Searching for Order in Body Clocks
Physiological rhythms are central to life. Mammalian behavior and metabolism are organized around the day and night by the regulated action of cell-autonomous clocks that exist throughout our bodies. At the core of this molecular clockwork are multiple coupled feedback loops that generate sustained...
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| Định dạng: | Online |
| Ngôn ngữ: | Tiếng Anh |
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Logos Verlag
2022
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| Những chủ đề: | |
| Truy cập trực tuyến: | OCN: 1325982209 |
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| _version_ | 1869527335529611264 |
|---|---|
| author | Olmo, Marta del |
| author_browse | Olmo, Marta del |
| author_facet | Olmo, Marta del |
| author_sort | Olmo, Marta del |
| collection | Directory of Open Access Books |
| description | Physiological rhythms are central to life. Mammalian behavior and metabolism are organized around the day and night by the regulated action of cell-autonomous clocks that exist throughout our bodies. At the core of this molecular clockwork are multiple coupled feedback loops that generate sustained circadian rhythms in gene expression to ultimately orchestrate mammalian physiology. In this work we provide evidence for the role of metabolism in regulating the core clock. We present genes involved in energetic and redox pathways which we identified to be essential for the robustness of cellular timekeepers to temperature fluctuations. We developed the first computational model for circadian redox oscillations that contributes to the understanding of how cellular redox balance might adjust circadian rates in response to perturbations and convey timing information to the core molecular oscillator. Moreover, we show that our mathematical model can be coupled with prior published models of the transcriptional clockwork resulting in 1:1 entrainment. This experimental-theoretical approach exemplifies the need of a dynamic analysis at the system level to understand complex biological processes and provides insights into how basic timekeeping mechanisms are integrated into cellular physiology. Such knowledge might highlight new ways by which functional consequences of circadian timekeeping can be explored in the context of human health and disease. |
| format | Online |
| id | doab-20.500.12854ir-81610 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2022 |
| publishDateRange | 2022 |
| publishDateSort | 2022 |
| publisher | Logos Verlag |
| publisherStr | Logos Verlag |
| record_format | ojs |
| spelling | doab-20.500.12854ir-816102025-07-31T14:54:12Z Searching for Order in Body Clocks Olmo, Marta del Health & Fitness Sleep thema EDItEUR::V Health, Relationships and Personal development::VF Family and health::VFJ Coping with / advice about personal, social and health topics Physiological rhythms are central to life. Mammalian behavior and metabolism are organized around the day and night by the regulated action of cell-autonomous clocks that exist throughout our bodies. At the core of this molecular clockwork are multiple coupled feedback loops that generate sustained circadian rhythms in gene expression to ultimately orchestrate mammalian physiology. In this work we provide evidence for the role of metabolism in regulating the core clock. We present genes involved in energetic and redox pathways which we identified to be essential for the robustness of cellular timekeepers to temperature fluctuations. We developed the first computational model for circadian redox oscillations that contributes to the understanding of how cellular redox balance might adjust circadian rates in response to perturbations and convey timing information to the core molecular oscillator. Moreover, we show that our mathematical model can be coupled with prior published models of the transcriptional clockwork resulting in 1:1 entrainment. This experimental-theoretical approach exemplifies the need of a dynamic analysis at the system level to understand complex biological processes and provides insights into how basic timekeeping mechanisms are integrated into cellular physiology. Such knowledge might highlight new ways by which functional consequences of circadian timekeeping can be explored in the context of human health and disease. 2022-05-13T08:55:41Z 2022-05-13T08:55:41Z 2022-04-23T05:33:00Z 2021 book OCN: 1325982209 https://library.oapen.org/handle/20.500.12657/54146 9783832554064 https://directory.doabooks.org/handle/20.500.12854/81610 eng open access image/jpeg image/jpeg image/jpeg image/jpeg image/jpeg n/a n/a n/a n/a n/a https://library.oapen.org/bitstream/20.500.12657/54146/1/external_content.pdf https://library.oapen.org/bitstream/20.500.12657/54146/1/external_content.pdf https://library.oapen.org/bitstream/20.500.12657/54146/1/external_content.pdf https://library.oapen.org/bitstream/20.500.12657/54146/1/external_content.pdf https://library.oapen.org/bitstream/20.500.12657/54146/1/external_content.pdf Logos Verlag https://doi.org/10.30819/5406 https://doi.org/10.30819/5406 9783832554064 Knowledge Unlatched (KU) KU Open Services Logos Verlag open access |
| spellingShingle | Health & Fitness Sleep thema EDItEUR::V Health, Relationships and Personal development::VF Family and health::VFJ Coping with / advice about personal, social and health topics Olmo, Marta del Searching for Order in Body Clocks |
| title | Searching for Order in Body Clocks |
| title_full | Searching for Order in Body Clocks |
| title_fullStr | Searching for Order in Body Clocks |
| title_full_unstemmed | Searching for Order in Body Clocks |
| title_short | Searching for Order in Body Clocks |
| title_sort | searching for order in body clocks |
| topic | Health & Fitness Sleep thema EDItEUR::V Health, Relationships and Personal development::VF Family and health::VFJ Coping with / advice about personal, social and health topics |
| topic_facet | Health & Fitness Sleep thema EDItEUR::V Health, Relationships and Personal development::VF Family and health::VFJ Coping with / advice about personal, social and health topics |
| url | OCN: 1325982209 |
| work_keys_str_mv | AT olmomartadel searchingfororderinbodyclocks |