MicroRNA and Cancer
MicroRNAs (miRs) are small noncoding RNAs that function as post-transcriptional regulators of gene expression and have important roles in almost all biological pathways. Deregulated miR expression has been detected in numerous cancers, where miRs act as both oncogene and tumor suppressors. Due to th...
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| Format: | Online |
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| Langue: | anglais |
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MDPI - Multidisciplinary Digital Publishing Institute
2022
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| Accès en ligne: | ONIX_20220706_9783036544168_28 |
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| description | MicroRNAs (miRs) are small noncoding RNAs that function as post-transcriptional regulators of gene expression and have important roles in almost all biological pathways. Deregulated miR expression has been detected in numerous cancers, where miRs act as both oncogene and tumor suppressors. Due to their important roles in tumorigenesis, miRs have been investigated as prognostic and diagnostic biomarkers and as useful targets for therapeutic intervention. From a therapeutic point of view, two modalities can serve to rectify gene networks in cancer cells. For oncomiRs, a rational means is downregulation through antagomirs. Moreover, observations of the pathological reductions in tumor-suppressive miRs have inspired the concept of “miR replacement therapy” to enhance the amount of these miRs, thereby restoring them to normal levels. However, the clinical applicability of miR-based therapies is severely limited by the lack of effective delivery systems. Therefore, to understand the role of this new class of regulators, we need to identify the mRNA targets regulated by individual miRs as well as to develop specific, efficient, and safe delivery systems for therapeutic miRs. |
| format | Online |
| id | doab-20.500.12854ir-87433 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2022 |
| publishDateRange | 2022 |
| publishDateSort | 2022 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-874332024-03-28T03:33:14Z MicroRNA and Cancer Tucci, Paola Breast cancer Hypoxia inducible factor 1-alpha (HIF-1α) MicroRNA (miRNA) miR526b miR655 Oxidative stress Migration Cyclooxygenase-2 (COX-2) Prostaglandin E2 receptor 4 (EP4) PI3K/Akt adipokines endometrial cancer estrogens hyperinsulinemia insulin insulin resistance insulin signaling insulin-like growth factors microRNA miRNA ovarian cancer survival prognostic factor serum LDH blood biomarker circulating microRNA plasma immunotherapy immune checkpoint inhibitors metastatic melanoma hepatocellular carcinoma metastasis exosome bioinformatics analysis renal cancer RCC ccRCC meta-analysis miRNAs normal B-cell development B-CLL miRNA-transcription factor network regulation biomarker therapy prognosis diagnosis progression prediction smoking non-small cell lung cancer methylation miR-584-5p YKT6 snoRNA 2′-O-methylation pseudouridylation malignant melanoma cancer stem cell stemness head and neck squamous cell carcinoma colon cancer cancer stem cells microRNAs deformability PARP replication stress targeted therapy breast cancer circulating biomarkers medulloblastoma brain tumour subgroups stem cells n/a thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences MicroRNAs (miRs) are small noncoding RNAs that function as post-transcriptional regulators of gene expression and have important roles in almost all biological pathways. Deregulated miR expression has been detected in numerous cancers, where miRs act as both oncogene and tumor suppressors. Due to their important roles in tumorigenesis, miRs have been investigated as prognostic and diagnostic biomarkers and as useful targets for therapeutic intervention. From a therapeutic point of view, two modalities can serve to rectify gene networks in cancer cells. For oncomiRs, a rational means is downregulation through antagomirs. Moreover, observations of the pathological reductions in tumor-suppressive miRs have inspired the concept of “miR replacement therapy” to enhance the amount of these miRs, thereby restoring them to normal levels. However, the clinical applicability of miR-based therapies is severely limited by the lack of effective delivery systems. Therefore, to understand the role of this new class of regulators, we need to identify the mRNA targets regulated by individual miRs as well as to develop specific, efficient, and safe delivery systems for therapeutic miRs. 2022-07-06T11:49:29Z 2022-07-06T11:49:29Z 2022 book ONIX_20220706_9783036544168_28 9783036544168 9783036544151 https://directory.doabooks.org/handle/20.500.12854/87433 eng application/octet-stream Attribution 4.0 International https://mdpi.com/books/pdfview/book/5621 https://mdpi.com/books/pdfview/book/5621 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-0365-4415-1 10.3390/books978-3-0365-4415-1 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783036544168 9783036544151 298 Basel open access |
