Proteins as possible targets for antitumor metal complexes: biophysical studies of their interactions
There is considerable interest today for the reactions of anticancer metallodrugs with proteins as these interactions might feature processes that are crucial for the biodistribution, the toxicity and even the mechanism of action of this important group of anticancer agents. Valuable structural and...
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| 格式: | Online |
| 語言: | 英语 |
| 出版: |
Firenze University Press
2022
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| 主題: | |
| 在線閱讀: | ONIX_20220531_9788884539403_152 |
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| _version_ | 1869518578259066880 |
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| author | Gabbiani, Chiara |
| author_browse | Gabbiani, Chiara |
| author_facet | Gabbiani, Chiara |
| author_sort | Gabbiani, Chiara |
| collection | Directory of Open Access Books |
| description | There is considerable interest today for the reactions of anticancer metallodrugs with proteins as these interactions might feature processes that are crucial for the biodistribution, the toxicity and even the mechanism of action of this important group of anticancer agents. Valuable structural and functional information on these adducts could be derived from several biophysical studies mainly relying on the application of X-ray diffraction and ESI MS techniques. The structural and functional information achieved on the respective metallodrug–protein adducts allowed us to identify some general trends in the reactivity of anticancer metallodrugs with protein targets. |
| format | Online |
| id | doab-20.500.12854ir-82109 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2022 |
| publishDateRange | 2022 |
| publishDateSort | 2022 |
| publisher | Firenze University Press |
| publisherStr | Firenze University Press |
| record_format | ojs |
| spelling | doab-20.500.12854ir-821092025-03-15T07:10:10Z Proteins as possible targets for antitumor metal complexes: biophysical studies of their interactions Gabbiani, Chiara Biologia Chimica There is considerable interest today for the reactions of anticancer metallodrugs with proteins as these interactions might feature processes that are crucial for the biodistribution, the toxicity and even the mechanism of action of this important group of anticancer agents. Valuable structural and functional information on these adducts could be derived from several biophysical studies mainly relying on the application of X-ray diffraction and ESI MS techniques. The structural and functional information achieved on the respective metallodrug–protein adducts allowed us to identify some general trends in the reactivity of anticancer metallodrugs with protein targets. 2022-06-02T04:04:03Z 2022-06-02T04:04:03Z 2022-05-31T10:15:26Z 2009 book ONIX_20220531_9788884539403_152 OCN: 1229752995 2612-8020 https://library.oapen.org/handle/20.500.12657/54868 9788884539403 9788884539397 9788892737679 https://directory.doabooks.org/handle/20.500.12854/82109 eng Premio Tesi di Dottorato open access image/jpeg image/jpeg image/jpeg n/a n/a n/a https://library.oapen.org/bitstream/20.500.12657/54868/1/9788884539403.pdf https://library.oapen.org/bitstream/20.500.12657/54868/1/9788884539403.pdf https://library.oapen.org/bitstream/20.500.12657/54868/1/9788884539403.pdf Firenze University Press 10.36253/978-88-8453-940-3 10.36253/978-88-8453-940-3 2ec4474d-93b1-4cfa-b313-9c6019b51b1a 9788884539403 9788884539397 9788892737679 74 Firenze open access |
| spellingShingle | Biologia Chimica Gabbiani, Chiara Proteins as possible targets for antitumor metal complexes: biophysical studies of their interactions |
| title | Proteins as possible targets for antitumor metal complexes: biophysical studies of their interactions |
| title_full | Proteins as possible targets for antitumor metal complexes: biophysical studies of their interactions |
| title_fullStr | Proteins as possible targets for antitumor metal complexes: biophysical studies of their interactions |
| title_full_unstemmed | Proteins as possible targets for antitumor metal complexes: biophysical studies of their interactions |
| title_short | Proteins as possible targets for antitumor metal complexes: biophysical studies of their interactions |
| title_sort | proteins as possible targets for antitumor metal complexes biophysical studies of their interactions |
| topic | Biologia Chimica |
| topic_facet | Biologia Chimica |
| url | ONIX_20220531_9788884539403_152 |
| work_keys_str_mv | AT gabbianichiara proteinsaspossibletargetsforantitumormetalcomplexesbiophysicalstudiesoftheirinteractions |