Model Systems in Biology
How biomedical research using various animal species and in vitro cellular systems has resulted in both major successes and translational failure. In Model Systems in Biology, comparative neurobiologist Georg Striedter examines how biomedical researchers have used animal species and in vitro cell...
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| Format: | Online |
| Langue: | anglais |
| Publié: |
The MIT Press
2022
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| Accès en ligne: | https://directory.doabooks.org/handle/20.500.12854/91422 |
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| _version_ | 1869523999193563136 |
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| author | Striedter, Georg |
| author_browse | Striedter, Georg |
| author_facet | Striedter, Georg |
| author_sort | Striedter, Georg |
| collection | Directory of Open Access Books |
| description | How biomedical research using various animal species and in vitro cellular systems has resulted in both major successes and translational failure.
In Model Systems in Biology, comparative neurobiologist Georg Striedter examines how biomedical researchers have used animal species and in vitro cellular systems to understand and develop treatments for human diseases ranging from cancer and polio to Alzheimer's disease and schizophrenia. Although there have been some major successes, much of this “translational” research on model systems has failed to generalize to humans. Striedter explores the history of such research, focusing on the models used and considering the question of model selection from a variety of perspectives—the philosophical, the historical, and that of practicing biologists.
Striedter reviews some philosophical concepts and ethical issues, including concerns over animal suffering and the compromises that result. He traces the history of the most widely used animal and in vitro models, describing how they compete with one another in a changing ecosystem of models. He examines how therapies for bacterial and viral infections, cancer, cardiovascular diseases, and neurological disorders have been developed using animal and cell culture models—and how research into these diseases has both taken advantage of and been hindered by model system differences. Finally, Striedter argues for a “big tent” biology, in which a diverse set of models and research strategies can coexist productively. |
| format | Online |
| id | doab-20.500.12854ir-91422 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2022 |
| publishDateRange | 2022 |
| publishDateSort | 2022 |
| publisher | The MIT Press |
| publisherStr | The MIT Press |
| record_format | ojs |
| spelling | doab-20.500.12854ir-914222024-04-09T11:40:26Z Model Systems in Biology Striedter, Georg Animal Models;Model Species;Model Systems;Non-human;In Vitro;Comparative Medicine;Comparative Animals;Biology;Replicability;Laboratory Animals;Animal Welfare. thema EDItEUR::R Earth Sciences, Geography, Environment, Planning::RG Geography::RGM Biogeography thema EDItEUR::M Medicine and Nursing::MQ Nursing and ancillary services::MQW Biomedical engineering thema EDItEUR::P Mathematics and Science::PD Science: general issues::PDG Industrial applications of scientific research and technological innovation How biomedical research using various animal species and in vitro cellular systems has resulted in both major successes and translational failure. In Model Systems in Biology, comparative neurobiologist Georg Striedter examines how biomedical researchers have used animal species and in vitro cellular systems to understand and develop treatments for human diseases ranging from cancer and polio to Alzheimer's disease and schizophrenia. Although there have been some major successes, much of this “translational” research on model systems has failed to generalize to humans. Striedter explores the history of such research, focusing on the models used and considering the question of model selection from a variety of perspectives—the philosophical, the historical, and that of practicing biologists. Striedter reviews some philosophical concepts and ethical issues, including concerns over animal suffering and the compromises that result. He traces the history of the most widely used animal and in vitro models, describing how they compete with one another in a changing ecosystem of models. He examines how therapies for bacterial and viral infections, cancer, cardiovascular diseases, and neurological disorders have been developed using animal and cell culture models—and how research into these diseases has both taken advantage of and been hindered by model system differences. Finally, Striedter argues for a “big tent” biology, in which a diverse set of models and research strategies can coexist productively. 2022-08-23T08:44:48Z 2022-08-23T08:44:48Z 2022 book 9780262046947 https://directory.doabooks.org/handle/20.500.12854/91422 eng The MIT Press image/jpeg Attribution-NonCommercial-NoDerivatives 4.0 International https://doi.org/10.7551/mitpress/14366.001.0001 https://doi.org/10.7551/mitpress/14366.001.0001 The MIT Press 10.7551/mitpress/14366.001.0001 10.7551/mitpress/14366.001.0001 ae0cf962-f685-4933-93d1-916defa5123d 9780262046947 304 Cambridge open access |
| spellingShingle | Animal Models;Model Species;Model Systems;Non-human;In Vitro;Comparative Medicine;Comparative Animals;Biology;Replicability;Laboratory Animals;Animal Welfare. thema EDItEUR::R Earth Sciences, Geography, Environment, Planning::RG Geography::RGM Biogeography thema EDItEUR::M Medicine and Nursing::MQ Nursing and ancillary services::MQW Biomedical engineering thema EDItEUR::P Mathematics and Science::PD Science: general issues::PDG Industrial applications of scientific research and technological innovation Striedter, Georg Model Systems in Biology |
| title | Model Systems in Biology |
| title_full | Model Systems in Biology |
| title_fullStr | Model Systems in Biology |
| title_full_unstemmed | Model Systems in Biology |
| title_short | Model Systems in Biology |
| title_sort | model systems in biology |
| topic | Animal Models;Model Species;Model Systems;Non-human;In Vitro;Comparative Medicine;Comparative Animals;Biology;Replicability;Laboratory Animals;Animal Welfare. thema EDItEUR::R Earth Sciences, Geography, Environment, Planning::RG Geography::RGM Biogeography thema EDItEUR::M Medicine and Nursing::MQ Nursing and ancillary services::MQW Biomedical engineering thema EDItEUR::P Mathematics and Science::PD Science: general issues::PDG Industrial applications of scientific research and technological innovation |
| topic_facet | Animal Models;Model Species;Model Systems;Non-human;In Vitro;Comparative Medicine;Comparative Animals;Biology;Replicability;Laboratory Animals;Animal Welfare. thema EDItEUR::R Earth Sciences, Geography, Environment, Planning::RG Geography::RGM Biogeography thema EDItEUR::M Medicine and Nursing::MQ Nursing and ancillary services::MQW Biomedical engineering thema EDItEUR::P Mathematics and Science::PD Science: general issues::PDG Industrial applications of scientific research and technological innovation |
| url | https://directory.doabooks.org/handle/20.500.12854/91422 |
| work_keys_str_mv | AT striedtergeorg modelsystemsinbiology |