| spellingShingle | Breast cancer Hypoxia inducible factor 1-alpha (HIF-1α) MicroRNA (miRNA) miR526b miR655 Oxidative stress Migration Cyclooxygenase-2 (COX-2) Prostaglandin E2 receptor 4 (EP4) PI3K/Akt adipokines endometrial cancer estrogens hyperinsulinemia insulin insulin resistance insulin signaling insulin-like growth factors microRNA miRNA ovarian cancer survival prognostic factor serum LDH blood biomarker circulating microRNA plasma immunotherapy immune checkpoint inhibitors metastatic melanoma hepatocellular carcinoma metastasis exosome bioinformatics analysis renal cancer RCC ccRCC meta-analysis miRNAs normal B-cell development B-CLL miRNA-transcription factor network regulation biomarker therapy prognosis diagnosis progression prediction smoking non-small cell lung cancer methylation miR-584-5p YKT6 snoRNA 2′-O-methylation pseudouridylation malignant melanoma cancer stem cell stemness head and neck squamous cell carcinoma colon cancer cancer stem cells microRNAs deformability PARP replication stress targeted therapy breast cancer circulating biomarkers medulloblastoma brain tumour subgroups stem cells n/a thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences MicroRNA and Cancer |
| title | MicroRNA and Cancer |
| title_full | MicroRNA and Cancer |
| title_fullStr | MicroRNA and Cancer |
| title_full_unstemmed | MicroRNA and Cancer |
| title_short | MicroRNA and Cancer |
| title_sort | microrna and cancer |
| topic | Breast cancer Hypoxia inducible factor 1-alpha (HIF-1α) MicroRNA (miRNA) miR526b miR655 Oxidative stress Migration Cyclooxygenase-2 (COX-2) Prostaglandin E2 receptor 4 (EP4) PI3K/Akt adipokines endometrial cancer estrogens hyperinsulinemia insulin insulin resistance insulin signaling insulin-like growth factors microRNA miRNA ovarian cancer survival prognostic factor serum LDH blood biomarker circulating microRNA plasma immunotherapy immune checkpoint inhibitors metastatic melanoma hepatocellular carcinoma metastasis exosome bioinformatics analysis renal cancer RCC ccRCC meta-analysis miRNAs normal B-cell development B-CLL miRNA-transcription factor network regulation biomarker therapy prognosis diagnosis progression prediction smoking non-small cell lung cancer methylation miR-584-5p YKT6 snoRNA 2′-O-methylation pseudouridylation malignant melanoma cancer stem cell stemness head and neck squamous cell carcinoma colon cancer cancer stem cells microRNAs deformability PARP replication stress targeted therapy breast cancer circulating biomarkers medulloblastoma brain tumour subgroups stem cells n/a thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences |
| topic_facet | Breast cancer Hypoxia inducible factor 1-alpha (HIF-1α) MicroRNA (miRNA) miR526b miR655 Oxidative stress Migration Cyclooxygenase-2 (COX-2) Prostaglandin E2 receptor 4 (EP4) PI3K/Akt adipokines endometrial cancer estrogens hyperinsulinemia insulin insulin resistance insulin signaling insulin-like growth factors microRNA miRNA ovarian cancer survival prognostic factor serum LDH blood biomarker circulating microRNA plasma immunotherapy immune checkpoint inhibitors metastatic melanoma hepatocellular carcinoma metastasis exosome bioinformatics analysis renal cancer RCC ccRCC meta-analysis miRNAs normal B-cell development B-CLL miRNA-transcription factor network regulation biomarker therapy prognosis diagnosis progression prediction smoking non-small cell lung cancer methylation miR-584-5p YKT6 snoRNA 2′-O-methylation pseudouridylation malignant melanoma cancer stem cell stemness head and neck squamous cell carcinoma colon cancer cancer stem cells microRNAs deformability PARP replication stress targeted therapy breast cancer circulating biomarkers medulloblastoma brain tumour subgroups stem cells n/a thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences |
| url | ONIX_20220706_9783036544168_28 |