Biomimetic Radical Chemistry and Applications 2021
The high importance of free radical chemistry for a variety of biological events, including ageing and inflammation, has attracted considerable interest in understanding the related mechanistic steps at the molecular level. Modelling the free radical chemical reactivity of biological systems is an i...
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| 格式: | Online |
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| 語言: | 英语 |
| 出版: |
MDPI - Multidisciplinary Digital Publishing Institute
2022
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| 在線閱讀: | ONIX_20220621_9783036543505_93 |
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| _version_ | 1869515089167515648 |
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| collection | Directory of Open Access Books |
| description | The high importance of free radical chemistry for a variety of biological events, including ageing and inflammation, has attracted considerable interest in understanding the related mechanistic steps at the molecular level. Modelling the free radical chemical reactivity of biological systems is an important research area. When studying free-radical-based chemical mechanisms, biomimetic chemistry and the design of established biomimetic models come into play to perform experiments in a controlled environment, suitably designed to be a similar as possible to cellular conditions. This Special Issue provides readers with a wide overview of biomimetic radical chemistry, where molecular mechanisms have been defined and molecular libraries of products are developed to be used as traces for the discoveries of some relevant biological processes. Several subjects are presented, with five articles and five reviews written by specialists in the fields of DNA, proteins, lipids, biotechnological applications and bioinspired synthesis, with “free radicals” as the common denominator. |
| format | Online |
| id | doab-20.500.12854ir-84515 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2022 |
| publishDateRange | 2022 |
| publishDateSort | 2022 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-845152024-03-28T03:33:03Z Biomimetic Radical Chemistry and Applications 2021 Chatgilialoglu, Chryssostomos guanine guanyl radical tautomerism guanine radical cation oligonucleotides DNA G-quadruplex time-resolved spectroscopies reactive oxygen species (ROS) oxidation catalase mimics peroxide diiron-peroxo complexes structure/activity kinetic studies biomimetic chemistry cysteine ketone reduction free radicals pulse radiolysis kinetics DNA oxidation DNA hole transfer molecular dynamics quantum dynamics electron transfer charge transfer quantum coherence chemiluminescence reaction mechanisms singlet oxygen reactive oxygen species light emission crosslink dimerization protein oxidation radicals di-tyrosine di-tryptophan disulfides thiols aggregation proteomics mass spectrometry collagen riboflavin hyaluronic acid EPR spectroscopy keratoconus STEM DNA biosensor chemical nucleases DNA-drug interaction copper complexes metallodrugs MEP pathway antibiotics IspH LytB [4Fe-4S] cluster reductive dehydroxylation bioorganometallic intermediate inhibitors methionine neighboring group effect hydroxyl radical triplet state of carboxybenzophenone one-electron oxidants laser flash photolysis peptides proteins n/a thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PN Chemistry thema EDItEUR::P Mathematics and Science::PN Chemistry::PNK Inorganic chemistry The high importance of free radical chemistry for a variety of biological events, including ageing and inflammation, has attracted considerable interest in understanding the related mechanistic steps at the molecular level. Modelling the free radical chemical reactivity of biological systems is an important research area. When studying free-radical-based chemical mechanisms, biomimetic chemistry and the design of established biomimetic models come into play to perform experiments in a controlled environment, suitably designed to be a similar as possible to cellular conditions. This Special Issue provides readers with a wide overview of biomimetic radical chemistry, where molecular mechanisms have been defined and molecular libraries of products are developed to be used as traces for the discoveries of some relevant biological processes. Several subjects are presented, with five articles and five reviews written by specialists in the fields of DNA, proteins, lipids, biotechnological applications and bioinspired synthesis, with “free radicals” as the common denominator. 2022-06-21T08:39:32Z 2022-06-21T08:39:32Z 2022 book ONIX_20220621_9783036543505_93 9783036543505 9783036543499 https://directory.doabooks.org/handle/20.500.12854/84515 eng application/octet-stream Attribution 4.0 International https://mdpi.com/books/pdfview/book/5499 https://mdpi.com/books/pdfview/book/5499 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-0365-4349-9 10.3390/books978-3-0365-4349-9 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783036543505 9783036543499 244 Basel open access |
