchers are developing and validating analytical methods to extract, separate, identify, and quantitate a variety of analytes from these innovative tobacco products using a wide range of analytical techniques. These analytes include constituents such as nicotine, degradants and impurities, flavors, non-tobacco ingredients, HPHCs, and other currently unknown constituents. In this Special Issue, we received nine contributions that covered the latest analytical methods that have been developed and applied for the chemical characterization or exposure assessment to tobacco product constituents of innovative non-combustible products. This Special Issue is representative of the importance of analytical sciences research in characterizing innovative non-combustible products for guiding product design, determining relative product performance, ensuring consistency during the manufacturing process, informing toxicological risk assessment, and enabling regulatory reporting. The current advances in the development and applications of the analytical methods reported in this Special Issue can be used to inform the harm reduction potential of innovative non-combustible products for adult smokers. |
| format | Online |
| id | doab-20.500.12854ir-81215 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2022 |
| publishDateRange | 2022 |
| publishDateSort | 2022 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-812152024-03-28T03:33:01Z Method Development and Applications for Reduced-Risk Products in Separation Science Aldeek, Fadi on!® nicotine pouches nicotine dissolution release profile validation product assessment smokeless tobacco product nicotine degradants nicotine-related impurities alkaloids nicotine degradation products nicotine pouches reduced-risk products constituents method development method validation JUUL aerosol non-targeted analysis chemical characterization ENDS e-cigarette GC–MS LC–HRMS e-liquid 2,4-DNPH derivatization formaldehyde “hidden formaldehyde” formaldehyde-containing hemiacetal/acetal adducts HPHC GC-MS 3-hydroxybenzo[a]pyrene LC–MS/MS urine human biomonitoring derivatization potentially reduced-risk products propylene glycol electronic cigarette biomarker of exposure compliance marker oral tobacco derived nicotine (OTDN) pouches snus nicotine release nicotine dissolution nicotine extraction equivalence modern oral nicotine products HPHCs product characterizations n/a thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PN Chemistry thema EDItEUR::P Mathematics and Science::PN Chemistry::PNF Analytical chemistry In recent years, there has been rapid growth in the availability of innovative, non-combustible products, including oral tobacco-derived nicotine (OTDN) products, heated tobacco products (HTPs), and electronic cigarettes (also referred to as e-vapor products; EVPs). Industry, academic, and government researchers are developing and validating analytical methods to extract, separate, identify, and quantitate a variety of analytes from these innovative tobacco products using a wide range of analytical techniques. These analytes include constituents such as nicotine, degradants and impurities, flavors, non-tobacco ingredients, HPHCs, and other currently unknown constituents. In this Special Issue, we received nine contributions that covered the latest analytical methods that have been developed and applied for the chemical characterization or exposure assessment to tobacco product constituents of innovative non-combustible products. This Special Issue is representative of the importance of analytical sciences research in characterizing innovative non-combustible products for guiding product design, determining relative product performance, ensuring consistency during the manufacturing process, informing toxicological risk assessment, and enabling regulatory reporting. The current advances in the development and applications of the analytical methods reported in this Special Issue can be used to inform the harm reduction potential of innovative non-combustible products for adult smokers. 2022-05-06T11:35:51Z 2022-05-06T11:35:51Z 2022 book ONIX_20220506_9783036536378_281 9783036536378 9783036536385 https://directory.doabooks.org/handle/20.500.12854/81215 eng image/jpeg Attribution 4.0 International https://mdpi.com/books/pdfview/book/5247 https://mdpi.com/books/pdfview/book/5247 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-0365-3638-5 10.3390/books978-3-0365-3638-5 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783036536378 9783036536385 154 Basel open access |
| spellingShingle | on!® nicotine pouches nicotine dissolution release profile validation product assessment smokeless tobacco product nicotine degradants nicotine-related impurities alkaloids nicotine degradation products nicotine pouches reduced-risk products constituents method development method validation JUUL aerosol non-targeted analysis chemical characterization ENDS e-cigarette GC–MS LC–HRMS e-liquid 2,4-DNPH derivatization formaldehyde “hidden formaldehyde” formaldehyde-containing hemiacetal/acetal adducts HPHC GC-MS 3-hydroxybenzo[a]pyrene LC–MS/MS urine human biomonitoring derivatization potentially reduced-risk products propylene glycol electronic cigarette biomarker of exposure compliance marker oral tobacco derived nicotine (OTDN) pouches snus nicotine release nicotine dissolution nicotine extraction equivalence modern oral nicotine products HPHCs product characterizations n/a thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PN Chemistry thema EDItEUR::P Mathematics and Science::PN Chemistry::PNF Analytical chemistry Method Development and Applications for Reduced-Risk Products in Separation Science |
| title | Method Development and Applications for Reduced-Risk Products in Separation Science |
| title_full | Method Development and Applications for Reduced-Risk Products in Separation Science |
| title_fullStr | Method Development and Applications for Reduced-Risk Products in Separation Science |
| title_full_unstemmed | Method Development and Applications for Reduced-Risk Products in Separation Science |
| title_short | Method Development and Applications for Reduced-Risk Products in Separation Science |
| title_sort | method development and applications for reduced risk products in separation science |
| topic | on!® nicotine pouches nicotine dissolution release profile validation product assessment smokeless tobacco product nicotine degradants nicotine-related impurities alkaloids nicotine degradation products nicotine pouches reduced-risk products constituents method development method validation JUUL aerosol non-targeted analysis chemical characterization ENDS e-cigarette GC–MS LC–HRMS e-liquid 2,4-DNPH derivatization formaldehyde “hidden formaldehyde” formaldehyde-containing hemiacetal/acetal adducts HPHC GC-MS 3-hydroxybenzo[a]pyrene LC–MS/MS urine human biomonitoring derivatization potentially reduced-risk products propylene glycol electronic cigarette biomarker of exposure compliance marker oral tobacco derived nicotine (OTDN) pouches snus nicotine release nicotine dissolution nicotine extraction equivalence modern oral nicotine products HPHCs product characterizations n/a thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PN Chemistry thema EDItEUR::P Mathematics and Science::PN Chemistry::PNF Analytical chemistry |
| topic_facet | on!® nicotine pouches nicotine dissolution release profile validation product assessment smokeless tobacco product nicotine degradants nicotine-related impurities alkaloids nicotine degradation products nicotine pouches reduced-risk products constituents method development method validation JUUL aerosol non-targeted analysis chemical characterization ENDS e-cigarette GC–MS LC–HRMS e-liquid 2,4-DNPH derivatization formaldehyde “hidden formaldehyde” formaldehyde-containing hemiacetal/acetal adducts HPHC GC-MS 3-hydroxybenzo[a]pyrene LC–MS/MS urine human biomonitoring derivatization potentially reduced-risk products propylene glycol electronic cigarette biomarker of exposure compliance marker oral tobacco derived nicotine (OTDN) pouches snus nicotine release nicotine dissolution nicotine extraction equivalence modern oral nicotine products HPHCs product characterizations n/a thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PN Chemistry thema EDItEUR::P Mathematics and Science::PN Chemistry::PNF Analytical chemistry |
| url | ONIX_20220506_9783036536378_281 |