Derivatization in Analytical Chemistry

Derivatization is one of the most widely used sample pretreatment techniques in Analytical Chemistry and Chemical Analysis. Reagent-based or reagent-less schemes offer improved detectability of target compounds, modification of the chromatographic properties and/or the stabilization of sensitive com...

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Publicado: MDPI - Multidisciplinary Digital Publishing Institute 2022
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description Derivatization is one of the most widely used sample pretreatment techniques in Analytical Chemistry and Chemical Analysis. Reagent-based or reagent-less schemes offer improved detectability of target compounds, modification of the chromatographic properties and/or the stabilization of sensitive compounds until analysis. Either coupled with separation techniques or as a “stand alone” analytical procedure, derivatization offers endless possibilities in all aspects of analytical applications.
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id doab-20.500.12854ir-84498
institution Directory of Open Access Books
language eng
publishDate 2022
publishDateRange 2022
publishDateSort 2022
publisher MDPI - Multidisciplinary Digital Publishing Institute
publisherStr MDPI - Multidisciplinary Digital Publishing Institute
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spelling doab-20.500.12854ir-844982024-03-28T03:33:01Z Derivatization in Analytical Chemistry Tzanavaras, Paraskevas D. tyrosine kinase inhibitors chloranilic acid charge-transfer reaction 96-microwell spectrophotometric assay high-throughput pharmaceutical analysis biogenic amines Lycium barbarum L. HPLC derivatization amino acids esterification GC–MS pentafluoropropionic anhydride stability toluene pigment linseed oil derivatisation quantification P/S ratio A/P ratio ∑D GC-MS ureide BSTFA creatine creatinine silylation TMS validation low-molecular-weight thiols human serum albumin α-lipoic acid blood plasma monobromobimane reduction sodium borohydride high-performance liquid chromatography fluorescence detection taurine glutamine clams high-resolution mass spectrometry nerve agents methylation chemical warfare agents sarin Novichoks 2-naphthalenethiol sulforaphane HPLC-UV/Vis pharmacokinetics acetonitrile-related adducts acetylenic lipids double and triple bond localization in-source derivatization mass spectrometry acetazolamide carbonic anhydrase enhancement inhibition pentafluorobenzyl bromide chiral metabolomics rice water d-amino acids enantiomer separation dimethyl labeling homocysteine thiolactone homocysteine zone fluidics o-phthalaldehyde fluorosurfactant-modified gold nanoparticles thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PN Chemistry thema EDItEUR::P Mathematics and Science::PN Chemistry::PNF Analytical chemistry Derivatization is one of the most widely used sample pretreatment techniques in Analytical Chemistry and Chemical Analysis. Reagent-based or reagent-less schemes offer improved detectability of target compounds, modification of the chromatographic properties and/or the stabilization of sensitive compounds until analysis. Either coupled with separation techniques or as a “stand alone” analytical procedure, derivatization offers endless possibilities in all aspects of analytical applications. 2022-06-21T08:38:45Z 2022-06-21T08:38:45Z 2022 book ONIX_20220621_9783036542560_76 9783036542560 9783036542553 https://directory.doabooks.org/handle/20.500.12854/84498 eng application/octet-stream Attribution 4.0 International https://mdpi.com/books/pdfview/book/5481 https://mdpi.com/books/pdfview/book/5481 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-0365-4255-3 10.3390/books978-3-0365-4255-3 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783036542560 9783036542553 210 Basel open access
spellingShingle tyrosine kinase inhibitors
chloranilic acid
charge-transfer reaction
96-microwell spectrophotometric assay
high-throughput pharmaceutical analysis
biogenic amines
Lycium barbarum L.
