Colorectal Cancers: From Present Problems to Future Solutions
The scientific community has made significant progress in our molecular understanding of sporadic and hereditary colorectal carcinogenesis and progression. Thie pertains to, e.g., the discovery of (mutated) oncogenes and tumor suppressor genes, microsatellite instabilities, modifications in DNA repa...
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| Aineistotyyppi: | Online |
|---|---|
| Kieli: | englanti |
| Julkaistu: |
MDPI - Multidisciplinary Digital Publishing Institute
2022
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| Aiheet: | |
| Linkit: | ONIX_20220812_9783036547275_34 |
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| _version_ | 1869531625667166208 |
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| collection | Directory of Open Access Books |
| description | The scientific community has made significant progress in our molecular understanding of sporadic and hereditary colorectal carcinogenesis and progression. Thie pertains to, e.g., the discovery of (mutated) oncogenes and tumor suppressor genes, microsatellite instabilities, modifications in DNA repair, cellular aging, signaling cascades, genomic, epigenetic, transcriptional, translational, and protein modifications, as well as microbiotic factors and further parameters. Progression and metastasis have been more intensively studied, especially during recent years, leading to an intensified knowledge on molecular protagonists and microenvironmental interactions contributing to invasion, dissemination, and metastasis; still, more concerted efforts need to be made to better understand issues such as metastasis to different sites or the metastatic heterogeneity of single cells. Nevertheless, based on actual discoveries, personalized medicine, together with highly interdisciplinary therapeutic strategies combining advanced levels of surgical techniques, oncology, and radiation in neoadjuvant, adjuvant, or palliative settings, has started to improve the clinical prognosis of individual patients with colorectal cancer. The present Special Issue features articles of excellent international experts with the latest data in the fields mentioned. With this Special Issue, we aim to deepen discussions amongst colleagues in all kinds of disciplines working on this disease and to intensify interdisciplinary collaborations aimed at an ultimate understanding of strategies to defeat and prevent, colorectal cancer, and its progression. |
| format | Online |
| id | doab-20.500.12854ir-91155 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2022 |
| publishDateRange | 2022 |
| publishDateSort | 2022 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-911552024-03-31T13:10:47Z Colorectal Cancers: From Present Problems to Future Solutions Allgayer, Heike Phage bacteriophages diet infection colorectal cancer nutrition circulating tumor cells colorectal cancer EPISPOT assay CellSearch® system predictive value chromatin density nanoscale tumour cell heterogeneity microRNAs metastasis super-resolution microscopy early onset cohort epidemiology liquid biopsy biomarker indirect carcinogenesis bovine meat and milk factors (BMMF) chronic zoonosis multiplex tumor immunology immune landscape spontaneous feline intestinal tumors comparative oncology tumor budding CTNNB1 genome-wide methylation array methylation miRNA colon cancer personalized treatment drug combinations Matrix Metalloproteinases (MMPs) polyp TIMPs MMP polymorphisms MMP targeting S100A4 DKK1 Wnt signaling patient survival gender rectal cancer radiochemotherapy radiosensitivity DNA double-strand breaks deposited energy quality of life blood values (molecular) carcinogenesis cancer progression (single) cancer cell heterogeneity models infectious agents (targeted) therapy personalized medicine thema EDItEUR::M Medicine and Nursing thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCL Oncology The scientific community has made significant progress in our molecular understanding of sporadic and hereditary colorectal carcinogenesis and progression. Thie pertains to, e.g., the discovery of (mutated) oncogenes and tumor suppressor genes, microsatellite instabilities, modifications in DNA repair, cellular aging, signaling cascades, genomic, epigenetic, transcriptional, translational, and protein modifications, as well as microbiotic factors and further parameters. Progression and metastasis have been more intensively studied, especially during recent years, leading to an intensified knowledge on molecular protagonists and microenvironmental interactions contributing to invasion, dissemination, and metastasis; still, more concerted efforts need to be made to better understand issues such as metastasis to different sites or the metastatic heterogeneity of single cells. Nevertheless, based on actual discoveries, personalized medicine, together with highly interdisciplinary therapeutic strategies combining advanced levels of surgical techniques, oncology, and radiation in neoadjuvant, adjuvant, or palliative settings, has started to improve the clinical prognosis of individual patients with colorectal cancer. The present Special Issue features articles of excellent international experts with the latest data in the fields mentioned. With this Special Issue, we aim to deepen discussions amongst colleagues in all kinds of disciplines working on this disease and to intensify interdisciplinary collaborations aimed at an ultimate understanding of strategies to defeat and prevent, colorectal cancer, and its progression. 