Synthetic Peptides and Peptidomimetics: From Basic Science to Biomedical Applications
This Special Issue, entitled "Synthetic Peptides and Peptidomimetics: From Basic Science to Biomedical Applications", has included both reviews and original research contributions focused on the chemical design and biomedical applications of structurally modified bioactive peptides. The papers colle...
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| Formato: | Online |
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| Idioma: | inglês |
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MDPI - Multidisciplinary Digital Publishing Institute
2022
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| Acesso em linha: | ONIX_20220706_9783036543963_45 |
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| _version_ | 1869517496551211008 |
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| collection | Directory of Open Access Books |
| description | This Special Issue, entitled "Synthetic Peptides and Peptidomimetics: From Basic Science to Biomedical Applications", has included both reviews and original research contributions focused on the chemical design and biomedical applications of structurally modified bioactive peptides. The papers collected show how successful this class of molecules still is, both as model molecules for studying the structure of proteins and as potential therapeutics and diagnostics, and also as laboratory tools for advanced basic and applied studies. The large scientific community working in this field is in fact very active and productive, and is making the most of the potential and versatility of these molecules to generate increasingly interesting and innovative molecules of therapeutic interest and to understand the fundamental molecular mechanisms of life. |
| format | Online |
| id | doab-20.500.12854ir-87450 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2022 |
| publishDateRange | 2022 |
| publishDateSort | 2022 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-874502024-03-28T03:33:17Z Synthetic Peptides and Peptidomimetics: From Basic Science to Biomedical Applications Doti, Nunzianna Ruvo, Menotti polymers peptidomimetics AFM transfection molecular modelling peptide α-helix hydrocarbon stapling ring-closing metathesis i,i + 1 staple X-ray structure deferoxamine RGD peptides integrins radiodiagnostics PET imaging retro-inverso peptides anticancer peptides drug delivery peptide antigens Aβ IAPP antimicrobial peptides peptides diagnostic ELISA microarray PET SPECT imaging diagnostic non-imaging diagnostic amphiphilic peptides non-viral gene delivery nanocarrier peptide self-assemblies stimuli responsive SARS-CoV-2 FRET molecular docking molecular dynamics MM-GBSA drug repurposing antiviral cancer cyclic peptide integrin αvβ3 ALOS4 melanoma fluorescent peptide environment-sensitive fluorophore peptide labeling luciferin membrane-binding peptide antimicrobial peptide antitumor peptide RGD peptide antiproliferative activity chirality conformational analysis density functional theory (DFT) ferrocene hydrogen bonds peptidomimetic X-ray protein–protein interactions (PPIs) voltage-gated Na+ (Nav) channels fibroblast growth factor 14 (FGF14) medium spiny neurons (MSNs) nucleus accumbens (NAc) neurotherapeutics cyclophilin A (CypA) apoptosis-inducing factor (AIF) human neuroblastoma SH-SY5Y cells staurosporine-mediated cell death AIF(370-394) peptide caspase-3 PARP antifungal antibacterial peptide-based therapies synthetic peptides thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences This Special Issue, entitled "Synthetic Peptides and Peptidomimetics: From Basic Science to Biomedical Applications", has included both reviews and original research contributions focused on the chemical design and biomedical applications of structurally modified bioactive peptides. The papers collected show how successful this class of molecules still is, both as model molecules for studying the structure of proteins and as potential therapeutics and diagnostics, and also as laboratory tools for advanced basic and applied studies. The large scientific community working in this field is in fact very active and productive, and is making the most of the potential and versatility of these molecules to generate increasingly interesting and innovative molecules of therapeutic interest and to understand the fundamental molecular mechanisms of life. 2022-07-06T11:50:20Z 2022-07-06T11:50:20Z 2022 book ONIX_20220706_9783036543963_45 9783036543963 9783036543956 https://directory.doabooks.org/handle/20.500.12854/87450 eng application/octet-stream Attribution 4.0 International https://mdpi.com/books/pdfview/book/5638 https://mdpi.com/books/pdfview/book/5638 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-0365-4395-6 10.3390/books978-3-0365-4395-6 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783036543963 9783036543956 274 Basel open access |