| spellingShingle | guanine guanyl radical tautomerism guanine radical cation oligonucleotides DNA G-quadruplex time-resolved spectroscopies reactive oxygen species (ROS) oxidation catalase mimics peroxide diiron-peroxo complexes structure/activity kinetic studies biomimetic chemistry cysteine ketone reduction free radicals pulse radiolysis kinetics DNA oxidation DNA hole transfer molecular dynamics quantum dynamics electron transfer charge transfer quantum coherence chemiluminescence reaction mechanisms singlet oxygen reactive oxygen species light emission crosslink dimerization protein oxidation radicals di-tyrosine di-tryptophan disulfides thiols aggregation proteomics mass spectrometry collagen riboflavin hyaluronic acid EPR spectroscopy keratoconus STEM DNA biosensor chemical nucleases DNA-drug interaction copper complexes metallodrugs MEP pathway antibiotics IspH LytB [4Fe-4S] cluster reductive dehydroxylation bioorganometallic intermediate inhibitors methionine neighboring group effect hydroxyl radical triplet state of carboxybenzophenone one-electron oxidants laser flash photolysis peptides proteins n/a thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PN Chemistry thema EDItEUR::P Mathematics and Science::PN Chemistry::PNK Inorganic chemistry Biomimetic Radical Chemistry and Applications 2021 |
| title | Biomimetic Radical Chemistry and Applications 2021 |
| title_full | Biomimetic Radical Chemistry and Applications 2021 |
| title_fullStr | Biomimetic Radical Chemistry and Applications 2021 |
| title_full_unstemmed | Biomimetic Radical Chemistry and Applications 2021 |
| title_short | Biomimetic Radical Chemistry and Applications 2021 |
| title_sort | biomimetic radical chemistry and applications 2021 |
| topic | guanine guanyl radical tautomerism guanine radical cation oligonucleotides DNA G-quadruplex time-resolved spectroscopies reactive oxygen species (ROS) oxidation catalase mimics peroxide diiron-peroxo complexes structure/activity kinetic studies biomimetic chemistry cysteine ketone reduction free radicals pulse radiolysis kinetics DNA oxidation DNA hole transfer molecular dynamics quantum dynamics electron transfer charge transfer quantum coherence chemiluminescence reaction mechanisms singlet oxygen reactive oxygen species light emission crosslink dimerization protein oxidation radicals di-tyrosine di-tryptophan disulfides thiols aggregation proteomics mass spectrometry collagen riboflavin hyaluronic acid EPR spectroscopy keratoconus STEM DNA biosensor chemical nucleases DNA-drug interaction copper complexes metallodrugs MEP pathway antibiotics IspH LytB [4Fe-4S] cluster reductive dehydroxylation bioorganometallic intermediate inhibitors methionine neighboring group effect hydroxyl radical triplet state of carboxybenzophenone one-electron oxidants laser flash photolysis peptides proteins n/a thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PN Chemistry thema EDItEUR::P Mathematics and Science::PN Chemistry::PNK Inorganic chemistry |
| topic_facet | guanine guanyl radical tautomerism guanine radical cation oligonucleotides DNA G-quadruplex time-resolved spectroscopies reactive oxygen species (ROS) oxidation catalase mimics peroxide diiron-peroxo complexes structure/activity kinetic studies biomimetic chemistry cysteine ketone reduction free radicals pulse radiolysis kinetics DNA oxidation DNA hole transfer molecular dynamics quantum dynamics electron transfer charge transfer quantum coherence chemiluminescence reaction mechanisms singlet oxygen reactive oxygen species light emission crosslink dimerization protein oxidation radicals di-tyrosine di-tryptophan disulfides thiols aggregation proteomics mass spectrometry collagen riboflavin hyaluronic acid EPR spectroscopy keratoconus STEM DNA biosensor chemical nucleases DNA-drug interaction copper complexes metallodrugs MEP pathway antibiotics IspH LytB [4Fe-4S] cluster reductive dehydroxylation bioorganometallic intermediate inhibitors methionine neighboring group effect hydroxyl radical triplet state of carboxybenzophenone one-electron oxidants laser flash photolysis peptides proteins n/a thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PN Chemistry thema EDItEUR::P Mathematics and Science::PN Chemistry::PNK Inorganic chemistry |
| url | ONIX_20220621_9783036543505_93 |