2022-08-12T12:45:50Z 2022-08-12T12:45:50Z 2022 book ONIX_20220812_9783036547275_34 9783036547275 9783036547282 https://directory.doabooks.org/handle/20.500.12854/91155 eng image/jpeg Attribution 4.0 International https://mdpi.com/books/pdfview/book/5800 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-0365-4728-2 10.3390/books978-3-0365-4728-2 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783036547275 9783036547282 238 Basel open access |
| spellingShingle | Phage bacteriophages diet infection colorectal cancer nutrition circulating tumor cells colorectal cancer EPISPOT assay CellSearch® system predictive value chromatin density nanoscale tumour cell heterogeneity microRNAs metastasis super-resolution microscopy early onset cohort epidemiology liquid biopsy biomarker indirect carcinogenesis bovine meat and milk factors (BMMF) chronic zoonosis multiplex tumor immunology immune landscape spontaneous feline intestinal tumors comparative oncology tumor budding CTNNB1 genome-wide methylation array methylation miRNA colon cancer personalized treatment drug combinations Matrix Metalloproteinases (MMPs) polyp TIMPs MMP polymorphisms MMP targeting S100A4 DKK1 Wnt signaling patient survival gender rectal cancer radiochemotherapy radiosensitivity DNA double-strand breaks deposited energy quality of life blood values (molecular) carcinogenesis cancer progression (single) cancer cell heterogeneity models infectious agents (targeted) therapy personalized medicine thema EDItEUR::M Medicine and Nursing thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCL Oncology Colorectal Cancers: From Present Problems to Future Solutions |
| title | Colorectal Cancers: From Present Problems to Future Solutions |
| title_full | Colorectal Cancers: From Present Problems to Future Solutions |
| title_fullStr | Colorectal Cancers: From Present Problems to Future Solutions |
| title_full_unstemmed | Colorectal Cancers: From Present Problems to Future Solutions |
| title_short | Colorectal Cancers: From Present Problems to Future Solutions |
| title_sort | colorectal cancers from present problems to future solutions |
| topic | Phage bacteriophages diet infection colorectal cancer nutrition circulating tumor cells colorectal cancer EPISPOT assay CellSearch® system predictive value chromatin density nanoscale tumour cell heterogeneity microRNAs metastasis super-resolution microscopy early onset cohort epidemiology liquid biopsy biomarker indirect carcinogenesis bovine meat and milk factors (BMMF) chronic zoonosis multiplex tumor immunology immune landscape spontaneous feline intestinal tumors comparative oncology tumor budding CTNNB1 genome-wide methylation array methylation miRNA colon cancer personalized treatment drug combinations Matrix Metalloproteinases (MMPs) polyp TIMPs MMP polymorphisms MMP targeting S100A4 DKK1 Wnt signaling patient survival gender rectal cancer radiochemotherapy radiosensitivity DNA double-strand breaks deposited energy quality of life blood values (molecular) carcinogenesis cancer progression (single) cancer cell heterogeneity models infectious agents (targeted) therapy personalized medicine thema EDItEUR::M Medicine and Nursing thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCL Oncology |
| topic_facet | Phage bacteriophages diet infection colorectal cancer nutrition circulating tumor cells colorectal cancer EPISPOT assay CellSearch® system predictive value chromatin density nanoscale tumour cell heterogeneity microRNAs metastasis super-resolution microscopy early onset cohort epidemiology liquid biopsy biomarker indirect carcinogenesis bovine meat and milk factors (BMMF) chronic zoonosis multiplex tumor immunology immune landscape spontaneous feline intestinal tumors comparative oncology tumor budding CTNNB1 genome-wide methylation array methylation miRNA colon cancer personalized treatment drug combinations Matrix Metalloproteinases (MMPs) polyp TIMPs MMP polymorphisms MMP targeting S100A4 DKK1 Wnt signaling patient survival gender rectal cancer radiochemotherapy radiosensitivity DNA double-strand breaks deposited energy quality of life blood values (molecular) carcinogenesis cancer progression (single) cancer cell heterogeneity models infectious agents (targeted) therapy personalized medicine thema EDItEUR::M Medicine and Nursing thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCL Oncology |
| url | ONIX_20220812_9783036547275_34 |