Purines as Transmitter Molecules: Electrophysiological Studies on Purinergic Signalling in Different Cell Systems
Purinergic nucleotides and nucleosides (ATP, ADP, AMP and adenosine) are essential intracellular metabolites involved in a number of cellular processes, from energy supply to protein phosphorylation. However, in the last years, several studies demonstrated their involvement in cell signalling by the...
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| Formato: | Online |
| Idioma: | inglês |
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Firenze University Press
2022
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| Acesso em linha: | ONIX_20220531_9788884539052_113 |
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| _version_ | 1869529127874199552 |
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| author | COPPI, Elisabetta |
| author_browse | COPPI, Elisabetta |
| author_facet | COPPI, Elisabetta |
| author_sort | COPPI, Elisabetta |
| collection | Directory of Open Access Books |
| description | Purinergic nucleotides and nucleosides (ATP, ADP, AMP and adenosine) are essential intracellular metabolites involved in a number of cellular processes, from energy supply to protein phosphorylation. However, in the last years, several studies demonstrated their involvement in cell signalling by the activation of specific membrane receptors (P1 and P2) and their role as neurotransmitters began to be investigated. The present work was aimed to clarify the effects of purinergic neurotransmission in different cell systems by using electrophysiological techniques. Relevant results of this research include the observation that P1 and P2 receptors play a deleterious role during "in vitro" ischemia in the rat brain, and the first demonstration of P2 receptor expression and function in a line of adult human mesenchymal stem cells. |
| format | Online |
| id | doab-20.500.12854ir-82784 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2022 |
| publishDateRange | 2022 |
| publishDateSort | 2022 |
| publisher | Firenze University Press |
| publisherStr | Firenze University Press |
| record_format | ojs |
| spelling | doab-20.500.12854ir-827842025-03-15T17:42:41Z Purines as Transmitter Molecules: Electrophysiological Studies on Purinergic Signalling in Different Cell Systems COPPI, Elisabetta Chimica Chimica inorganica Fisiologia Metabolismo Acidi nucleici Open Access Purinergic nucleotides and nucleosides (ATP, ADP, AMP and adenosine) are essential intracellular metabolites involved in a number of cellular processes, from energy supply to protein phosphorylation. However, in the last years, several studies demonstrated their involvement in cell signalling by the activation of specific membrane receptors (P1 and P2) and their role as neurotransmitters began to be investigated. The present work was aimed to clarify the effects of purinergic neurotransmission in different cell systems by using electrophysiological techniques. Relevant results of this research include the observation that P1 and P2 receptors play a deleterious role during "in vitro" ischemia in the rat brain, and the first demonstration of P2 receptor expression and function in a line of adult human mesenchymal stem cells. 2022-06-02T04:17:23Z 2022-06-02T04:17:23Z 2022-05-31T10:14:26Z 2008 book ONIX_20220531_9788884539052_113 OCN: 971086593 2612-8020 https://library.oapen.org/handle/20.500.12657/54829 9788884539052 9788884539045 9788892737891 https://directory.doabooks.org/handle/20.500.12854/82784 eng Premio Tesi di Dottorato open access image/jpeg image/jpeg image/jpeg n/a n/a n/a https://library.oapen.org/bitstream/20.500.12657/54829/1/9788884539052.pdf https://library.oapen.org/bitstream/20.500.12657/54829/1/9788884539052.pdf https://library.oapen.org/bitstream/20.500.12657/54829/1/9788884539052.pdf Firenze University Press 10.36253/978-88-8453-905-2 10.36253/978-88-8453-905-2 2ec4474d-93b1-4cfa-b313-9c6019b51b1a 9788884539052 9788884539045 9788892737891 192 Firenze open access |
| spellingShingle | Chimica Chimica inorganica Fisiologia Metabolismo Acidi nucleici Open Access COPPI, Elisabetta Purines as Transmitter Molecules: Electrophysiological Studies on Purinergic Signalling in Different Cell Systems |
| title | Purines as Transmitter Molecules: Electrophysiological Studies on Purinergic Signalling in Different Cell Systems |
| title_full | Purines as Transmitter Molecules: Electrophysiological Studies on Purinergic Signalling in Different Cell Systems |
| title_fullStr | Purines as Transmitter Molecules: Electrophysiological Studies on Purinergic Signalling in Different Cell Systems |
| title_full_unstemmed | Purines as Transmitter Molecules: Electrophysiological Studies on Purinergic Signalling in Different Cell Systems |
| title_short | Purines as Transmitter Molecules: Electrophysiological Studies on Purinergic Signalling in Different Cell Systems |
| title_sort | purines as transmitter molecules electrophysiological studies on purinergic signalling in different cell systems |
| topic | Chimica Chimica inorganica Fisiologia Metabolismo Acidi nucleici Open Access |
| topic_facet | Chimica Chimica inorganica Fisiologia Metabolismo Acidi nucleici Open Access |
| url | ONIX_20220531_9788884539052_113 |
| work_keys_str_mv | AT coppielisabetta purinesastransmittermoleculeselectrophysiologicalstudiesonpurinergicsignallingindifferentcellsystems |