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Impaired Mitochondrial Bioenergetics under Pathological Conditions

Mitochondria are the powerhouses of cells; however, mitochondrial dysfunction causes energy depletion and cell death in a variety of diseases. Altered oxidative phosphorylation and ion homeostasis are associated with ROS production resulting from the disassembly of respiratory supercomplexes and the...

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Salvato in:
Natura: Online
Lingua:inglese
Pubblicazione: MDPI - Multidisciplinary Digital Publishing Institute 2022
Soggetti:
aging heart
Bcl-2 family
mitochondria
programmed cell death
fatty acid oxidation
palmitate
oleate
m.3243A&gt
G mutation
MT-ATP6
m.8909T&gt
C
ATP synthase
nephropathy
oxidative phosphorylation
mitochondrial disease
cardiolipin
Barth syndrome
Sengers syndrome
respiratory chain
Dilated Cardiomyopathy with Ataxia
cardiomyopathy
mammalian complex I
NADH dehydrogenase
complex I assembly
complex I structure
complex I deficiency
supernumerary subunits
electron transport chain
mitochondrial dysfunction
Leigh syndrome
mitochondrial diseases
yeast
Saccharomyces cerevisiae
pet mutants
pancreatic endocrine cells
mathematical model
cellular bioenergetics
diabetes
glucagon
insulin
exercise
immune system
metabolic disease
COVID-19
mitochondrial dynamics
viral infections
MAVS
RIG-I
MDA5
innate immune response
SARS CoV-2
RSV
influenza
respiratory supercomplexes
ROS
ATP synthase/hydrolase
mitochondrial permeability transition pore
cristae
cellular signaling
human disease
mitochondrial dynamic
cell signaling
cancer
respiratory complexes
oxidative stress
mitochondrial DNA
MTCYB mutations
cytochrome b
complex III
aging
energy metabolism
entorhinal cortex
lipoxidation-derived damage
neurodegeneration
oxidative damage
protein import
respiratory complex assembly
supercomplexes
mitochondrial proteostasis
heart failure
bioenergetics
assembly factor
atypical myopathy
high-resolution respirometry
toxicity assays
cell culture
equine primary myoblasts
fibroblasts
frozen tissue
leukocytes
oxygen consumption
platelets
respirometry
skeletal muscle
n/a
thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general
thema EDItEUR::P Mathematics and Science::PS Biology, life sciences
thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSB Biochemistry
Accesso online:ONIX_20220812_9783036546483_62
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