Oncologic Thermoradiotherapy: Need for Evidence, Harmonisation, and Innovation

The road of acceptance of oncologic thermotherapy/hyperthermia as a synergistic modality in combination with standard oncologic therapies is still bumpy. This is partially due to the lack of level I evidence from international, multicentric, randomized clinical trials including large patient numbers...

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collection Directory of Open Access Books
description The road of acceptance of oncologic thermotherapy/hyperthermia as a synergistic modality in combination with standard oncologic therapies is still bumpy. This is partially due to the lack of level I evidence from international, multicentric, randomized clinical trials including large patient numbers and a long term follow-up. Therefore we need more level I EVIDENCE from clinical trials, we need HARMONISATION and global acceptance for existing technologies and a common language understood by all stakeholders and we need INNOVATION in the fields of biology, clinics and technology to move thermotherapy/hyperthermia forward. This is the main focus of this reprint. In this reprintyou find carefully selected and peer-reviewed contributions from Africa, America, Asia, and Europe. The published papers from leading scientists from all over the world covering a broad range of timely research topics might also help to strengthen thermotherapy on a global level.
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institution Directory of Open Access Books
language eng
publishDate 2022
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publisher MDPI - Multidisciplinary Digital Publishing Institute
publisherStr MDPI - Multidisciplinary Digital Publishing Institute
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spelling doab-20.500.12854ir-875162024-03-31T13:10:39Z Oncologic Thermoradiotherapy: Need for Evidence, Harmonisation, and Innovation Bodis, Stephan Ghadjar, Pirus Van Rhoon, Gerard C. perfusion estimation temperature monitoring conductivity reconstruction systems medicine immune system in silico perceptron antigen pattern danger signal fractionation immune response head and neck cancer hyperthermia reirradiation treatment outcome hyperthermia treatment planning adaptive planning temperature optimization low-middle-income group countries cancer radiotherapy chemotherapy recurrent breast cancers cervical cancer head and neck cancers cost-effective meta-analysis intensity-modulated radiotherapy prostate cancer thermal dose thermometric parameters preclinical data clinical evidence modulated electro-hyperthermia abscopal effect locally advanced cervical cancer resource-constrained setting radiosensitiser rectal cancer chemoradiotherapy tumour control loco-regional hyperthermia oncology cellular selection bioelectromagnetics complexity immune-effects moderate hyperthermia deep hyperthermia radiative hyperthermia patterns of care reimbursement regional hyperthermia neoadjuvant chemoradiation survival induced brachytherapy prostatic neoplasms interstitial hyperthermia treatment plan optimization prostate thermoradiotherapy linear quadratic model biological modeling thermal dosimetry hypoxia radiation therapy reoxygenation perfusion oxygen consumption rate local tumor control biomarker immune phenotype hyperthermia treatment sequence breast cancer immune checkpoint molecules dendritic cell activation n/a thema EDItEUR::M Medicine and Nursing thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCL Oncology The road of acceptance of oncologic thermotherapy/hyperthermia as a synergistic modality in combination with standard oncologic therapies is still bumpy. This is partially due to the lack of level I evidence from international, multicentric, randomized clinical trials including large patient numbers and a long term follow-up. Therefore we need more level I EVIDENCE from clinical trials, we need HARMONISATION and global acceptance for existing technologies and a common language understood by all stakeholders and we need INNOVATION in the fields of biology, clinics and technology to move thermotherapy/hyperthermia forward. This is the main focus of this reprint. In this reprintyou find carefully selected and peer-reviewed contributions from Africa, America, Asia, and Europe. The published papers from leading scientists from all over the world covering a broad range of timely research topics might also help to strengthen thermotherapy on a global level. 2022-07-06T11:54:01Z 2022-07-06T11:54:01Z 2022 book ONIX_20220706_9783036545325_111 9783036545325 9783036545318 https://directory.doabooks.org/handle/20.500.12854/87516 eng application/octet-stream Attribution 4.0 International https://mdpi.com/books/pdfview/book/5714 https://mdpi.com/books/pdfview/book/5714 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-0365-4531-8 10.3390/books978-3-0365-4531-8 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783036545325 9783036545318 346 Basel open access
spellingShingle perfusion estimation
temperature monitoring
conductivity reconstruction
systems medicine
immune system in silico
perceptron
antigen pattern
