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Advances in Primary Progressive Aphasia

Primary progressive aphasia is a clinical syndrome that includes a group of neurodegenerative disorders characterized by progressive language impairment. Our knowledge about this disorder has evolved significantly in recent years. Notably, correlations between clinical findings and pathology have im...

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Format: Online
Sprog:engelsk
Udgivet: MDPI - Multidisciplinary Digital Publishing Institute 2022
Fag:
primary progressive aphasia
informativeness
speech production
assessment
diagnosis
cognitive approach
dementia
frontotemporal dementia
Alzheimer’s disease
neuropsychology
span
sentence repetition
working memory
phonological
visuospatial
natural history
mortality
survival
memory clinic
graphical markers
graphical parameters
writing pressure
differential diagnosis
longitudinal assessment
cognitive changes
behavioural and psychological symptoms of dementia
level of functioning
electroencephalography
resting-state
biomarkers machine learning
K-Nearest Neighbors
graph theory
treatment
speech and language therapy
intervention
cognitive rehabilitation
bilingualism
semantic dementia
semantic variant primary progressive aphasia
word finding
language therapy
behavioural therapy
electroencephalography (EEG)
network analysis
progressive apraxia of speech
n/a
thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general
thema EDItEUR::P Mathematics and Science::PS Biology, life sciences
Online adgang:ONIX_20220706_9783036544083_54
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Summary:Primary progressive aphasia is a clinical syndrome that includes a group of neurodegenerative disorders characterized by progressive language impairment. Our knowledge about this disorder has evolved significantly in recent years. Notably, correlations between clinical findings and pathology have improved, and main clinical, neuroimaging, and genetic features have been described. Furthermore, primary progressive aphasia is a good model for the study of brain–behavior relationships, and has contributed to the knowledge of the neural basis of language functioning. However, there are many open questions remaining. For instance, classification into three variants (non-fluent, semantic, and logopenic) is under debate; further data about epidemiology and natural history of the diseases are needed; and, as in other neurodegenerative disorders, successful therapies are lacking. The Guest Editors expect that this book can be very useful for scholars.

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