Enhancing Mesenchymal Stem Cells (MSCs) for Therapeutic Purposes
The regenerative and immunomodulatory properties of mesenchymal stem cells (MSCs) have made these cells the focus of multiple pre-clinical studies and clinical trials. While the results from these clinical studies have established that MSCs are safe, the efficacy of these cells is not as well-establ...
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| Format: | Online |
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| Sprog: | engelsk |
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2022
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| Online adgang: | ONIX_20220916_9783036549965_62 |
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| _version_ | 1869523533787299840 |
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| collection | Directory of Open Access Books |
| description | The regenerative and immunomodulatory properties of mesenchymal stem cells (MSCs) have made these cells the focus of multiple pre-clinical studies and clinical trials. While the results from these clinical studies have established that MSCs are safe, the efficacy of these cells is not as well-established. In this regard, there have been increased efforts towards generating potentiated/activated MSCs with enhanced therapeutic efficacy. Research on the mechanisms for enhancing MSC potency and efficacy is an area of active study with great potential for translation into clinical settings. The purpose of this book is to bring together recent research from a broad range of topics relating to potentiation strategies for enhancing MSC therapeutic efficacy, including growth factor pre-conditioning, hypoxia, and 3D culture. The research compiled in this book increases the basic understanding of MSC culture techniques and describes some MSC preparations for potential novel therapeutic applications. |
| format | Online |
| id | doab-20.500.12854ir-92076 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2022 |
| publishDateRange | 2022 |
| publishDateSort | 2022 |
| record_format | ojs |
| spelling | doab-20.500.12854ir-920762024-03-31T13:09:07Z Enhancing Mesenchymal Stem Cells (MSCs) for Therapeutic Purposes Ylostalo, Joni H. Durand, Nisha C. cell therapy immunomodulation polyunsaturated fatty acid CD206 phagocytosis mesenchymal stem cells Vadadustat AKB-6548 preconditioning priming secretome chemotaxis Wharton’s jelly mesenchymal stem cells umbilical cord oxygen conditions secretory profile neuroprotection mesenchymal stromal cells 3D culture neurospheres spheroids pluripotency neural quiescence mesothelioma malignant pleural mesothelioma (MPM) liver cirrhosis placenta-derived mesenchymal stem cells WKYMVm combination therapy iPSC-derived MSCs iMSC secretome pre-conditioning angiogenesis IFN-γ hypoxia potentiation of iMSC efficacy nanofiber-hydrogel composite spinal cord injury inflammation macrophages secondary injury astrocytes axon growth adipose tissue-derived stem cells (ASCs) autophagy rapamycin 3-methyladenine immunosuppression exosome engineered cardiac patches adipose-derived stem cell paracrine potential osteogenic differentiation hepatocyte growth factor fibroblast growth factor 2 thema EDItEUR::M Medicine and Nursing The regenerative and immunomodulatory properties of mesenchymal stem cells (MSCs) have made these cells the focus of multiple pre-clinical studies and clinical trials. While the results from these clinical studies have established that MSCs are safe, the efficacy of these cells is not as well-established. In this regard, there have been increased efforts towards generating potentiated/activated MSCs with enhanced therapeutic efficacy. Research on the mechanisms for enhancing MSC potency and efficacy is an area of active study with great potential for translation into clinical settings. The purpose of this book is to bring together recent research from a broad range of topics relating to potentiation strategies for enhancing MSC therapeutic efficacy, including growth factor pre-conditioning, hypoxia, and 3D culture. The research compiled in this book increases the basic understanding of MSC culture techniques and describes some MSC preparations for potential novel therapeutic applications. 2022-09-16T13:46:50Z 2022-09-16T13:46:50Z 2022 book ONIX_20220916_9783036549965_62 9783036549965 9783036549958 https://directory.doabooks.org/handle/20.500.12854/92076 eng application/octet-stream Attribution 4.0 International https://mdpi.com/books/pdfview/book/5952 https://mdpi.com/books/pdfview/book/5952 10.3390/books978-3-0365-4995-8 10.3390/books978-3-0365-4995-8 MDPI - Multidisciplinary Digital Publishing Institute 9783036549965 9783036549958 204 Basel open access |
