Down Syndrome
Down syndrome (DS), caused by the triplication of chromosome 21, is the most common genetic cause of intellectual disability (ID). Individuals with DS commonly exhibit unique neuropsychological profiles that emerge during specific developmental stages across the lifespan, often characterized by earl...
Sábháilte in:
| Formáid: | Online |
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| Teanga: | Béarla |
| Foilsithe / Cruthaithe: |
MDPI - Multidisciplinary Digital Publishing Institute
2022
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| Ábhair: | |
| Rochtain ar líne: | ONIX_20220621_9783036539621_26 |
| Clibeanna: |
Níl clibeanna ann, Bí ar an gcéad duine le clib a chur leis an taifead seo!
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| _version_ | 1869526499646767104 |
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| collection | Directory of Open Access Books |
| description | Down syndrome (DS), caused by the triplication of chromosome 21, is the most common genetic cause of intellectual disability (ID). Individuals with DS commonly exhibit unique neuropsychological profiles that emerge during specific developmental stages across the lifespan, often characterized by early developmental delay, cognitive strengths and weaknesses, behavior and mental health issues, and age-related cognitive decline, frequently resulting in early-onset Alzheimer’s disease. These profiles are unique compared to other individuals with ID and reflect the genetic mechanisms and neuroanatomic features underlying the distinct neuropsychological phenotype associated with DS. This Special Issue aims to highlight the recent advancements in understanding the neuropsychological phenotype associated with DS across the lifespan. The lifespan perspective will cover four developmental stages: (1) early childhood; (2) school age; (3) young adulthood, and (4) older adulthood. Authors contributed cutting-edge original research studies and comprehensive reviews that address a broad range of topics related to DS, including early developmental trajectories, cognitive functioning, language, adaptive skills, behavior and mental health, assessment and diagnosis, age-related cognitive decline, and medical issues related to the neuropsychological phenotype and neuroimaging. |
| format | Online |
| id | doab-20.500.12854ir-84448 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2022 |
| publishDateRange | 2022 |
| publishDateSort | 2022 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-844482024-03-31T13:08:32Z Down Syndrome Pulsifer, Margaret B. trisomy 21 decoding vocabulary letters phonological awareness down syndrome fluency disfluency co-occurrence comorbidity language Down syndrome social cognition social behavior measurement children attention audiovisual processing communicative abilities in infants Trisomy 21 independence transition to adulthood proxy-report regression Alzheimer’s disease biomarkers dementia cognition functional independence neuropsychological assessment primary care screening early regression idiopathic regression depression selective serotonin reuptake inhibitor mild cognitive impairment cognitive decline neuropsychological tests cognitive function early-onset Alzheimer disease late-onset Alzheimer disease hypothyroidism thyroid autoantibodies TSH Free T4 APOE Ɛ4 autism spectrum disorder co-occurring prevalence n/a thema EDItEUR::M Medicine and Nursing thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences Down syndrome (DS), caused by the triplication of chromosome 21, is the most common genetic cause of intellectual disability (ID). Individuals with DS commonly exhibit unique neuropsychological profiles that emerge during specific developmental stages across the lifespan, often characterized by early developmental delay, cognitive strengths and weaknesses, behavior and mental health issues, and age-related cognitive decline, frequently resulting in early-onset Alzheimer’s disease. These profiles are unique compared to other individuals with ID and reflect the genetic mechanisms and neuroanatomic features underlying the distinct neuropsychological phenotype associated with DS. This Special Issue aims to highlight the recent advancements in understanding the neuropsychological phenotype associated with DS across the lifespan. The lifespan perspective will cover four developmental stages: (1) early childhood; (2) school age; (3) young adulthood, and (4) older adulthood. Authors contributed cutting-edge original research studies and comprehensive reviews that address a broad range of topics related to DS, including early developmental trajectories, cognitive functioning, language, adaptive skills, behavior and mental health, assessment and diagnosis, age-related cognitive decline, and medical issues related to the neuropsychological phenotype and neuroimaging. 2022-06-21T08:36:20Z 2022-06-21T08:36:20Z 2022 book ONIX_20220621_9783036539621_26 9783036539621 9783036539614 https://directory.doabooks.org/handle/20.500.12854/84448 eng application/octet-stream Attribution 4.0 International https://mdpi.com/books/pdfview/book/5431 https://mdpi.com/books/pdfview/book/5431 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-0365-3961-4 10.3390/books978-3-0365-3961-4 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783036539621 9783036539614 180 Basel open access |
| spellingShingle | trisomy 21 decoding vocabulary letters phonological awareness down syndrome fluency disfluency co-occurrence comorbidity language Down syndrome social cognition social behavior measurement children attention audiovisual processing communicative abilities in infants Trisomy 21 independence transition to adulthood proxy-report regression Alzheimer’s disease biomarkers dementia cognition functional independence neuropsychological assessment primary care screening early regression idiopathic regression depression selective serotonin reuptake inhibitor mild cognitive impairment cognitive decline neuropsychological tests cognitive function early-onset Alzheimer disease late-onset Alzheimer disease hypothyroidism thyroid autoantibodies TSH Free T4 APOE Ɛ4 autism spectrum disorder co-occurring prevalence n/a thema EDItEUR::M Medicine and Nursing thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences Down Syndrome |
| title | Down Syndrome |
| title_full | Down Syndrome |
| title_fullStr | Down Syndrome |
| title_full_unstemmed | Down Syndrome |
| title_short | Down Syndrome |
| title_sort | down syndrome |
| topic | trisomy 21 decoding vocabulary letters phonological awareness down syndrome fluency disfluency co-occurrence comorbidity language Down syndrome social cognition social behavior measurement children attention audiovisual processing communicative abilities in infants Trisomy 21 independence transition to adulthood proxy-report regression Alzheimer’s disease biomarkers dementia cognition functional independence neuropsychological assessment primary care screening early regression idiopathic regression depression selective serotonin reuptake inhibitor mild cognitive impairment cognitive decline neuropsychological tests cognitive function early-onset Alzheimer disease late-onset Alzheimer disease hypothyroidism thyroid autoantibodies TSH Free T4 APOE Ɛ4 autism spectrum disorder co-occurring prevalence n/a thema EDItEUR::M Medicine and Nursing thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences |
| topic_facet | trisomy 21 decoding vocabulary letters phonological awareness down syndrome fluency disfluency co-occurrence comorbidity language Down syndrome social cognition social behavior measurement children attention audiovisual processing communicative abilities in infants Trisomy 21 independence transition to adulthood proxy-report regression Alzheimer’s disease biomarkers dementia cognition functional independence neuropsychological assessment primary care screening early regression idiopathic regression depression selective serotonin reuptake inhibitor mild cognitive impairment cognitive decline neuropsychological tests cognitive function early-onset Alzheimer disease late-onset Alzheimer disease hypothyroidism thyroid autoantibodies TSH Free T4 APOE Ɛ4 autism spectrum disorder co-occurring prevalence n/a thema EDItEUR::M Medicine and Nursing thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences |
| url | ONIX_20220621_9783036539621_26 |