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Theme Issue Honoring Prof. Dr. Ludger Wessjohann’s 60th Birthday: Natural Products in Modern Drug Discovery

Nature continuously produces biologically useful molecules and provides humankind with life-saving drugs or therapies. Natural products (NPs) offer a vast, unique and fascinating chemical diversity and these molecules have evolved for optimal interactions with biological macromolecules. Moreover, na...

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Salvato in:
Natura: Online
Lingua:inglese
Pubblicazione: MDPI - Multidisciplinary Digital Publishing Institute 2022
Soggetti:
multi-component reaction
fusidic acid
TEMPO-conjugate
electron paramagnetic resonance (EPR) spectroscopy
caspase-3
incomptine A
sesquiterpene lactone
Decachaeta incompta
cytotoxic activity
iTRAQ
apoptosis
ROS production
violacein
hepatocellular carcinoma
proliferation
stemness
natural products
tumor microenvironment (TME)
lung cancer
phytochemicals
botanical agents
steroidal alkaloids
solanidane alkaloids
demissidine
solanidine
flavonoids
coronavirus
SARS-CoV-2
SARS-CoV
MERS-CoV
anticancer activity
apoptosis resistance
ophiobolin A
polygodial
Wittig reaction
melanoma
tumor heterogeneity
pregnancy
anti-tumor peptides
in vitro model
medicinal herbs
cancer treatment
cancer stem cells
drug resistance
metastasis
RCE-4
PCD
ATG 4B
the Bcl-2–Beclin 1 complex
Sparticola junci
structure elucidation
ECD-TDDFT
COX inhibitory
molecular docking
antiproliferative
cytotoxic
Sepedonium ampullosporum
peptaibols
ampullosporin
glutamic acid methyl ester
solid-phase peptide synthesis
antifungal
anticancer
target identification
kaempferol
docking
DARTS
Src
breast cancer
butein
frondoside-A
STAT3
angiogenesis
invasion
viability
tumor growth
marine fungi
Cosmospora sp.
soudanone
Magnaporthe oryzae
co-culture
phytopathogen
molecular networking
metabolomics
bispecific antibody
Trypsiligase
click chemistry
biorthogonal chemistry
antibody engineering
n/a
thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general
thema EDItEUR::P Mathematics and Science::PN Chemistry
thema EDItEUR::P Mathematics and Science::PN Chemistry::PNN Organic chemistry
Accesso online:ONIX_20220812_9783036547442_113
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Riassunto:Nature continuously produces biologically useful molecules and provides humankind with life-saving drugs or therapies. Natural products (NPs) offer a vast, unique and fascinating chemical diversity and these molecules have evolved for optimal interactions with biological macromolecules. Moreover, natural products feature pharmacologically active pharmacophores which are pharmaceutically validated starting points for the development of new lead compounds. Over half of all approved (from 1981 to 2014) small-molecule drugs derived from NPs, including unaltered NPs, NPs synthetic derivatives and synthetic natural mimics, originated from a NPs pharmacophore or template. According to the FDA, NPs and their derivatives represent over one-third of all FDA-approved new drugs, in particular for anticancer/antibiotic lead compounds, which are remarkably enriched with NPs.

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