Recent Advances in the Synthesis, Functionalization and Applications of Pyrazole-Type Compounds I
Pyrazoles and their reduced form, pyrazolines, are considered privileged scaffolds in medicinal chemistry, owing to their noteworthy biological activities, physicochemical properties and occurrence in many low-molecular-weight compounds present in several marketed drugs (e.g., Celebrex® and Viagra®)...
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| Sprog: | engelsk |
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MDPI - Multidisciplinary Digital Publishing Institute
2022
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| Online adgang: | ONIX_20221117_9783036554211_6 |
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| description | Pyrazoles and their reduced form, pyrazolines, are considered privileged scaffolds in medicinal chemistry, owing to their noteworthy biological activities, physicochemical properties and occurrence in many low-molecular-weight compounds present in several marketed drugs (e.g., Celebrex® and Viagra®). Pyrazoles are also found in a variety of agrochemicals (fungicides, insecticides, and herbicides) and are versatile compounds for synthetic manipulations. Their challenging chemical structures and properties (mainly tautomerism, with possible implications in their reactivity), and diverse applications, have attracted the attention of many researchers who have developed various synthetic approaches. This reprint presents some examples of the most recent advances in pyrazoles’ chemistry, including synthetic methodologies to access novel pyrazole derivatives, to their functionalization, and studies of their properties and applications in different fields, mainly in medicine and materials science. |
| format | Online |
| id | doab-20.500.12854ir-93749 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2022 |
| publishDateRange | 2022 |
| publishDateSort | 2022 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-937492024-03-28T03:33:05Z Recent Advances in the Synthesis, Functionalization and Applications of Pyrazole-Type Compounds I Silva, Vera L. M. Silva, Artur M. S. pyrazolopyridopyridazine dione N-aminopyrazolopyrrolopyridine dione luminol photoluminescence pyrazole coumarin antimicrobial hydrazone biofilm Staphylococcus aureus S. epidermidis MRSA pyrazolyl-ureas pyrazole nucleus protein kinase inhibitors anti-inflammatory agents anticancer agents anti-pathogens agents nitrated pyrazoles-based energetic salts synthesis high energy density material insensitivity amination 4-halopyrazole Buchwald-Hartwig coupling Pd(dba)2 CuI mediated coupling aliphatic amine X-ray pyrazolate coinage metals metallacycles M06-2x pyrazolyl-s-triazine Fe(III) self-assembly Hirshfeld antimicrobial activity pyrazoles styrylpyrazoles biological activity organic synthesis reactivity homocoupling bipyrazole transition-metal catalysts metal–organic frameworks 1,3-dipolar cycloadditions 2,3-dihydropyrazolo[1,2-a]pyrazoles copper-catalyzed azomethine imine-alkyne cycloaddition (CuAIAC) azomethine imines ynones bis(pyrazol-1-yl)alkanes carboxylation oxalyl chloride dicarboxylic acids alkylation superbasic medium 1,2,4-oxadiazoles spiropyrazolinium compounds in vitro antitubercular screening X-ray diffraction molecular docking polynuclear silver crystal structure pyrazolate ligand coordination polymer functionalization heterocyclic neurodegeneration Alzheimer’s disease Parkinson’s disease inhibitor antagonist antitumor scaffold enzymatic inhibitory N-heterocyclic compounds pyrazolo[1,5-a]pyrimidine pyrazolo[1,5-a]pyrimidines aromatic substitution electrooxidation C–H halogenation C–H thiocyanation N–N coupling cyclic voltammetry n/a thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PN Chemistry thema EDItEUR::P Mathematics and Science::PN Chemistry::PNN Organic chemistry Pyrazoles and their reduced form, pyrazolines, are considered privileged scaffolds in medicinal chemistry, owing to their noteworthy biological activities, physicochemical properties and occurrence in many low-molecular-weight compounds present in several marketed drugs (e.g., Celebrex® and Viagra®). Pyrazoles are also found in a variety of agrochemicals (fungicides, insecticides, and herbicides) and are versatile compounds for synthetic manipulations. Their challenging chemical structures and properties (mainly tautomerism, with possible implications in their reactivity), and diverse applications, have attracted the attention of many researchers who have developed various synthetic approaches. This reprint presents some examples of the most recent advances in pyrazoles’ chemistry, including synthetic methodologies to access novel pyrazole derivatives, to their functionalization, and studies of their properties and applications in different fields, mainly in medicine and materials science. 2022-11-17T16:22:23Z 2022-11-17T16:22:23Z 2022 book ONIX_20221117_9783036554211_6 9783036554211 9783036554228 https://directory.doabooks.org/handle/20.500.12854/93749 eng image/jpeg Attribution 4.0 International https://mdpi.com/books/pdfview/book/6177 https://mdpi.com/books/pdfview/book/6177 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-0365-5421-1 10.3390/books978-3-0365-5421-1 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783036554211 9783036554228 400 Basel open access |
