Paradox Role of Oxidative Stress in Cancer
Reactive oxygen species (ROS) are produced by healthy cells and are maintained at physiological levels by antioxidant systems. However, when ROS increase in number, a condition of oxidative stress occurs, leading to many human diseases, including cancer. The relationship between oxidative stress and...
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| Format: | Online |
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| Language: | English |
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MDPI - Multidisciplinary Digital Publishing Institute
2022
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| Online Access: | ONIX_20220706_9783036544212_72 |
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| description | Reactive oxygen species (ROS) are produced by healthy cells and are maintained at physiological levels by antioxidant systems. However, when ROS increase in number, a condition of oxidative stress occurs, leading to many human diseases, including cancer. The relationship between oxidative stress and cancer is complex since ROS play a double-edged role in cancer development and under therapy response. This paradox represents a great challenge for researchers and needs to be investigated. The articles collected in this Special Issue can help to clarify the role of ROS modulation in cancer prevention and treatment, and to dissect the molecular mechanisms underlying its paradoxical role in order to counteract carcinogenesis or enhance sensitivity to anticancer therapy. |
| format | Online |
| id | doab-20.500.12854ir-87477 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2022 |
| publishDateRange | 2022 |
| publishDateSort | 2022 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-874772024-03-31T13:10:42Z Paradox Role of Oxidative Stress in Cancer Domenicotti, Cinzia Marengo, Barbara sonodynamic therapy carbon doped titanium dioxide sonosensitizers ultrasound cancer treatment breast cancer treatment radiotherapy hematological malignancies oxidative stress lymphoma leukemia multiple myeloma apoptosis mitochondria ultraviolet-C (UVC) withanolide combined treatment oral cancer DNA damage cancer therapy immune system Hypericum perforatum hyperforin reactive oxygen species pH regulation tumor prevention tumor therapy cancerogenesis inflammatory signaling natural compounds pancreatic cancer antitumor agents coordination polymers bioinorganic chemistry cold atmospheric plasma reactive oxygen and nitrogen species nitrite cancer stem cells chemoresistance glutathione lipid peroxidation ZEB-1 GPX4 ferroptosis HO-1 Nrf2 cancer progression patients therapy prognosis biomarker Eprenetapopt Erastin glutathione (GSH) SLC7A11 iron NRF2 n/a thema EDItEUR::M Medicine and Nursing thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCL Oncology Reactive oxygen species (ROS) are produced by healthy cells and are maintained at physiological levels by antioxidant systems. However, when ROS increase in number, a condition of oxidative stress occurs, leading to many human diseases, including cancer. The relationship between oxidative stress and cancer is complex since ROS play a double-edged role in cancer development and under therapy response. This paradox represents a great challenge for researchers and needs to be investigated. The articles collected in this Special Issue can help to clarify the role of ROS modulation in cancer prevention and treatment, and to dissect the molecular mechanisms underlying its paradoxical role in order to counteract carcinogenesis or enhance sensitivity to anticancer therapy. 2022-07-06T11:51:38Z 2022-07-06T11:51:38Z 2022 book ONIX_20220706_9783036544212_72 9783036544212 9783036544229 https://directory.doabooks.org/handle/20.500.12854/87477 eng application/octet-stream Attribution 4.0 International https://mdpi.com/books/pdfview/book/5665 https://mdpi.com/books/pdfview/book/5665 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-0365-4422-9 10.3390/books978-3-0365-4422-9 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783036544212 9783036544229 214 Basel open access |
| spellingShingle | sonodynamic therapy carbon doped titanium dioxide sonosensitizers ultrasound cancer treatment breast cancer treatment radiotherapy hematological malignancies oxidative stress lymphoma leukemia multiple myeloma apoptosis mitochondria ultraviolet-C (UVC) withanolide combined treatment oral cancer DNA damage cancer therapy immune system Hypericum perforatum hyperforin reactive oxygen species pH regulation tumor prevention tumor therapy cancerogenesis inflammatory signaling natural compounds pancreatic cancer antitumor agents coordination polymers bioinorganic chemistry cold atmospheric plasma reactive oxygen and nitrogen species nitrite cancer stem cells chemoresistance glutathione lipid peroxidation ZEB-1 GPX4 ferroptosis HO-1 Nrf2 cancer progression patients therapy prognosis biomarker Eprenetapopt Erastin glutathione (GSH) SLC7A11 iron NRF2 n/a thema EDItEUR::M Medicine and Nursing thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCL Oncology Paradox Role of Oxidative Stress in Cancer |
| title | Paradox Role of Oxidative Stress in Cancer |
| title_full | Paradox Role of Oxidative Stress in Cancer |
| title_fullStr | Paradox Role of Oxidative Stress in Cancer |
| title_full_unstemmed | Paradox Role of Oxidative Stress in Cancer |
| title_short | Paradox Role of Oxidative Stress in Cancer |
| title_sort | paradox role of oxidative stress in cancer |
| topic | sonodynamic therapy carbon doped titanium dioxide sonosensitizers ultrasound cancer treatment breast cancer treatment radiotherapy hematological malignancies oxidative stress lymphoma leukemia multiple myeloma apoptosis mitochondria ultraviolet-C (UVC) withanolide combined treatment oral cancer DNA damage cancer therapy immune system Hypericum perforatum hyperforin reactive oxygen species pH regulation tumor prevention tumor therapy cancerogenesis inflammatory signaling natural compounds pancreatic cancer antitumor agents coordination polymers bioinorganic chemistry cold atmospheric plasma reactive oxygen and nitrogen species nitrite cancer stem cells chemoresistance glutathione lipid peroxidation ZEB-1 GPX4 ferroptosis HO-1 Nrf2 cancer progression patients therapy prognosis biomarker Eprenetapopt Erastin glutathione (GSH) SLC7A11 iron NRF2 n/a thema EDItEUR::M Medicine and Nursing thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCL Oncology |
| topic_facet | sonodynamic therapy carbon doped titanium dioxide sonosensitizers ultrasound cancer treatment breast cancer treatment radiotherapy hematological malignancies oxidative stress lymphoma leukemia multiple myeloma apoptosis mitochondria ultraviolet-C (UVC) withanolide combined treatment oral cancer DNA damage cancer therapy immune system Hypericum perforatum hyperforin reactive oxygen species pH regulation tumor prevention tumor therapy cancerogenesis inflammatory signaling natural compounds pancreatic cancer antitumor agents coordination polymers bioinorganic chemistry cold atmospheric plasma reactive oxygen and nitrogen species nitrite cancer stem cells chemoresistance glutathione lipid peroxidation ZEB-1 GPX4 ferroptosis HO-1 Nrf2 cancer progression patients therapy prognosis biomarker Eprenetapopt Erastin glutathione (GSH) SLC7A11 iron NRF2 n/a thema EDItEUR::M Medicine and Nursing thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCL Oncology |
| url | ONIX_20220706_9783036544212_72 |