| spellingShingle | cell therapy immunomodulation polyunsaturated fatty acid CD206 phagocytosis mesenchymal stem cells Vadadustat AKB-6548 preconditioning priming secretome chemotaxis Wharton’s jelly mesenchymal stem cells umbilical cord oxygen conditions secretory profile neuroprotection mesenchymal stromal cells 3D culture neurospheres spheroids pluripotency neural quiescence mesothelioma malignant pleural mesothelioma (MPM) liver cirrhosis placenta-derived mesenchymal stem cells WKYMVm combination therapy iPSC-derived MSCs iMSC secretome pre-conditioning angiogenesis IFN-γ hypoxia potentiation of iMSC efficacy nanofiber-hydrogel composite spinal cord injury inflammation macrophages secondary injury astrocytes axon growth adipose tissue-derived stem cells (ASCs) autophagy rapamycin 3-methyladenine immunosuppression exosome engineered cardiac patches adipose-derived stem cell paracrine potential osteogenic differentiation hepatocyte growth factor fibroblast growth factor 2 thema EDItEUR::M Medicine and Nursing Enhancing Mesenchymal Stem Cells (MSCs) for Therapeutic Purposes |
| title | Enhancing Mesenchymal Stem Cells (MSCs) for Therapeutic Purposes |
| title_full | Enhancing Mesenchymal Stem Cells (MSCs) for Therapeutic Purposes |
| title_fullStr | Enhancing Mesenchymal Stem Cells (MSCs) for Therapeutic Purposes |
| title_full_unstemmed | Enhancing Mesenchymal Stem Cells (MSCs) for Therapeutic Purposes |
| title_short | Enhancing Mesenchymal Stem Cells (MSCs) for Therapeutic Purposes |
| title_sort | enhancing mesenchymal stem cells mscs for therapeutic purposes |
| topic | cell therapy immunomodulation polyunsaturated fatty acid CD206 phagocytosis mesenchymal stem cells Vadadustat AKB-6548 preconditioning priming secretome chemotaxis Wharton’s jelly mesenchymal stem cells umbilical cord oxygen conditions secretory profile neuroprotection mesenchymal stromal cells 3D culture neurospheres spheroids pluripotency neural quiescence mesothelioma malignant pleural mesothelioma (MPM) liver cirrhosis placenta-derived mesenchymal stem cells WKYMVm combination therapy iPSC-derived MSCs iMSC secretome pre-conditioning angiogenesis IFN-γ hypoxia potentiation of iMSC efficacy nanofiber-hydrogel composite spinal cord injury inflammation macrophages secondary injury astrocytes axon growth adipose tissue-derived stem cells (ASCs) autophagy rapamycin 3-methyladenine immunosuppression exosome engineered cardiac patches adipose-derived stem cell paracrine potential osteogenic differentiation hepatocyte growth factor fibroblast growth factor 2 thema EDItEUR::M Medicine and Nursing |
| topic_facet | cell therapy immunomodulation polyunsaturated fatty acid CD206 phagocytosis mesenchymal stem cells Vadadustat AKB-6548 preconditioning priming secretome chemotaxis Wharton’s jelly mesenchymal stem cells umbilical cord oxygen conditions secretory profile neuroprotection mesenchymal stromal cells 3D culture neurospheres spheroids pluripotency neural quiescence mesothelioma malignant pleural mesothelioma (MPM) liver cirrhosis placenta-derived mesenchymal stem cells WKYMVm combination therapy iPSC-derived MSCs iMSC secretome pre-conditioning angiogenesis IFN-γ hypoxia potentiation of iMSC efficacy nanofiber-hydrogel composite spinal cord injury inflammation macrophages secondary injury astrocytes axon growth adipose tissue-derived stem cells (ASCs) autophagy rapamycin 3-methyladenine immunosuppression exosome engineered cardiac patches adipose-derived stem cell paracrine potential osteogenic differentiation hepatocyte growth factor fibroblast growth factor 2 thema EDItEUR::M Medicine and Nursing |
| url | ONIX_20220916_9783036549965_62 |