A study on cholinergic signal transduction pathways involved in short term and long term memory formation in the rat hippocampus
Neurodegenerative processes alter neuronal and glial physiology and cause cognitive and mnemonic impairments. Aim of this PhD thesis is to investigate the involvement of the cholinergic system and the role of mTOR pathway in the mechanisms of memory encoding in the hippocampus and to study the patho...
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| Formaat: | Online |
| Taal: | Engels |
| Gepubliceerd in: |
Firenze University Press
2022
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| Online toegang: | ONIX_20220531_9788866559412_496 |
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| _version_ | 1869519767643095040 |
|---|---|
| author | Lana, Daniele |
| author_browse | Lana, Daniele |
| author_facet | Lana, Daniele |
| author_sort | Lana, Daniele |
| collection | Directory of Open Access Books |
| description | Neurodegenerative processes alter neuronal and glial physiology and cause cognitive and mnemonic impairments. Aim of this PhD thesis is to investigate the involvement of the cholinergic system and the role of mTOR pathway in the mechanisms of memory encoding in the hippocampus and to study the pathophysiological processes at the base of the cognitive impairments in different experimental models of neurodegeneration: in particular normal brain aging, neuroinfiammation and chronic cerebral hypoperfusion. These mechanisms are studied focusing on the morpho-functional alterations in the neuron-astrocytemicroglia triad. |
| format | Online |
| id | doab-20.500.12854ir-83854 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2022 |
| publishDateRange | 2022 |
| publishDateSort | 2022 |
| publisher | Firenze University Press |
| publisherStr | Firenze University Press |
| record_format | ojs |
| spelling | doab-20.500.12854ir-838542025-03-24T20:52:36Z A study on cholinergic signal transduction pathways involved in short term and long term memory formation in the rat hippocampus Lana, Daniele Neurodegenerative processes alter neuronal and glial physiology and cause cognitive and mnemonic impairments. Aim of this PhD thesis is to investigate the involvement of the cholinergic system and the role of mTOR pathway in the mechanisms of memory encoding in the hippocampus and to study the pathophysiological processes at the base of the cognitive impairments in different experimental models of neurodegeneration: in particular normal brain aging, neuroinfiammation and chronic cerebral hypoperfusion. These mechanisms are studied focusing on the morpho-functional alterations in the neuron-astrocytemicroglia triad. 2022-06-02T04:40:40Z 2022-06-02T04:40:40Z 2022-05-31T10:23:35Z 2015 book ONIX_20220531_9788866559412_496 OCN: 1268380643 2612-8020 https://library.oapen.org/handle/20.500.12657/55212 9788866559412 9788866559405 9788892733114 https://directory.doabooks.org/handle/20.500.12854/83854 eng Premio Tesi di Dottorato open access image/jpeg image/jpeg image/jpeg Attribution 4.0 International Attribution 4.0 International Attribution 4.0 International https://library.oapen.org/bitstream/20.500.12657/55212/1/9788866559412.pdf https://library.oapen.org/bitstream/20.500.12657/55212/1/9788866559412.pdf https://library.oapen.org/bitstream/20.500.12657/55212/1/9788866559412.pdf Firenze University Press 10.36253/978-88-6655-941-2 10.36253/978-88-6655-941-2 2ec4474d-93b1-4cfa-b313-9c6019b51b1a 9788866559412 9788866559405 9788892733114 136 Florence open access |
| spellingShingle | Lana, Daniele A study on cholinergic signal transduction pathways involved in short term and long term memory formation in the rat hippocampus |
| title | A study on cholinergic signal transduction pathways involved in short term and long term memory formation in the rat hippocampus |
| title_full | A study on cholinergic signal transduction pathways involved in short term and long term memory formation in the rat hippocampus |
| title_fullStr | A study on cholinergic signal transduction pathways involved in short term and long term memory formation in the rat hippocampus |
| title_full_unstemmed | A study on cholinergic signal transduction pathways involved in short term and long term memory formation in the rat hippocampus |
| title_short | A study on cholinergic signal transduction pathways involved in short term and long term memory formation in the rat hippocampus |
| title_sort | study on cholinergic signal transduction pathways involved in short term and long term memory formation in the rat hippocampus |
| url | ONIX_20220531_9788866559412_496 |
| work_keys_str_mv | AT lanadaniele astudyoncholinergicsignaltransductionpathwaysinvolvedinshorttermandlongtermmemoryformationintherathippocampus AT lanadaniele studyoncholinergicsignaltransductionpathwaysinvolvedinshorttermandlongtermmemoryformationintherathippocampus |