Chapter Near-Infrared Spectroscopy Measured Cerebral Blood Flow from Spontaneous Oxygenation Changes in Neonatal Brain Injury
Neonates with hypoxic-ischaemic (HI) brain injury were monitored using a broadband near-infrared spectroscopy (NIRS) system in the neonatal intensive care unit. The aim of this work is to use the NIRS cerebral oxygenation data (HbD = oxygenated-haemoglobin – deoxygenated-haemoglobin) combined wi...
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Springer Nature
2022
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| Առցանց հասանելիություն: | https://library.oapen.org/handle/20.500.12657/56697 |
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| _version_ | 1869526823717568512 |
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| author | Bale, Gemma Taylor, Nathan Mitra, Subhabrata Sudakou, Aleh Roever, Isabel de Meek, Judith Robertson, Nicola Tachtsidis, Ilias |
| author_browse | Bale, Gemma Meek, Judith Mitra, Subhabrata Robertson, Nicola Roever, Isabel de Sudakou, Aleh Tachtsidis, Ilias Taylor, Nathan |
| author_facet | Bale, Gemma Taylor, Nathan Mitra, Subhabrata Sudakou, Aleh Roever, Isabel de Meek, Judith Robertson, Nicola Tachtsidis, Ilias |
| author_sort | Bale, Gemma |
| collection | Directory of Open Access Books |
| description | Neonates with hypoxic-ischaemic (HI) brain injury were monitored
using a broadband near-infrared spectroscopy (NIRS) system in the neonatal intensive
care unit. The aim of this work is to use the NIRS cerebral oxygenation data
(HbD = oxygenated-haemoglobin
– deoxygenated-haemoglobin) combined with
arterial saturation (SaO2) from pulse oximetry to calculate cerebral blood flow
(CBF) based on the oxygen swing method, during spontaneous desaturation episodes.
The method is based on Fick’s principle and uses HbD as a tracer; when a
sudden change in SaO2 occurs, the change in HbD represents a change in tracer
concentration, and thus it is possible to estimate CBF. CBF was successfully calculated
with broadband NIRS in 11 HIE infants (3 with severe injury) for 70 oxygenation
events on the day of birth. The average CBF was 18.0 ± 12.7 ml 100 g−1 min−1
with a range of 4 ml 100 g−1 min−1 to 60 ml 100 g−1 min−1. For infants with severe
HIE (as determined by magnetic resonance spectroscopy) CBF was significantly
lower (p = 0.038, d = 1.35) than those with moderate HIE on the day of birth. |
| format | Online |
| id | doab-20.500.12854ir-84056 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2022 |
| publishDateRange | 2022 |
| publishDateSort | 2022 |
| publisher | Springer Nature |
| publisherStr | Springer Nature |
| record_format | ojs |
| spelling | doab-20.500.12854ir-840562025-01-23T23:24:55Z Chapter Near-Infrared Spectroscopy Measured Cerebral Blood Flow from Spontaneous Oxygenation Changes in Neonatal Brain Injury Bale, Gemma Taylor, Nathan Mitra, Subhabrata Sudakou, Aleh Roever, Isabel de Meek, Judith Robertson, Nicola Tachtsidis, Ilias Near-infrared spectroscopy; Cerebral blood flow; Neonatal brain injury; Hypoxic-ischaemic encephalopathy; Clinical Neonates with hypoxic-ischaemic (HI) brain injury were monitored using a broadband near-infrared spectroscopy (NIRS) system in the neonatal intensive care unit. The aim of this work is to use the NIRS cerebral oxygenation data (HbD = oxygenated-haemoglobin – deoxygenated-haemoglobin) combined with arterial saturation (SaO2) from pulse oximetry to calculate cerebral blood flow (CBF) based on the oxygen swing method, during spontaneous desaturation episodes. The method is based on Fick’s principle and uses HbD as a tracer; when a sudden change in SaO2 occurs, the change in HbD represents a change in tracer concentration, and thus it is possible to estimate CBF. CBF was successfully calculated with broadband NIRS in 11 HIE infants (3 with severe injury) for 70 oxygenation events on the day of birth. The average CBF was 18.0 ± 12.7 ml 100 g−1 min−1 with a range of 4 ml 100 g−1 min−1 to 60 ml 100 g−1 min−1. For infants with severe HIE (as determined by magnetic resonance spectroscopy) CBF was significantly lower (p = 0.038, d = 1.35) than those with moderate HIE on the day of birth. 2022-06-10T04:30:37Z 2022-06-10T04:30:37Z 2022-06-09T12:26:03Z 2020 chapter https://library.oapen.org/handle/20.500.12657/56697 9783030344597 https://directory.doabooks.org/handle/20.500.12854/84056 eng open access image/jpeg image/jpeg Attribution 4.0 International Attribution 4.0 International https://library.oapen.org/bitstream/20.500.12657/56697/1/Bookshelf_NBK572925.pdf https://library.oapen.org/bitstream/20.500.12657/56697/1/Bookshelf_NBK572925.pdf Springer Nature 10.1007/978-3-030-34461-0_1 10.1007/978-3-030-34461-0_1 9fa3421d-f917-4153-b9ab-fc337c396b5a Oxygen Transport to Tissue XLI Wellcome Trust d859fbd3-d884-4090-a0ec-baf821c9abfd 9783030344597 Wellcome 7 open access |
| spellingShingle | Near-infrared spectroscopy; Cerebral blood flow; Neonatal brain injury; Hypoxic-ischaemic encephalopathy; Clinical Bale, Gemma Taylor, Nathan Mitra, Subhabrata Sudakou, Aleh Roever, Isabel de Meek, Judith Robertson, Nicola Tachtsidis, Ilias Chapter Near-Infrared Spectroscopy Measured Cerebral Blood Flow from Spontaneous Oxygenation Changes in Neonatal Brain Injury |
| title | Chapter Near-Infrared Spectroscopy Measured Cerebral Blood Flow from Spontaneous Oxygenation Changes in Neonatal Brain Injury |
| title_full | Chapter Near-Infrared Spectroscopy Measured Cerebral Blood Flow from Spontaneous Oxygenation Changes in Neonatal Brain Injury |
| title_fullStr | Chapter Near-Infrared Spectroscopy Measured Cerebral Blood Flow from Spontaneous Oxygenation Changes in Neonatal Brain Injury |
| title_full_unstemmed | Chapter Near-Infrared Spectroscopy Measured Cerebral Blood Flow from Spontaneous Oxygenation Changes in Neonatal Brain Injury |
| title_short | Chapter Near-Infrared Spectroscopy Measured Cerebral Blood Flow from Spontaneous Oxygenation Changes in Neonatal Brain Injury |
| title_sort | chapter near infrared spectroscopy measured cerebral blood flow from spontaneous oxygenation changes in neonatal brain injury |
| topic | Near-infrared spectroscopy; Cerebral blood flow; Neonatal brain injury; Hypoxic-ischaemic encephalopathy; Clinical |
| topic_facet | Near-infrared spectroscopy; Cerebral blood flow; Neonatal brain injury; Hypoxic-ischaemic encephalopathy; Clinical |
| url | https://library.oapen.org/handle/20.500.12657/56697 |
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