Toxic Metals, Chronic Diseases and Related Cancers
Long-term exposure to environmental toxicants is estimated to account for 70–90% of the risks of acquiring chronic ailments. Presently, chronic kidney disease and infertility affect a significant proportion of the world population, while research data indicate that exposure to toxic metals may contr...
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| Médium: | Online |
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| Jazyk: | angličtina |
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MDPI - Multidisciplinary Digital Publishing Institute
2022
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| On-line přístup: | ONIX_20220706_9783036541716_103 |
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| collection | Directory of Open Access Books |
| description | Long-term exposure to environmental toxicants is estimated to account for 70–90% of the risks of acquiring chronic ailments. Presently, chronic kidney disease and infertility affect a significant proportion of the world population, while research data indicate that exposure to toxic metals may contribute to the looming statistics. Alarming evidence suggests that exposure to the heavy metal cadmium may affect every stage of life, and exposure in early life may determine susceptibility to certain diseases in adulthood. Prevention of these outcomes requires avoidance of further environmental contamination, minimization of exposure, and reduction of toxic metals in food crops to the lowest achievable levels. |
| format | Online |
| id | doab-20.500.12854ir-87508 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2022 |
| publishDateRange | 2022 |
| publishDateSort | 2022 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-875082024-03-31T13:09:06Z Toxic Metals, Chronic Diseases and Related Cancers Satarug, Soisungwan Trace elements hair children hazardous waste incinerator Constantí (Catalonia, Spain) blood lead level boatyard childhood lead poisoning fishing community lead weights β2-microglobulin cadmium creatinine clearance glomerular filtration N-acetyl-β-d-glucosaminidase nephron mass nephrotoxicity trace elements autopsy tissues temporal trends creatinine excretion glomerular filtration rate lead kidney endocytosis metallothionein flow cytometry proximal tubule epithelial cells OGTT minimal model glucose response mechanism genotoxicity aluminum chloride rats food farmer PTWI (provisional tolerable monthly intake) TWI (tolerable weekly intake) Monte Carlo simulation mercury obesogen lipid profiles hyperlipidemia elevated liver enzymes hexavalent chromium [Cr(VI)] mitochondrial fragmentation dynamin-related protein 1 (Drp1) mitochondrial respiratory chain complex I (MRCC I) reactive oxygen species (ROS) blood lead cellular immunity phagocytosis humoral munity immunosuppression insulin diabetes hyperglycemia hyperinsulinemia lipogenic β-cell toxicity stroke cerebrovascular accident heavy metal rare earth element case-control study mortality lifetime cadmium intake renal diseases urinary cadmium a follow-up study diet kidney function chronic kidney disease threshold limit tolerable intake level heavy metals birth weight preterm birth diet pattern Mediterranean diet pregnancy toxic metals reproduction testicular and ovarian structure n/a thema EDItEUR::M Medicine and Nursing::MB Medicine: general issues::MBN Public health and preventive medicine Long-term exposure to environmental toxicants is estimated to account for 70–90% of the risks of acquiring chronic ailments. Presently, chronic kidney disease and infertility affect a significant proportion of the world population, while research data indicate that exposure to toxic metals may contribute to the looming statistics. Alarming evidence suggests that exposure to the heavy metal cadmium may affect every stage of life, and exposure in early life may determine susceptibility to certain diseases in adulthood. Prevention of these outcomes requires avoidance of further environmental contamination, minimization of exposure, and reduction of toxic metals in food crops to the lowest achievable levels. 2022-07-06T11:53:35Z 2022-07-06T11:53:35Z 2022 book ONIX_20220706_9783036541716_103 9783036541716 9783036541723 https://directory.doabooks.org/handle/20.500.12854/87508 eng application/octet-stream Attribution 4.0 International https://mdpi.com/books/pdfview/book/5706 https://mdpi.com/books/pdfview/book/5706 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-0365-4172-3 10.3390/books978-3-0365-4172-3 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783036541716 9783036541723 318 Basel open access |
