Amyotrophic Lateral Sclerosis
Amyotrophic lateral sclerosis is a fatal, progressive neurodegenerative disorder characterized by motor neuron cell death in the brain and spinal cord. The typical disease symptom is the rapid loss of muscle control, which eventually leads to the complete paralysis of voluntary muscles of the entire...
I tiakina i:
| Hōputu: | Online |
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| Reo: | Ingarihi |
| I whakaputaina: |
Exon Publications
2022
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| Ngā marau: | |
| Urunga tuihono: | https://directory.doabooks.org/handle/20.500.12854/81840 |
| Ngā Tūtohu: |
Kāore He Tūtohu, Me noho koe te mea tuatahi ki te tūtohu i tēnei pūkete!
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| _version_ | 1869519875749183488 |
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| collection | Directory of Open Access Books |
| description | Amyotrophic lateral sclerosis is a fatal, progressive neurodegenerative disorder characterized by motor neuron cell death in the brain and spinal cord. The typical disease symptom is the rapid loss of muscle control, which eventually leads to the complete paralysis of voluntary muscles of the entire body. There is no curative treatment for amyotrophic lateral sclerosis. The rarity of the disease and the difficulties in accurate early diagnosis are the major challenges in the proper understanding of the disease and the development of curative therapy. This book brings together a team of experts, both clinicians and basic scientists, to provide a comprehensive understanding of amyotrophic lateral sclerosis, challenges, and approaches to combat this devastating disease. The clinical chapters provide excellent views of diagnosis, pathology, management, and the problem of diagnostic delay. The basic science chapters provide a comprehensive description of pathomechanisms and therapies with emphasis on dysfunctional astrocytes, impaired synaptic transmission, defective axonal transport, biomarkers, cell-based therapies, and gut microbiota. The book is primarily aimed at clinicians and basic scientists; however, it will likely be of interest to a wide audience interested in amyotrophic lateral sclerosis. |
| format | Online |
| id | doab-20.500.12854ir-81840 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2022 |
| publishDateRange | 2022 |
| publishDateSort | 2022 |
| publisher | Exon Publications |
| publisherStr | Exon Publications |
| record_format | ojs |
| spelling | doab-20.500.12854ir-818402022-05-22T01:34:57Z Amyotrophic Lateral Sclerosis Araki, Toshiyuki Clinical Manifestation of Amyotrophic Lateral Sclerosis; Management of Amyotrophic Lateral Sclerosis; Diagnostic Delay in Amyotrophic Lateral Sclerosis; Astrocytes in Amyotrophic Lateral Sclerosis; Synaptic Transmission in Amyotrophic Lateral Sclerosis; Motoneuron Excitability Defects in Amyotrophic Lateral Sclerosis; Axonal Transport in Amyotrophic Lateral Sclerosis; Blood-based Biomarkers for Amyotrophic Lateral Sclerosis; Cell Therapy for Amyotrophic Lateral Sclerosis; Gut Microbiota in Amyotrophic Lateral Sclerosis MJN Amyotrophic lateral sclerosis is a fatal, progressive neurodegenerative disorder characterized by motor neuron cell death in the brain and spinal cord. The typical disease symptom is the rapid loss of muscle control, which eventually leads to the complete paralysis of voluntary muscles of the entire body. There is no curative treatment for amyotrophic lateral sclerosis. The rarity of the disease and the difficulties in accurate early diagnosis are the major challenges in the proper understanding of the disease and the development of curative therapy. This book brings together a team of experts, both clinicians and basic scientists, to provide a comprehensive understanding of amyotrophic lateral sclerosis, challenges, and approaches to combat this devastating disease. The clinical chapters provide excellent views of diagnosis, pathology, management, and the problem of diagnostic delay. The basic science chapters provide a comprehensive description of pathomechanisms and therapies with emphasis on dysfunctional astrocytes, impaired synaptic transmission, defective axonal transport, biomarkers, cell-based therapies, and gut microbiota. The book is primarily aimed at clinicians and basic scientists; however, it will likely be of interest to a wide audience interested in amyotrophic lateral sclerosis. Published 2022-05-22T01:34:55Z 2022-05-22T01:34:55Z 2021-07-25 book 9780645001778 https://directory.doabooks.org/handle/20.500.12854/81840 eng image/png Attribution-NonCommercial-NoDerivatives 4.0 International https://exonpublications.com/index.php/exon/issue/view/18 Exon Publications 10.36255/exonpublications.amyotrophiclateralsclerosis.2021 10.36255/exonpublications.amyotrophiclateralsclerosis.2021 2d6001a3-9e06-4979-bf02-6974e313eb24 9780645001778 162 Australia open access |
| spellingShingle | Clinical Manifestation of Amyotrophic Lateral Sclerosis; Management of Amyotrophic Lateral Sclerosis; Diagnostic Delay in Amyotrophic Lateral Sclerosis; Astrocytes in Amyotrophic Lateral Sclerosis; Synaptic Transmission in Amyotrophic Lateral Sclerosis; Motoneuron Excitability Defects in Amyotrophic Lateral Sclerosis; Axonal Transport in Amyotrophic Lateral Sclerosis; Blood-based Biomarkers for Amyotrophic Lateral Sclerosis; Cell Therapy for Amyotrophic Lateral Sclerosis; Gut Microbiota in Amyotrophic Lateral Sclerosis MJN Amyotrophic Lateral Sclerosis |
| title | Amyotrophic Lateral Sclerosis |
| title_full | Amyotrophic Lateral Sclerosis |
| title_fullStr | Amyotrophic Lateral Sclerosis |
| title_full_unstemmed | Amyotrophic Lateral Sclerosis |
| title_short | Amyotrophic Lateral Sclerosis |
| title_sort | amyotrophic lateral sclerosis |
| topic | Clinical Manifestation of Amyotrophic Lateral Sclerosis; Management of Amyotrophic Lateral Sclerosis; Diagnostic Delay in Amyotrophic Lateral Sclerosis; Astrocytes in Amyotrophic Lateral Sclerosis; Synaptic Transmission in Amyotrophic Lateral Sclerosis; Motoneuron Excitability Defects in Amyotrophic Lateral Sclerosis; Axonal Transport in Amyotrophic Lateral Sclerosis; Blood-based Biomarkers for Amyotrophic Lateral Sclerosis; Cell Therapy for Amyotrophic Lateral Sclerosis; Gut Microbiota in Amyotrophic Lateral Sclerosis MJN |
| topic_facet | Clinical Manifestation of Amyotrophic Lateral Sclerosis; Management of Amyotrophic Lateral Sclerosis; Diagnostic Delay in Amyotrophic Lateral Sclerosis; Astrocytes in Amyotrophic Lateral Sclerosis; Synaptic Transmission in Amyotrophic Lateral Sclerosis; Motoneuron Excitability Defects in Amyotrophic Lateral Sclerosis; Axonal Transport in Amyotrophic Lateral Sclerosis; Blood-based Biomarkers for Amyotrophic Lateral Sclerosis; Cell Therapy for Amyotrophic Lateral Sclerosis; Gut Microbiota in Amyotrophic Lateral Sclerosis MJN |
| url | https://directory.doabooks.org/handle/20.500.12854/81840 |