Albumin-Based Drug Delivery Systems
Albumin is playing an increasing role as a versatile, biodegradable drug carrier in clinical theranostics. By applying different techniques, smart drug-delivery systems can be developed from albumin in order to improve drug delivery of different active pharmaceutical ingredients, even small-molecule...
שמור ב:
| פורמט: | Online |
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| שפה: | אנגלית |
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MDPI - Multidisciplinary Digital Publishing Institute
2022
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| נושאים: | |
| גישה מקוונת: | ONIX_20220621_9783036541082_10 |
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| _version_ | 1869527583302877184 |
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| collection | Directory of Open Access Books |
| description | Albumin is playing an increasing role as a versatile, biodegradable drug carrier in clinical theranostics. By applying different techniques, smart drug-delivery systems can be developed from albumin in order to improve drug delivery of different active pharmaceutical ingredients, even small-molecule drugs, peptides or enzymes. Principally, three drug delivery technologies can be distinguished for binding small-molecule or peptide drugs through the charged amino acids, carboxyl, and amino groups of albumin: physical or covalent binding of the drug to albumin through a ligand- or protein-binding group, the fusion of drug with albumin or the encapsulation of drugs into albumin nanoparticles. The accumulation of albumin in inflamed tissues and solid tumours forms the rationale for developing albumin-based drug delivery systems for targeted drug delivery. Besides tumour therapy, albumin-based drug delivery systems can be successfully applied as anti-inflammatory and anti-thrombotic coating for medical devices. The development and optimization of albumin nanoparticles may also be a rational and promising tool for conventional or alternative administration routes in order to improve therapy. This collection provides an overview of the significant scientific research works in this field, which may inspire researchers towards further development and utilization of these smart drug delivery systems. |
| format | Online |
| id | doab-20.500.12854ir-84432 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2022 |
| publishDateRange | 2022 |
| publishDateSort | 2022 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-844322024-03-31T13:10:25Z Albumin-Based Drug Delivery Systems Katona, Gábor plasma half-life extension albumin conjugation in vivo glucose-lowering activity glucagon-like peptide-1 quality by design rapid equilibrium dialysis muco-adhesion brain PAMPA RPMI 2650 nasal epithelial cell human serum albumin dimerization doxorubicin enhanced permeability and retention effect antitumor Arthrobacter globiformis gout half-life extension inverse electron demand Diels-Alder reaction site-specific albumin conjugation thermostability urate oxidase albumin anti-thrombotic CD39 coating of medical devices stent coating therapeutic fusion protein conjugates vanadium cancer prodrug hydrogels EPR/ESR spectroscopy release behavior disulfide glioma conjugate albumin binding moieties peptides Evans blue 4-(p-iodophenyl)butyric acid integrin αvβ6 integrin αvβ6 binding peptide improved pharmacokinetics PET imaging thema EDItEUR::M Medicine and Nursing thema EDItEUR::K Economics, Finance, Business and Management::KN Industry and industrial studies::KND Manufacturing industries Albumin is playing an increasing role as a versatile, biodegradable drug carrier in clinical theranostics. By applying different techniques, smart drug-delivery systems can be developed from albumin in order to improve drug delivery of different active pharmaceutical ingredients, even small-molecule drugs, peptides or enzymes. Principally, three drug delivery technologies can be distinguished for binding small-molecule or peptide drugs through the charged amino acids, carboxyl, and amino groups of albumin: physical or covalent binding of the drug to albumin through a ligand- or protein-binding group, the fusion of drug with albumin or the encapsulation of drugs into albumin nanoparticles. The accumulation of albumin in inflamed tissues and solid tumours forms the rationale for developing albumin-based drug delivery systems for targeted drug delivery. Besides tumour therapy, albumin-based drug delivery systems can be successfully applied as anti-inflammatory and anti-thrombotic coating for medical devices. The development and optimization of albumin nanoparticles may also be a rational and promising tool for conventional or alternative administration routes in order to improve therapy. This collection provides an overview of the significant scientific research works in this field, which may inspire researchers towards further development and utilization of these smart drug delivery systems. 