| spellingShingle | Trace elements hair children hazardous waste incinerator Constantí (Catalonia, Spain) blood lead level boatyard childhood lead poisoning fishing community lead weights β2-microglobulin cadmium creatinine clearance glomerular filtration N-acetyl-β-d-glucosaminidase nephron mass nephrotoxicity trace elements autopsy tissues temporal trends creatinine excretion glomerular filtration rate lead kidney endocytosis metallothionein flow cytometry proximal tubule epithelial cells OGTT minimal model glucose response mechanism genotoxicity aluminum chloride rats food farmer PTWI (provisional tolerable monthly intake) TWI (tolerable weekly intake) Monte Carlo simulation mercury obesogen lipid profiles hyperlipidemia elevated liver enzymes hexavalent chromium [Cr(VI)] mitochondrial fragmentation dynamin-related protein 1 (Drp1) mitochondrial respiratory chain complex I (MRCC I) reactive oxygen species (ROS) blood lead cellular immunity phagocytosis humoral munity immunosuppression insulin diabetes hyperglycemia hyperinsulinemia lipogenic β-cell toxicity stroke cerebrovascular accident heavy metal rare earth element case-control study mortality lifetime cadmium intake renal diseases urinary cadmium a follow-up study diet kidney function chronic kidney disease threshold limit tolerable intake level heavy metals birth weight preterm birth diet pattern Mediterranean diet pregnancy toxic metals reproduction testicular and ovarian structure n/a thema EDItEUR::M Medicine and Nursing::MB Medicine: general issues::MBN Public health and preventive medicine Toxic Metals, Chronic Diseases and Related Cancers |
| title | Toxic Metals, Chronic Diseases and Related Cancers |
| title_full | Toxic Metals, Chronic Diseases and Related Cancers |
| title_fullStr | Toxic Metals, Chronic Diseases and Related Cancers |
| title_full_unstemmed | Toxic Metals, Chronic Diseases and Related Cancers |
| title_short | Toxic Metals, Chronic Diseases and Related Cancers |
| title_sort | toxic metals chronic diseases and related cancers |
| topic | Trace elements hair children hazardous waste incinerator Constantí (Catalonia, Spain) blood lead level boatyard childhood lead poisoning fishing community lead weights β2-microglobulin cadmium creatinine clearance glomerular filtration N-acetyl-β-d-glucosaminidase nephron mass nephrotoxicity trace elements autopsy tissues temporal trends creatinine excretion glomerular filtration rate lead kidney endocytosis metallothionein flow cytometry proximal tubule epithelial cells OGTT minimal model glucose response mechanism genotoxicity aluminum chloride rats food farmer PTWI (provisional tolerable monthly intake) TWI (tolerable weekly intake) Monte Carlo simulation mercury obesogen lipid profiles hyperlipidemia elevated liver enzymes hexavalent chromium [Cr(VI)] mitochondrial fragmentation dynamin-related protein 1 (Drp1) mitochondrial respiratory chain complex I (MRCC I) reactive oxygen species (ROS) blood lead cellular immunity phagocytosis humoral munity immunosuppression insulin diabetes hyperglycemia hyperinsulinemia lipogenic β-cell toxicity stroke cerebrovascular accident heavy metal rare earth element case-control study mortality lifetime cadmium intake renal diseases urinary cadmium a follow-up study diet kidney function chronic kidney disease threshold limit tolerable intake level heavy metals birth weight preterm birth diet pattern Mediterranean diet pregnancy toxic metals reproduction testicular and ovarian structure n/a thema EDItEUR::M Medicine and Nursing::MB Medicine: general issues::MBN Public health and preventive medicine |
| topic_facet | Trace elements hair children hazardous waste incinerator Constantí (Catalonia, Spain) blood lead level boatyard childhood lead poisoning fishing community lead weights β2-microglobulin cadmium creatinine clearance glomerular filtration N-acetyl-β-d-glucosaminidase nephron mass nephrotoxicity trace elements autopsy tissues temporal trends creatinine excretion glomerular filtration rate lead kidney endocytosis metallothionein flow cytometry proximal tubule epithelial cells OGTT minimal model glucose response mechanism genotoxicity aluminum chloride rats food farmer PTWI (provisional tolerable monthly intake) TWI (tolerable weekly intake) Monte Carlo simulation mercury obesogen lipid profiles hyperlipidemia elevated liver enzymes hexavalent chromium [Cr(VI)] mitochondrial fragmentation dynamin-related protein 1 (Drp1) mitochondrial respiratory chain complex I (MRCC I) reactive oxygen species (ROS) blood lead cellular immunity phagocytosis humoral munity immunosuppression insulin diabetes hyperglycemia hyperinsulinemia lipogenic β-cell toxicity stroke cerebrovascular accident heavy metal rare earth element case-control study mortality lifetime cadmium intake renal diseases urinary cadmium a follow-up study diet kidney function chronic kidney disease threshold limit tolerable intake level heavy metals birth weight preterm birth diet pattern Mediterranean diet pregnancy toxic metals reproduction testicular and ovarian structure n/a thema EDItEUR::M Medicine and Nursing::MB Medicine: general issues::MBN Public health and preventive medicine |
| url | ONIX_20220706_9783036541716_103 |