HPLC
derivatization
amino acids
esterification
GC–MS
pentafluoropropionic anhydride
stability
toluene
pigment
linseed oil
derivatisation
quantification
P/S ratio
A/P ratio
∑D
GC-MS
ureide
BSTFA
creatine
creatinine
silylation
TMS
validation
low-molecular-weight thiols
human serum albumin
α-lipoic acid
blood plasma
monobromobimane
reduction
sodium borohydride
high-performance liquid chromatography
fluorescence detection
taurine
glutamine
clams
high-resolution mass spectrometry
nerve agents
methylation
chemical warfare agents
sarin
Novichoks
2-naphthalenethiol
sulforaphane
HPLC-UV/Vis
pharmacokinetics
acetonitrile-related adducts
acetylenic lipids
double and triple bond localization
in-source derivatization
mass spectrometry
acetazolamide
carbonic anhydrase
enhancement
inhibition
pentafluorobenzyl bromide
chiral metabolomics
rice water
d-amino acids
enantiomer separation
dimethyl labeling
homocysteine thiolactone
homocysteine
zone fluidics
o-phthalaldehyde
fluorosurfactant-modified gold nanoparticles
thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general
thema EDItEUR::P Mathematics and Science::PN Chemistry
thema EDItEUR::P Mathematics and Science::PN Chemistry::PNF Analytical chemistry
Derivatization in Analytical Chemistry
title Derivatization in Analytical Chemistry
title_full Derivatization in Analytical Chemistry
title_fullStr Derivatization in Analytical Chemistry
title_full_unstemmed Derivatization in Analytical Chemistry
title_short Derivatization in Analytical Chemistry
title_sort derivatization in analytical chemistry
topic tyrosine kinase inhibitors
chloranilic acid
charge-transfer reaction
96-microwell spectrophotometric assay
high-throughput pharmaceutical analysis
biogenic amines
Lycium barbarum L.
HPLC
derivatization
amino acids
esterification
GC–MS
pentafluoropropionic anhydride
stability
toluene
pigment
linseed oil
derivatisation
quantification
P/S ratio
A/P ratio
∑D
GC-MS
ureide
BSTFA
creatine
creatinine
silylation
TMS
validation
low-molecular-weight thiols
human serum albumin
α-lipoic acid
blood plasma
monobromobimane
reduction
sodium borohydride
high-performance liquid chromatography
fluorescence detection
taurine
glutamine
clams
high-resolution mass spectrometry
nerve agents
methylation
chemical warfare agents
sarin
Novichoks
2-naphthalenethiol
sulforaphane
HPLC-UV/Vis
pharmacokinetics
acetonitrile-related adducts
acetylenic lipids
double and triple bond localization
in-source derivatization
mass spectrometry
acetazolamide
carbonic anhydrase
enhancement
inhibition
pentafluorobenzyl bromide
chiral metabolomics
rice water
d-amino acids
enantiomer separation
dimethyl labeling
homocysteine thiolactone
homocysteine
zone fluidics
o-phthalaldehyde
fluorosurfactant-modified gold nanoparticles
thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general
thema EDItEUR::P Mathematics and Science::PN Chemistry
thema EDItEUR::P Mathematics and Science::PN Chemistry::PNF Analytical chemistry
topic_facet tyrosine kinase inhibitors
chloranilic acid
charge-transfer reaction
96-microwell spectrophotometric assay
high-throughput pharmaceutical analysis
biogenic amines
Lycium barbarum L.
HPLC
derivatization
amino acids
esterification
GC–MS
pentafluoropropionic anhydride
stability
toluene
pigment
linseed oil
derivatisation
quantification
P/S ratio
A/P ratio
∑D
GC-MS
ureide
BSTFA
creatine
creatinine
silylation
TMS
validation
low-molecular-weight thiols
human serum albumin
α-lipoic acid
blood plasma
monobromobimane
reduction
sodium borohydride
high-performance liquid chromatography
fluorescence detection
taurine
glutamine
clams
high-resolution mass spectrometry
nerve agents
methylation
chemical warfare agents
sarin
Novichoks
2-naphthalenethiol
sulforaphane
HPLC-UV/Vis
pharmacokinetics
acetonitrile-related adducts
acetylenic lipids
double and triple bond localization
in-source derivatization
mass spectrometry
acetazolamide
carbonic anhydrase
enhancement
inhibition
pentafluorobenzyl bromide
chiral metabolomics
rice water
d-amino acids
enantiomer separation
dimethyl labeling
homocysteine thiolactone
homocysteine
zone fluidics
o-phthalaldehyde
fluorosurfactant-modified gold nanoparticles
thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general
thema EDItEUR::P Mathematics and Science::PN Chemistry
thema EDItEUR::P Mathematics and Science::PN Chemistry::PNF Analytical chemistry
url ONIX_20220621_9783036542560_76