danger signal
fractionation
immune response
head and neck cancer
hyperthermia
reirradiation
treatment outcome
hyperthermia treatment planning
adaptive planning
temperature optimization
low-middle-income group countries
cancer
radiotherapy
chemotherapy
recurrent breast cancers
cervical cancer
head and neck cancers
cost-effective
meta-analysis
intensity-modulated radiotherapy
prostate cancer
thermal dose
thermometric parameters
preclinical data
clinical evidence
modulated electro-hyperthermia
abscopal effect
locally advanced cervical cancer
resource-constrained setting
radiosensitiser
rectal cancer
chemoradiotherapy
tumour control
loco-regional hyperthermia
oncology
cellular selection
bioelectromagnetics
complexity
immune-effects
moderate hyperthermia
deep hyperthermia
radiative hyperthermia
patterns of care
reimbursement
regional hyperthermia
neoadjuvant chemoradiation
survival
induced
brachytherapy
prostatic neoplasms
interstitial hyperthermia
treatment plan optimization
prostate
thermoradiotherapy
linear quadratic model
biological modeling
thermal dosimetry
hypoxia
radiation therapy
reoxygenation
perfusion
oxygen consumption rate
local tumor control
biomarker
immune phenotype
hyperthermia treatment sequence
breast cancer
immune checkpoint molecules
dendritic cell activation
n/a
thema EDItEUR::M Medicine and Nursing
thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCL Oncology
Oncologic Thermoradiotherapy: Need for Evidence, Harmonisation, and Innovation
title Oncologic Thermoradiotherapy: Need for Evidence, Harmonisation, and Innovation
title_full Oncologic Thermoradiotherapy: Need for Evidence, Harmonisation, and Innovation
title_fullStr Oncologic Thermoradiotherapy: Need for Evidence, Harmonisation, and Innovation
title_full_unstemmed Oncologic Thermoradiotherapy: Need for Evidence, Harmonisation, and Innovation
title_short Oncologic Thermoradiotherapy: Need for Evidence, Harmonisation, and Innovation
title_sort oncologic thermoradiotherapy need for evidence harmonisation and innovation
topic perfusion estimation
temperature monitoring
conductivity reconstruction
systems medicine
immune system in silico
perceptron
antigen pattern
danger signal
fractionation
immune response
head and neck cancer
hyperthermia
reirradiation
treatment outcome
hyperthermia treatment planning
adaptive planning
temperature optimization
low-middle-income group countries
cancer
radiotherapy
chemotherapy
recurrent breast cancers
cervical cancer
head and neck cancers
cost-effective
meta-analysis
intensity-modulated radiotherapy
prostate cancer
thermal dose
thermometric parameters
preclinical data
clinical evidence
modulated electro-hyperthermia
abscopal effect
locally advanced cervical cancer
resource-constrained setting
radiosensitiser
rectal cancer
chemoradiotherapy
tumour control
loco-regional hyperthermia
oncology
cellular selection
bioelectromagnetics
complexity
immune-effects
moderate hyperthermia
deep hyperthermia
radiative hyperthermia
patterns of care
reimbursement
regional hyperthermia
neoadjuvant chemoradiation
survival
induced
brachytherapy
prostatic neoplasms
interstitial hyperthermia
treatment plan optimization
prostate
thermoradiotherapy
linear quadratic model
biological modeling
thermal dosimetry
hypoxia
radiation therapy
reoxygenation
perfusion
oxygen consumption rate
local tumor control
biomarker
immune phenotype
hyperthermia treatment sequence
breast cancer
immune checkpoint molecules
dendritic cell activation
n/a
thema EDItEUR::M Medicine and Nursing
thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCL Oncology
topic_facet perfusion estimation
temperature monitoring
conductivity reconstruction
systems medicine
immune system in silico
perceptron
antigen pattern
danger signal
fractionation
immune response
head and neck cancer
hyperthermia
reirradiation
treatment outcome
hyperthermia treatment planning
adaptive planning
temperature optimization
low-middle-income group countries
cancer
radiotherapy
chemotherapy
recurrent breast cancers
cervical cancer
head and neck cancers
cost-effective
meta-analysis
intensity-modulated radiotherapy
prostate cancer
thermal dose
thermometric parameters
preclinical data
clinical evidence
modulated electro-hyperthermia
abscopal effect
locally advanced cervical cancer
resource-constrained setting
radiosensitiser
rectal cancer
chemoradiotherapy
tumour control
loco-regional hyperthermia
oncology
cellular selection
bioelectromagnetics
complexity
immune-effects
moderate hyperthermia
deep hyperthermia
radiative hyperthermia
patterns of care
reimbursement
regional hyperthermia
neoadjuvant chemoradiation
survival
induced
brachytherapy
prostatic neoplasms
interstitial hyperthermia
treatment plan optimization
prostate
thermoradiotherapy
linear quadratic model
biological modeling
thermal dosimetry
hypoxia
radiation therapy
reoxygenation
perfusion
oxygen consumption rate
local tumor control
biomarker
immune phenotype
hyperthermia treatment sequence
breast cancer
immune checkpoint molecules
dendritic cell activation
n/a
thema EDItEUR::M Medicine and Nursing
thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCL Oncology
url ONIX_20220706_9783036545325_111