Chapter Developing a Model to Simulate the Effect of Hypothermia on Cerebral Blood Flow and Metabolism
Hypoxic ischemic encephalopathy (HIE) is a significant cause of death and neurological disability in newborns. Therapeutic hypothermia at 33.5 °C is one of the most common treatments in HIE and generally improves outcome; however 45–55% of injuries still result in death or severe neurodevelopmental...
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| Médium: | Online |
| Jazyk: | angličtina |
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Springer Nature
2022
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| On-line přístup: | https://library.oapen.org/handle/20.500.12657/56698 |
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| _version_ | 1869516102165331968 |
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| author | Russell-Buckland, Joshua Tachtsidis, Ilias |
| author_browse | Russell-Buckland, Joshua Tachtsidis, Ilias |
| author_facet | Russell-Buckland, Joshua Tachtsidis, Ilias |
| author_sort | Russell-Buckland, Joshua |
| collection | Directory of Open Access Books |
| description | Hypoxic ischemic encephalopathy (HIE) is a significant cause of death and neurological disability in newborns. Therapeutic hypothermia at 33.5 °C is one of the most common treatments in HIE and generally improves outcome; however 45–55% of injuries still result in death or severe neurodevelopmental disability. We have developed a systems biology model of cerebral oxygen transport and metabolism to model the impact of hypothermia on the piglet brain (the neonatal preclinical animal model) tissue physiology. This computational model is an extension of the BrainSignals model of the adult brain. The model predicts that during hypothermia there is a 5.1% decrease in cerebral metabolism, 1.1% decrease in blood flow and 2.3% increase in cerebral tissue oxygenation saturation. The model can be used to simulate effects of hypothermia on the brain and to help interpret bedside recordings. |
| format | Online |
| id | doab-20.500.12854ir-84053 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2022 |
| publishDateRange | 2022 |
| publishDateSort | 2022 |
| publisher | Springer Nature |
| publisherStr | Springer Nature |
| record_format | ojs |
| spelling | doab-20.500.12854ir-840532025-01-20T15:36:15Z Chapter Developing a Model to Simulate the Effect of Hypothermia on Cerebral Blood Flow and Metabolism Russell-Buckland, Joshua Tachtsidis, Ilias Broadband NIRS, Hypothermia, Systems biology Hypoxic ischemic encephalopathy (HIE) is a significant cause of death and neurological disability in newborns. Therapeutic hypothermia at 33.5 °C is one of the most common treatments in HIE and generally improves outcome; however 45–55% of injuries still result in death or severe neurodevelopmental disability. We have developed a systems biology model of cerebral oxygen transport and metabolism to model the impact of hypothermia on the piglet brain (the neonatal preclinical animal model) tissue physiology. This computational model is an extension of the BrainSignals model of the adult brain. The model predicts that during hypothermia there is a 5.1% decrease in cerebral metabolism, 1.1% decrease in blood flow and 2.3% increase in cerebral tissue oxygenation saturation. The model can be used to simulate effects of hypothermia on the brain and to help interpret bedside recordings. 2022-06-10T04:21:47Z 2022-06-10T04:21:47Z 2022-06-09T12:33:31Z 2020 chapter https://library.oapen.org/handle/20.500.12657/56698 9783030344597 https://directory.doabooks.org/handle/20.500.12854/84053 eng open access image/jpeg image/jpeg Attribution 4.0 International Attribution 4.0 International https://library.oapen.org/bitstream/20.500.12657/56698/1/Bookshelf_NBK572926.pdf https://library.oapen.org/bitstream/20.500.12657/56698/1/Bookshelf_NBK572926.pdf Springer Nature 10.1007/978-3-030-34461-0_38 10.1007/978-3-030-34461-0_38 9fa3421d-f917-4153-b9ab-fc337c396b5a Oxygen Transport to Tissue XLI Wellcome Trust d859fbd3-d884-4090-a0ec-baf821c9abfd 9783030344597 Wellcome 8 104580/Z/14/Z open access |
| spellingShingle | Broadband NIRS, Hypothermia, Systems biology Russell-Buckland, Joshua Tachtsidis, Ilias Chapter Developing a Model to Simulate the Effect of Hypothermia on Cerebral Blood Flow and Metabolism |
| title | Chapter Developing a Model to Simulate the Effect of Hypothermia on Cerebral Blood Flow and Metabolism |
| title_full | Chapter Developing a Model to Simulate the Effect of Hypothermia on Cerebral Blood Flow and Metabolism |
| title_fullStr | Chapter Developing a Model to Simulate the Effect of Hypothermia on Cerebral Blood Flow and Metabolism |
| title_full_unstemmed | Chapter Developing a Model to Simulate the Effect of Hypothermia on Cerebral Blood Flow and Metabolism |
| title_short | Chapter Developing a Model to Simulate the Effect of Hypothermia on Cerebral Blood Flow and Metabolism |
| title_sort | chapter developing a model to simulate the effect of hypothermia on cerebral blood flow and metabolism |
| topic | Broadband NIRS, Hypothermia, Systems biology |
| topic_facet | Broadband NIRS, Hypothermia, Systems biology |
| url | https://library.oapen.org/handle/20.500.12657/56698 |
| work_keys_str_mv | AT russellbucklandjoshua chapterdevelopingamodeltosimulatetheeffectofhypothermiaoncerebralbloodflowandmetabolism AT tachtsidisilias chapterdevelopingamodeltosimulatetheeffectofhypothermiaoncerebralbloodflowandmetabolism |