Chapter Broadband NIRS Cerebral Evaluation of the Hemodynamic and Oxidative State of Cytochrome-c-Oxidase Responses to +Gz Acceleration in Healthy Volunteers
We used a miniature broadband NIRS system to monitor concentration changes in brain oxygenation (oxy- and deoxy- haemoglobin [HbO2], [HHb]) and oxidised cytochrome-c-oxidase ([oxCCO]) during a high +Gz acceleration, induced by a human centrifuge, on two healthy experienced volunteers (2 male, 34 and...
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| বিন্যাস: | Online |
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Springer Nature
2022
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| অনলাইন ব্যবহার করুন: | https://library.oapen.org/handle/20.500.12657/56699 |
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| _version_ | 1869525929562210304 |
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| author | Lange, F. Bale, G. Kaynezhad, P. Pollock, R.D. Stevenson, A. Tachtsidis, I. |
| author_browse | Bale, G. Kaynezhad, P. Lange, F. Pollock, R.D. Stevenson, A. Tachtsidis, I. |
| author_facet | Lange, F. Bale, G. Kaynezhad, P. Pollock, R.D. Stevenson, A. Tachtsidis, I. |
| author_sort | Lange, F. |
| collection | Directory of Open Access Books |
| description | We used a miniature broadband NIRS system to monitor concentration changes in brain oxygenation (oxy- and deoxy- haemoglobin [HbO2], [HHb]) and oxidised cytochrome-c-oxidase ([oxCCO]) during a high +Gz acceleration, induced by a human centrifuge, on two healthy experienced volunteers (2 male, 34 and 37 years). We performed a sequence of several +Gz exposures that were terminated at the onset of visual symptoms (loss of peripheral vision). Systemic parameters were recorded (i.e. heart rate, blood pressure and arterial saturation), and brain tissue blood volume changes ([HbT] = [HbO2] + [HHb]) and oxygen delivery ([HbDiff] = [HbO2] - [HHb]) were calculated. Volunteer 1 demonstrated a decrease in [HbT] of −3.49 ± 0.02 μMol and [HbDiff] of −3.23 ± 0.44 μMol, and an increase of [oxCCO] of 0.42 ± 0.01μMol. Volunteer 2 demonstrated a decrease in [HbDiff] of −4.37 ± 0.23 μMol, and no significant change in [HbT] (0.53 ± 0.06 μMol) and [oxCCO] (0.09 ± 0.06 μMol). The variability of the brain metabolic response was related to the level of ischaemia, suggesting that suppression of metabolism was due to lack of glucose substrate delivery rather than oxygen availability. |
| format | Online |
| id | doab-20.500.12854ir-84055 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2022 |
| publishDateRange | 2022 |
| publishDateSort | 2022 |
| publisher | Springer Nature |
| publisherStr | Springer Nature |
| record_format | ojs |
| spelling | doab-20.500.12854ir-840552025-01-23T18:00:36Z Chapter Broadband NIRS Cerebral Evaluation of the Hemodynamic and Oxidative State of Cytochrome-c-Oxidase Responses to +Gz Acceleration in Healthy Volunteers Lange, F. Bale, G. Kaynezhad, P. Pollock, R.D. Stevenson, A. Tachtsidis, I. NIRS, Broadband, Cytochrome-c-oxidase, Ischaemia, Human centrifuge We used a miniature broadband NIRS system to monitor concentration changes in brain oxygenation (oxy- and deoxy- haemoglobin [HbO2], [HHb]) and oxidised cytochrome-c-oxidase ([oxCCO]) during a high +Gz acceleration, induced by a human centrifuge, on two healthy experienced volunteers (2 male, 34 and 37 years). We performed a sequence of several +Gz exposures that were terminated at the onset of visual symptoms (loss of peripheral vision). Systemic parameters were recorded (i.e. heart rate, blood pressure and arterial saturation), and brain tissue blood volume changes ([HbT] = [HbO2] + [HHb]) and oxygen delivery ([HbDiff] = [HbO2] - [HHb]) were calculated. Volunteer 1 demonstrated a decrease in [HbT] of −3.49 ± 0.02 μMol and [HbDiff] of −3.23 ± 0.44 μMol, and an increase of [oxCCO] of 0.42 ± 0.01μMol. Volunteer 2 demonstrated a decrease in [HbDiff] of −4.37 ± 0.23 μMol, and no significant change in [HbT] (0.53 ± 0.06 μMol) and [oxCCO] (0.09 ± 0.06 μMol). The variability of the brain metabolic response was related to the level of ischaemia, suggesting that suppression of metabolism was due to lack of glucose substrate delivery rather than oxygen availability. 2022-06-10T04:29:12Z 2022-06-10T04:29:12Z 2022-06-09T12:45:15Z 2020 chapter https://library.oapen.org/handle/20.500.12657/56699 9783030344597 https://directory.doabooks.org/handle/20.500.12854/84055 eng open access image/jpeg image/jpeg Attribution 4.0 International Attribution 4.0 International https://library.oapen.org/bitstream/20.500.12657/56699/1/Broadband_NIRS_Cerebral_Evaluation_of_the_Hemodyna.pdf https://library.oapen.org/bitstream/20.500.12657/56699/1/Broadband_NIRS_Cerebral_Evaluation_of_the_Hemodyna.pdf Springer Nature 10.1007/978-3-030-34461-0_43 10.1007/978-3-030-34461-0_43 9fa3421d-f917-4153-b9ab-fc337c396b5a Oxygen Transport to Tissue XLI Wellcome Trust d859fbd3-d884-4090-a0ec-baf821c9abfd 9783030344597 Wellcome 7 104580/Z/14/Z open access |
| spellingShingle | NIRS, Broadband, Cytochrome-c-oxidase, Ischaemia, Human centrifuge Lange, F. Bale, G. Kaynezhad, P. Pollock, R.D. Stevenson, A. Tachtsidis, I. Chapter Broadband NIRS Cerebral Evaluation of the Hemodynamic and Oxidative State of Cytochrome-c-Oxidase Responses to +Gz Acceleration in Healthy Volunteers |
| title | Chapter Broadband NIRS Cerebral Evaluation of the Hemodynamic and Oxidative State of Cytochrome-c-Oxidase Responses to +Gz Acceleration in Healthy Volunteers |
| title_full | Chapter Broadband NIRS Cerebral Evaluation of the Hemodynamic and Oxidative State of Cytochrome-c-Oxidase Responses to +Gz Acceleration in Healthy Volunteers |
| title_fullStr | Chapter Broadband NIRS Cerebral Evaluation of the Hemodynamic and Oxidative State of Cytochrome-c-Oxidase Responses to +Gz Acceleration in Healthy Volunteers |
| title_full_unstemmed | Chapter Broadband NIRS Cerebral Evaluation of the Hemodynamic and Oxidative State of Cytochrome-c-Oxidase Responses to +Gz Acceleration in Healthy Volunteers |
| title_short | Chapter Broadband NIRS Cerebral Evaluation of the Hemodynamic and Oxidative State of Cytochrome-c-Oxidase Responses to +Gz Acceleration in Healthy Volunteers |
| title_sort | chapter broadband nirs cerebral evaluation of the hemodynamic and oxidative state of cytochrome c oxidase responses to gz acceleration in healthy volunteers |
| topic | NIRS, Broadband, Cytochrome-c-oxidase, Ischaemia, Human centrifuge |
| topic_facet | NIRS, Broadband, Cytochrome-c-oxidase, Ischaemia, Human centrifuge |
| url | https://library.oapen.org/handle/20.500.12657/56699 |
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