| spellingShingle | pyrazolopyridopyridazine dione N-aminopyrazolopyrrolopyridine dione luminol photoluminescence pyrazole coumarin antimicrobial hydrazone biofilm Staphylococcus aureus S. epidermidis MRSA pyrazolyl-ureas pyrazole nucleus protein kinase inhibitors anti-inflammatory agents anticancer agents anti-pathogens agents nitrated pyrazoles-based energetic salts synthesis high energy density material insensitivity amination 4-halopyrazole Buchwald-Hartwig coupling Pd(dba)2 CuI mediated coupling aliphatic amine X-ray pyrazolate coinage metals metallacycles M06-2x pyrazolyl-s-triazine Fe(III) self-assembly Hirshfeld antimicrobial activity pyrazoles styrylpyrazoles biological activity organic synthesis reactivity homocoupling bipyrazole transition-metal catalysts metal–organic frameworks 1,3-dipolar cycloadditions 2,3-dihydropyrazolo[1,2-a]pyrazoles copper-catalyzed azomethine imine-alkyne cycloaddition (CuAIAC) azomethine imines ynones bis(pyrazol-1-yl)alkanes carboxylation oxalyl chloride dicarboxylic acids alkylation superbasic medium 1,2,4-oxadiazoles spiropyrazolinium compounds in vitro antitubercular screening X-ray diffraction molecular docking polynuclear silver crystal structure pyrazolate ligand coordination polymer functionalization heterocyclic neurodegeneration Alzheimer’s disease Parkinson’s disease inhibitor antagonist antitumor scaffold enzymatic inhibitory N-heterocyclic compounds pyrazolo[1,5-a]pyrimidine pyrazolo[1,5-a]pyrimidines aromatic substitution electrooxidation C–H halogenation C–H thiocyanation N–N coupling cyclic voltammetry n/a thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PN Chemistry thema EDItEUR::P Mathematics and Science::PN Chemistry::PNN Organic chemistry Recent Advances in the Synthesis, Functionalization and Applications of Pyrazole-Type Compounds I |
| title | Recent Advances in the Synthesis, Functionalization and Applications of Pyrazole-Type Compounds I |
| title_full | Recent Advances in the Synthesis, Functionalization and Applications of Pyrazole-Type Compounds I |
| title_fullStr | Recent Advances in the Synthesis, Functionalization and Applications of Pyrazole-Type Compounds I |
| title_full_unstemmed | Recent Advances in the Synthesis, Functionalization and Applications of Pyrazole-Type Compounds I |
| title_short | Recent Advances in the Synthesis, Functionalization and Applications of Pyrazole-Type Compounds I |
| title_sort | recent advances in the synthesis functionalization and applications of pyrazole type compounds i |
| topic | pyrazolopyridopyridazine dione N-aminopyrazolopyrrolopyridine dione luminol photoluminescence pyrazole coumarin antimicrobial hydrazone biofilm Staphylococcus aureus S. epidermidis MRSA pyrazolyl-ureas pyrazole nucleus protein kinase inhibitors anti-inflammatory agents anticancer agents anti-pathogens agents nitrated pyrazoles-based energetic salts synthesis high energy density material insensitivity amination 4-halopyrazole Buchwald-Hartwig coupling Pd(dba)2 CuI mediated coupling aliphatic amine X-ray pyrazolate coinage metals metallacycles M06-2x pyrazolyl-s-triazine Fe(III) self-assembly Hirshfeld antimicrobial activity pyrazoles styrylpyrazoles biological activity organic synthesis reactivity homocoupling bipyrazole transition-metal catalysts metal–organic frameworks 1,3-dipolar cycloadditions 2,3-dihydropyrazolo[1,2-a]pyrazoles copper-catalyzed azomethine imine-alkyne cycloaddition (CuAIAC) azomethine imines ynones bis(pyrazol-1-yl)alkanes carboxylation oxalyl chloride dicarboxylic acids alkylation superbasic medium 1,2,4-oxadiazoles spiropyrazolinium compounds in vitro antitubercular screening X-ray diffraction molecular docking polynuclear silver crystal structure pyrazolate ligand coordination polymer functionalization heterocyclic neurodegeneration Alzheimer’s disease Parkinson’s disease inhibitor antagonist antitumor scaffold enzymatic inhibitory N-heterocyclic compounds pyrazolo[1,5-a]pyrimidine pyrazolo[1,5-a]pyrimidines aromatic substitution electrooxidation C–H halogenation C–H thiocyanation N–N coupling cyclic voltammetry n/a thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PN Chemistry thema EDItEUR::P Mathematics and Science::PN Chemistry::PNN Organic chemistry |
| topic_facet | pyrazolopyridopyridazine dione N-aminopyrazolopyrrolopyridine dione luminol photoluminescence pyrazole coumarin antimicrobial hydrazone biofilm Staphylococcus aureus S. epidermidis MRSA pyrazolyl-ureas pyrazole nucleus protein kinase inhibitors anti-inflammatory agents anticancer agents anti-pathogens agents nitrated pyrazoles-based energetic salts synthesis high energy density material insensitivity amination 4-halopyrazole Buchwald-Hartwig coupling Pd(dba)2 CuI mediated coupling aliphatic amine X-ray pyrazolate coinage metals metallacycles M06-2x pyrazolyl-s-triazine Fe(III) self-assembly Hirshfeld antimicrobial activity pyrazoles styrylpyrazoles biological activity organic synthesis reactivity homocoupling bipyrazole transition-metal catalysts metal–organic frameworks 1,3-dipolar cycloadditions 2,3-dihydropyrazolo[1,2-a]pyrazoles copper-catalyzed azomethine imine-alkyne cycloaddition (CuAIAC) azomethine imines ynones bis(pyrazol-1-yl)alkanes carboxylation oxalyl chloride dicarboxylic acids alkylation superbasic medium 1,2,4-oxadiazoles spiropyrazolinium compounds in vitro antitubercular screening X-ray diffraction molecular docking polynuclear silver crystal structure pyrazolate ligand coordination polymer functionalization heterocyclic neurodegeneration Alzheimer’s disease Parkinson’s disease inhibitor antagonist antitumor scaffold enzymatic inhibitory N-heterocyclic compounds pyrazolo[1,5-a]pyrimidine pyrazolo[1,5-a]pyrimidines aromatic substitution electrooxidation C–H halogenation C–H thiocyanation N–N coupling cyclic voltammetry n/a thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PN Chemistry thema EDItEUR::P Mathematics and Science::PN Chemistry::PNN Organic chemistry |
| url | ONIX_20221117_9783036554211_6 |