| spellingShingle | polymers peptidomimetics AFM transfection molecular modelling peptide α-helix hydrocarbon stapling ring-closing metathesis i,i + 1 staple X-ray structure deferoxamine RGD peptides integrins radiodiagnostics PET imaging retro-inverso peptides anticancer peptides drug delivery peptide antigens Aβ IAPP antimicrobial peptides peptides diagnostic ELISA microarray PET SPECT imaging diagnostic non-imaging diagnostic amphiphilic peptides non-viral gene delivery nanocarrier peptide self-assemblies stimuli responsive SARS-CoV-2 FRET molecular docking molecular dynamics MM-GBSA drug repurposing antiviral cancer cyclic peptide integrin αvβ3 ALOS4 melanoma fluorescent peptide environment-sensitive fluorophore peptide labeling luciferin membrane-binding peptide antimicrobial peptide antitumor peptide RGD peptide antiproliferative activity chirality conformational analysis density functional theory (DFT) ferrocene hydrogen bonds peptidomimetic X-ray protein–protein interactions (PPIs) voltage-gated Na+ (Nav) channels fibroblast growth factor 14 (FGF14) medium spiny neurons (MSNs) nucleus accumbens (NAc) neurotherapeutics cyclophilin A (CypA) apoptosis-inducing factor (AIF) human neuroblastoma SH-SY5Y cells staurosporine-mediated cell death AIF(370-394) peptide caspase-3 PARP antifungal antibacterial peptide-based therapies synthetic peptides thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences Synthetic Peptides and Peptidomimetics: From Basic Science to Biomedical Applications |
| title | Synthetic Peptides and Peptidomimetics: From Basic Science to Biomedical Applications |
| title_full | Synthetic Peptides and Peptidomimetics: From Basic Science to Biomedical Applications |
| title_fullStr | Synthetic Peptides and Peptidomimetics: From Basic Science to Biomedical Applications |
| title_full_unstemmed | Synthetic Peptides and Peptidomimetics: From Basic Science to Biomedical Applications |
| title_short | Synthetic Peptides and Peptidomimetics: From Basic Science to Biomedical Applications |
| title_sort | synthetic peptides and peptidomimetics from basic science to biomedical applications |
| topic | polymers peptidomimetics AFM transfection molecular modelling peptide α-helix hydrocarbon stapling ring-closing metathesis i,i + 1 staple X-ray structure deferoxamine RGD peptides integrins radiodiagnostics PET imaging retro-inverso peptides anticancer peptides drug delivery peptide antigens Aβ IAPP antimicrobial peptides peptides diagnostic ELISA microarray PET SPECT imaging diagnostic non-imaging diagnostic amphiphilic peptides non-viral gene delivery nanocarrier peptide self-assemblies stimuli responsive SARS-CoV-2 FRET molecular docking molecular dynamics MM-GBSA drug repurposing antiviral cancer cyclic peptide integrin αvβ3 ALOS4 melanoma fluorescent peptide environment-sensitive fluorophore peptide labeling luciferin membrane-binding peptide antimicrobial peptide antitumor peptide RGD peptide antiproliferative activity chirality conformational analysis density functional theory (DFT) ferrocene hydrogen bonds peptidomimetic X-ray protein–protein interactions (PPIs) voltage-gated Na+ (Nav) channels fibroblast growth factor 14 (FGF14) medium spiny neurons (MSNs) nucleus accumbens (NAc) neurotherapeutics cyclophilin A (CypA) apoptosis-inducing factor (AIF) human neuroblastoma SH-SY5Y cells staurosporine-mediated cell death AIF(370-394) peptide caspase-3 PARP antifungal antibacterial peptide-based therapies synthetic peptides thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences |
| topic_facet | polymers peptidomimetics AFM transfection molecular modelling peptide α-helix hydrocarbon stapling ring-closing metathesis i,i + 1 staple X-ray structure deferoxamine RGD peptides integrins radiodiagnostics PET imaging retro-inverso peptides anticancer peptides drug delivery peptide antigens Aβ IAPP antimicrobial peptides peptides diagnostic ELISA microarray PET SPECT imaging diagnostic non-imaging diagnostic amphiphilic peptides non-viral gene delivery nanocarrier peptide self-assemblies stimuli responsive SARS-CoV-2 FRET molecular docking molecular dynamics MM-GBSA drug repurposing antiviral cancer cyclic peptide integrin αvβ3 ALOS4 melanoma fluorescent peptide environment-sensitive fluorophore peptide labeling luciferin membrane-binding peptide antimicrobial peptide antitumor peptide RGD peptide antiproliferative activity chirality conformational analysis density functional theory (DFT) ferrocene hydrogen bonds peptidomimetic X-ray protein–protein interactions (PPIs) voltage-gated Na+ (Nav) channels fibroblast growth factor 14 (FGF14) medium spiny neurons (MSNs) nucleus accumbens (NAc) neurotherapeutics cyclophilin A (CypA) apoptosis-inducing factor (AIF) human neuroblastoma SH-SY5Y cells staurosporine-mediated cell death AIF(370-394) peptide caspase-3 PARP antifungal antibacterial peptide-based therapies synthetic peptides thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences |
| url | ONIX_20220706_9783036543963_45 |