Folding and aggregation studies in the acylphosphatase-like family
Folding and misfolding of proteins are considered two sides of the same coin. The delicate equilibrium existing between these two processes is crucial for any living organism and its alterations can lead to the onset of several tremendous diseases, such as Alzheimer's and Parkinson's disease. The at...
Đã lưu trong:
| Tác giả chính: | |
|---|---|
| Định dạng: | Online |
| Ngôn ngữ: | Tiếng Anh |
| Được phát hành: |
Firenze University Press
2022
|
| Những chủ đề: | |
| Truy cập trực tuyến: | ONIX_20220531_9788884539465_149 |
| Các nhãn: |
Không có thẻ, Là người đầu tiên thẻ bản ghi này!
|
| _version_ | 1869516382769512448 |
|---|---|
| author | Bemporad, Francesco |
| author_browse | Bemporad, Francesco |
| author_facet | Bemporad, Francesco |
| author_sort | Bemporad, Francesco |
| collection | Directory of Open Access Books |
| description | Folding and misfolding of proteins are considered two sides of the same coin. The delicate equilibrium existing between these two processes is crucial for any living organism and its alterations can lead to the onset of several tremendous diseases, such as Alzheimer's and Parkinson's disease. The attainment of a profound knowledge of folding/misfolding processes is a key step to understand how life works and for discovering new therapies to these diseases. In this work the author shows that proteins can display enzymatic activity even in the absence of a compact three-dimensional structure, with important implications for the study of protein enzymes. Furthermore, the author investigates the formation of protein aggregates similar to those observed in patients of amyloid-related diseases. |
| format | Online |
| id | doab-20.500.12854ir-83524 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2022 |
| publishDateRange | 2022 |
| publishDateSort | 2022 |
| publisher | Firenze University Press |
| publisherStr | Firenze University Press |
| record_format | ojs |
| spelling | doab-20.500.12854ir-835242025-03-22T21:43:46Z Folding and aggregation studies in the acylphosphatase-like family Bemporad, Francesco Medicina Biologia Chimica Folding and misfolding of proteins are considered two sides of the same coin. The delicate equilibrium existing between these two processes is crucial for any living organism and its alterations can lead to the onset of several tremendous diseases, such as Alzheimer's and Parkinson's disease. The attainment of a profound knowledge of folding/misfolding processes is a key step to understand how life works and for discovering new therapies to these diseases. In this work the author shows that proteins can display enzymatic activity even in the absence of a compact three-dimensional structure, with important implications for the study of protein enzymes. Furthermore, the author investigates the formation of protein aggregates similar to those observed in patients of amyloid-related diseases. 2022-06-02T04:32:58Z 2022-06-02T04:32:58Z 2022-05-31T10:15:21Z 2009 book ONIX_20220531_9788884539465_149 OCN: 1229759119 2612-8020 https://library.oapen.org/handle/20.500.12657/54865 9788884539465 9788884539458 9788892737686 https://directory.doabooks.org/handle/20.500.12854/83524 eng Premio Tesi di Dottorato open access image/jpeg image/jpeg image/jpeg n/a n/a n/a https://library.oapen.org/bitstream/20.500.12657/54865/1/9788884539465.pdf https://library.oapen.org/bitstream/20.500.12657/54865/1/9788884539465.pdf https://library.oapen.org/bitstream/20.500.12657/54865/1/9788884539465.pdf Firenze University Press 10.36253/978-88-8453-946-5 10.36253/978-88-8453-946-5 2ec4474d-93b1-4cfa-b313-9c6019b51b1a 9788884539465 9788884539458 9788892737686 126 Firenze open access |
| spellingShingle | Medicina Biologia Chimica Bemporad, Francesco Folding and aggregation studies in the acylphosphatase-like family |
| title | Folding and aggregation studies in the acylphosphatase-like family |
| title_full | Folding and aggregation studies in the acylphosphatase-like family |
| title_fullStr | Folding and aggregation studies in the acylphosphatase-like family |
| title_full_unstemmed | Folding and aggregation studies in the acylphosphatase-like family |
| title_short | Folding and aggregation studies in the acylphosphatase-like family |
| title_sort | folding and aggregation studies in the acylphosphatase like family |
| topic | Medicina Biologia Chimica |
| topic_facet | Medicina Biologia Chimica |
| url | ONIX_20220531_9788884539465_149 |
| work_keys_str_mv | AT bemporadfrancesco foldingandaggregationstudiesintheacylphosphataselikefamily |