Sfingolipidi bioattivi e loro ruolo nell'azione biologica di fattori di crescita e citochine
This book gives an analysis of the role of the bioactive sphingolipids sphingosine-1-phosphate (S1P) and ceramide 1-phosphate (C1P) in the skeletal muscle. The enzyme that produces S1P, sphingosine kinase 1 (SK1) has proved crucial in the biological action of growth factors and cytokines involved in...
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| 格式: | Online |
| 语言: | 意大利语 |
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Firenze University Press
2022
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| 在线阅读: | ONIX_20220531_9788866552192_314 |
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| _version_ | 1869521628365324288 |
|---|---|
| author | Bernacchioni, Caterina |
| author_browse | Bernacchioni, Caterina |
| author_facet | Bernacchioni, Caterina |
| author_sort | Bernacchioni, Caterina |
| collection | Directory of Open Access Books |
| description | This book gives an analysis of the role of the bioactive sphingolipids sphingosine-1-phosphate (S1P) and ceramide 1-phosphate (C1P) in the skeletal muscle. The enzyme that produces S1P, sphingosine kinase 1 (SK1) has proved crucial in the biological action of growth factors and cytokines involved in the inflammatory process that follows muscular damage. Indeed, in myoblasts the cytokine TGFβ exercises its fibrotic action through induction of the SK1/S1P axis. Furthermore, the PDGF growth factor, positive regulator of proliferation and motility, activates the enzyme SK1 and the transactivation of S1P1 inhibits the proliferation and induces the migration induced by the growth factor. Finally, the mitogenic role of C1P in myoblasts has been identified, characterizing the signalling pathways involved. |
| format | Online |
| id | doab-20.500.12854ir-81970 |
| institution | Directory of Open Access Books |
| language | ita |
| publishDate | 2022 |
| publishDateRange | 2022 |
| publishDateSort | 2022 |
| publisher | Firenze University Press |
| publisherStr | Firenze University Press |
| record_format | ojs |
| spelling | doab-20.500.12854ir-819702025-03-15T05:06:25Z Sfingolipidi bioattivi e loro ruolo nell'azione biologica di fattori di crescita e citochine Bernacchioni, Caterina This book gives an analysis of the role of the bioactive sphingolipids sphingosine-1-phosphate (S1P) and ceramide 1-phosphate (C1P) in the skeletal muscle. The enzyme that produces S1P, sphingosine kinase 1 (SK1) has proved crucial in the biological action of growth factors and cytokines involved in the inflammatory process that follows muscular damage. Indeed, in myoblasts the cytokine TGFβ exercises its fibrotic action through induction of the SK1/S1P axis. Furthermore, the PDGF growth factor, positive regulator of proliferation and motility, activates the enzyme SK1 and the transactivation of S1P1 inhibits the proliferation and induces the migration induced by the growth factor. Finally, the mitogenic role of C1P in myoblasts has been identified, characterizing the signalling pathways involved. 2022-06-02T04:00:46Z 2022-06-02T04:00:46Z 2022-05-31T10:19:41Z 2012 book ONIX_20220531_9788866552192_314 OCN: 1229433487 2612-8020 https://library.oapen.org/handle/20.500.12657/55030 9788866552192 9788866552185 9788892735644 https://directory.doabooks.org/handle/20.500.12854/81970 ita Premio Tesi di Dottorato open access image/jpeg image/jpeg image/jpeg n/a n/a n/a https://library.oapen.org/bitstream/20.500.12657/55030/1/9788866552192.pdf https://library.oapen.org/bitstream/20.500.12657/55030/1/9788866552192.pdf https://library.oapen.org/bitstream/20.500.12657/55030/1/9788866552192.pdf Firenze University Press 10.36253/978-88-6655-219-2 10.36253/978-88-6655-219-2 2ec4474d-93b1-4cfa-b313-9c6019b51b1a 9788866552192 9788866552185 9788892735644 152 Firenze open access |
| spellingShingle | Bernacchioni, Caterina Sfingolipidi bioattivi e loro ruolo nell'azione biologica di fattori di crescita e citochine |
| title | Sfingolipidi bioattivi e loro ruolo nell'azione biologica di fattori di crescita e citochine |
| title_full | Sfingolipidi bioattivi e loro ruolo nell'azione biologica di fattori di crescita e citochine |
| title_fullStr | Sfingolipidi bioattivi e loro ruolo nell'azione biologica di fattori di crescita e citochine |
| title_full_unstemmed | Sfingolipidi bioattivi e loro ruolo nell'azione biologica di fattori di crescita e citochine |
| title_short | Sfingolipidi bioattivi e loro ruolo nell'azione biologica di fattori di crescita e citochine |
| title_sort | sfingolipidi bioattivi e loro ruolo nell azione biologica di fattori di crescita e citochine |
| url | ONIX_20220531_9788866552192_314 |
| work_keys_str_mv | AT bernacchionicaterina sfingolipidibioattivielororuolonellazionebiologicadifattoridicrescitaecitochine |