Clear Cell Renal Cell Carcinoma 2021–2022
Clear cell renal cell carcinoma is currently one of the most interesting areas of study in oncology. Despite the advances made in this field, this tumor continues to be a health problem of major concern in Western societies, seriously affecting public health services. Several characteristics of this...
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| Format: | Online |
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| Jezik: | engleski |
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MDPI - Multidisciplinary Digital Publishing Institute
2022
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| Online pristup: | ONIX_20221117_9783036555188_45 |
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Bez oznaka, Budi prvi tko označuje ovaj zapis!
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| collection | Directory of Open Access Books |
| description | Clear cell renal cell carcinoma is currently one of the most interesting areas of study in oncology. Despite the advances made in this field, this tumor continues to be a health problem of major concern in Western societies, seriously affecting public health services. Several characteristics of this tumor make it an exciting meeting point for translational collaboration between clinicians and basic researchers. Clear cell renal cell carcinoma is a paradigmatic example of inter- and intra-tumor heterogeneity from morphological, immunohistochemical, and molecular viewpoints. This tumor is also a good example to investigate the complexity of tumor/tumor and tumor/environment relationships from an ecological perspective. A deeper identification of the varied internal tumor self-organization through the specialization of cell clones and subclones as local invaders and metastasizers, on one hand, and the interactions of specific subsets of tumor cells with the local host microenvironment, on the other, will significantly enrich our knowledge of this neoplasm. Clear cell renal cell carcinoma is also a paradigmatic test bench for antiangiogenic and immune checkpoint blockage therapies. The refinement of these therapeutic tools administered alone or in combination is a hot issue in oncology, and several international trials are underway. |
| format | Online |
| id | doab-20.500.12854ir-93788 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2022 |
| publishDateRange | 2022 |
| publishDateSort | 2022 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-937882024-03-31T13:10:36Z Clear Cell Renal Cell Carcinoma 2021–2022 Manini, Claudia López, José I. clear cell renal cell carcinoma prognosis plasma PD-1 PD-L1 renal cell carcinoma immune checkpoint inhibitors immune related adverse events (irAEs) thyroid cutaneous biomarker DNA methylation epigenetics kidney hypoxia tumor microenvironment SCD-1 oleic acid renal cancer sunitinib resistance miRNA transcriptome pathway analysis nivolumab tissue slice culture PD1 T-cells metastatic clear cell renal cell carcinoma first-line treatment immunotherapy tyrosine kinase inhibitors combinations single-cell RNA sequencing immune landscape cancer immunotherapy intra-tumoral heterogeneity inter-tumoral heterogeneity inter-metastatic heterogeneity renal cell cancer treatment resistance angiogenesis adjuvant therapy prediction model prognostic factor clear cell kidney cancer radiogenomics radiomics machine learning gene expression cystic tumor imaging magnetic resonance surgery ddPCR circulating miRNA diagnosis malignancy histomorphological features PBRM1 immunohistochemistry architectural patterns endothelial cells translational immune checkpoint inhibitor responsiveness molecular features multisite tumor sampling intratumor heterogeneity clear-cell renal cell carcinoma disease progression prognostic factors biomarkers RNA sequencing n/a thema EDItEUR::M Medicine and Nursing thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine Clear cell renal cell carcinoma is currently one of the most interesting areas of study in oncology. Despite the advances made in this field, this tumor continues to be a health problem of major concern in Western societies, seriously affecting public health services. Several characteristics of this tumor make it an exciting meeting point for translational collaboration between clinicians and basic researchers. Clear cell renal cell carcinoma is a paradigmatic example of inter- and intra-tumor heterogeneity from morphological, immunohistochemical, and molecular viewpoints. This tumor is also a good example to investigate the complexity of tumor/tumor and tumor/environment relationships from an ecological perspective. A deeper identification of the varied internal tumor self-organization through the specialization of cell clones and subclones as local invaders and metastasizers, on one hand, and the interactions of specific subsets of tumor cells with the local host microenvironment, on the other, will significantly enrich our knowledge of this neoplasm. Clear cell renal cell carcinoma is also a paradigmatic test bench for antiangiogenic and immune checkpoint blockage therapies. The refinement of these therapeutic tools administered alone or in combination is a hot issue in oncology, and several international trials are underway. 2022-11-17T16:24:41Z 2022-11-17T16:24:41Z 2022 book ONIX_20221117_9783036555188_45 9783036555188 9783036555171 https://directory.doabooks.org/handle/20.500.12854/93788 eng image/jpeg Attribution 4.0 International https://mdpi.com/books/pdfview/book/6216 https://mdpi.com/books/pdfview/book/6216 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-0365-5518-8 10.3390/books978-3-0365-5518-8 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783036555188 9783036555171 342 Basel open access |