2022-06-21T08:35:34Z 2022-06-21T08:35:34Z 2022 book ONIX_20220621_9783036541082_10 9783036541082 9783036541075 https://directory.doabooks.org/handle/20.500.12854/84432 eng application/octet-stream Attribution 4.0 International https://mdpi.com/books/pdfview/book/5415 https://mdpi.com/books/pdfview/book/5415 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-0365-4107-5 10.3390/books978-3-0365-4107-5 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783036541082 9783036541075 162 Basel open access |
| spellingShingle | plasma half-life extension albumin conjugation in vivo glucose-lowering activity glucagon-like peptide-1 quality by design rapid equilibrium dialysis muco-adhesion brain PAMPA RPMI 2650 nasal epithelial cell human serum albumin dimerization doxorubicin enhanced permeability and retention effect antitumor Arthrobacter globiformis gout half-life extension inverse electron demand Diels-Alder reaction site-specific albumin conjugation thermostability urate oxidase albumin anti-thrombotic CD39 coating of medical devices stent coating therapeutic fusion protein conjugates vanadium cancer prodrug hydrogels EPR/ESR spectroscopy release behavior disulfide glioma conjugate albumin binding moieties peptides Evans blue 4-(p-iodophenyl)butyric acid integrin αvβ6 integrin αvβ6 binding peptide improved pharmacokinetics PET imaging thema EDItEUR::M Medicine and Nursing thema EDItEUR::K Economics, Finance, Business and Management::KN Industry and industrial studies::KND Manufacturing industries Albumin-Based Drug Delivery Systems |
| title | Albumin-Based Drug Delivery Systems |
| title_full | Albumin-Based Drug Delivery Systems |
| title_fullStr | Albumin-Based Drug Delivery Systems |
| title_full_unstemmed | Albumin-Based Drug Delivery Systems |
| title_short | Albumin-Based Drug Delivery Systems |
| title_sort | albumin based drug delivery systems |
| topic | plasma half-life extension albumin conjugation in vivo glucose-lowering activity glucagon-like peptide-1 quality by design rapid equilibrium dialysis muco-adhesion brain PAMPA RPMI 2650 nasal epithelial cell human serum albumin dimerization doxorubicin enhanced permeability and retention effect antitumor Arthrobacter globiformis gout half-life extension inverse electron demand Diels-Alder reaction site-specific albumin conjugation thermostability urate oxidase albumin anti-thrombotic CD39 coating of medical devices stent coating therapeutic fusion protein conjugates vanadium cancer prodrug hydrogels EPR/ESR spectroscopy release behavior disulfide glioma conjugate albumin binding moieties peptides Evans blue 4-(p-iodophenyl)butyric acid integrin αvβ6 integrin αvβ6 binding peptide improved pharmacokinetics PET imaging thema EDItEUR::M Medicine and Nursing thema EDItEUR::K Economics, Finance, Business and Management::KN Industry and industrial studies::KND Manufacturing industries |
| topic_facet | plasma half-life extension albumin conjugation in vivo glucose-lowering activity glucagon-like peptide-1 quality by design rapid equilibrium dialysis muco-adhesion brain PAMPA RPMI 2650 nasal epithelial cell human serum albumin dimerization doxorubicin enhanced permeability and retention effect antitumor Arthrobacter globiformis gout half-life extension inverse electron demand Diels-Alder reaction site-specific albumin conjugation thermostability urate oxidase albumin anti-thrombotic CD39 coating of medical devices stent coating therapeutic fusion protein conjugates vanadium cancer prodrug hydrogels EPR/ESR spectroscopy release behavior disulfide glioma conjugate albumin binding moieties peptides Evans blue 4-(p-iodophenyl)butyric acid integrin αvβ6 integrin αvβ6 binding peptide improved pharmacokinetics PET imaging thema EDItEUR::M Medicine and Nursing thema EDItEUR::K Economics, Finance, Business and Management::KN Industry and industrial studies::KND Manufacturing industries |
| url | ONIX_20220621_9783036541082_10 |