| spellingShingle | clear cell renal cell carcinoma prognosis plasma PD-1 PD-L1 renal cell carcinoma immune checkpoint inhibitors immune related adverse events (irAEs) thyroid cutaneous biomarker DNA methylation epigenetics kidney hypoxia tumor microenvironment SCD-1 oleic acid renal cancer sunitinib resistance miRNA transcriptome pathway analysis nivolumab tissue slice culture PD1 T-cells metastatic clear cell renal cell carcinoma first-line treatment immunotherapy tyrosine kinase inhibitors combinations single-cell RNA sequencing immune landscape cancer immunotherapy intra-tumoral heterogeneity inter-tumoral heterogeneity inter-metastatic heterogeneity renal cell cancer treatment resistance angiogenesis adjuvant therapy prediction model prognostic factor clear cell kidney cancer radiogenomics radiomics machine learning gene expression cystic tumor imaging magnetic resonance surgery ddPCR circulating miRNA diagnosis malignancy histomorphological features PBRM1 immunohistochemistry architectural patterns endothelial cells translational immune checkpoint inhibitor responsiveness molecular features multisite tumor sampling intratumor heterogeneity clear-cell renal cell carcinoma disease progression prognostic factors biomarkers RNA sequencing n/a thema EDItEUR::M Medicine and Nursing thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine Clear Cell Renal Cell Carcinoma 2021–2022 |
| title | Clear Cell Renal Cell Carcinoma 2021–2022 |
| title_full | Clear Cell Renal Cell Carcinoma 2021–2022 |
| title_fullStr | Clear Cell Renal Cell Carcinoma 2021–2022 |
| title_full_unstemmed | Clear Cell Renal Cell Carcinoma 2021–2022 |
| title_short | Clear Cell Renal Cell Carcinoma 2021–2022 |
| title_sort | clear cell renal cell carcinoma 2021 2022 |
| topic | clear cell renal cell carcinoma prognosis plasma PD-1 PD-L1 renal cell carcinoma immune checkpoint inhibitors immune related adverse events (irAEs) thyroid cutaneous biomarker DNA methylation epigenetics kidney hypoxia tumor microenvironment SCD-1 oleic acid renal cancer sunitinib resistance miRNA transcriptome pathway analysis nivolumab tissue slice culture PD1 T-cells metastatic clear cell renal cell carcinoma first-line treatment immunotherapy tyrosine kinase inhibitors combinations single-cell RNA sequencing immune landscape cancer immunotherapy intra-tumoral heterogeneity inter-tumoral heterogeneity inter-metastatic heterogeneity renal cell cancer treatment resistance angiogenesis adjuvant therapy prediction model prognostic factor clear cell kidney cancer radiogenomics radiomics machine learning gene expression cystic tumor imaging magnetic resonance surgery ddPCR circulating miRNA diagnosis malignancy histomorphological features PBRM1 immunohistochemistry architectural patterns endothelial cells translational immune checkpoint inhibitor responsiveness molecular features multisite tumor sampling intratumor heterogeneity clear-cell renal cell carcinoma disease progression prognostic factors biomarkers RNA sequencing n/a thema EDItEUR::M Medicine and Nursing thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine |
| topic_facet | clear cell renal cell carcinoma prognosis plasma PD-1 PD-L1 renal cell carcinoma immune checkpoint inhibitors immune related adverse events (irAEs) thyroid cutaneous biomarker DNA methylation epigenetics kidney hypoxia tumor microenvironment SCD-1 oleic acid renal cancer sunitinib resistance miRNA transcriptome pathway analysis nivolumab tissue slice culture PD1 T-cells metastatic clear cell renal cell carcinoma first-line treatment immunotherapy tyrosine kinase inhibitors combinations single-cell RNA sequencing immune landscape cancer immunotherapy intra-tumoral heterogeneity inter-tumoral heterogeneity inter-metastatic heterogeneity renal cell cancer treatment resistance angiogenesis adjuvant therapy prediction model prognostic factor clear cell kidney cancer radiogenomics radiomics machine learning gene expression cystic tumor imaging magnetic resonance surgery ddPCR circulating miRNA diagnosis malignancy histomorphological features PBRM1 immunohistochemistry architectural patterns endothelial cells translational immune checkpoint inhibitor responsiveness molecular features multisite tumor sampling intratumor heterogeneity clear-cell renal cell carcinoma disease progression prognostic factors biomarkers RNA sequencing n/a thema EDItEUR::M Medicine and Nursing thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine |
| url | ONIX_20221117_9783036555188_45 |