EPR Effect-Based Tumor Targeted Nanomedicine
I am honored to undertake the work for Guest Editor for this Special Issue of EPR Effect-Based Tumor Targeted Nanomedicine for the Journal of Personalized Medicine. It has already been 35 years since we published the concept of the EPR effect for the first time. The discovery of the new concept of E...
সংরক্ষণ করুন:
| বিন্যাস: | Online |
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| ভাষা: | ইংরেজি |
| প্রকাশিত: |
MDPI - Multidisciplinary Digital Publishing Institute
2022
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| বিষয়গুলি: | |
| অনলাইন ব্যবহার করুন: | ONIX_20221117_9783036554273_54 |
| ট্যাগগুলো: |
কোনো ট্যাগ নেই, প্রথমজন হিসাবে ট্যাগ করুন!
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| _version_ | 1869527910522552320 |
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| collection | Directory of Open Access Books |
| description | I am honored to undertake the work for Guest Editor for this Special Issue of EPR Effect-Based Tumor Targeted Nanomedicine for the Journal of Personalized Medicine. It has already been 35 years since we published the concept of the EPR effect for the first time. The discovery of the new concept of EPR effect gave an impetus effect of growth momentum in nanomedicine, and numerous works are focused on tumor delivery, although the initial idea was based on vascular permeability in infection-induced inflamed tissue, where we discovered bradykinin in the key mediator of vascular permeability.I know, however, there are pros and cons to EPR effect. Cons stem either from a poor understanding of EPR effect, or somehow a biased view of the EPR effect, or from the tumor models being used, particularly in the clinical settings where vascular blood flow is so frequently obstructed. I hope scientists in the clinic, or basic researchers working on the tumor drug delivery, will join the forum of this Special Issue and express their data and opinions.The scope of this issue includes an in-depth understanding of the EPR effect, and issues associated with tumor microenvironment and also further exploitation of EPR effect in human cancer. In addition, new strategies for enhancement of the EPR effect using nanomedicine will be welcome, which is as important as the EPR effect itself. These papers cover not only cancer therapy, but also imaging techniques using nanofluorescent agents, including photodynamic therapy for inflammation, and boron neutron capture therapy. |
| format | Online |
| id | doab-20.500.12854ir-93797 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2022 |
| publishDateRange | 2022 |
| publishDateSort | 2022 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-937972024-03-31T13:10:44Z EPR Effect-Based Tumor Targeted Nanomedicine Maeda, Hiroshi extracellular matrix drug delivery tumor cancer targeting reactive oxygen species antioxidant self-assembling drug HPMA copolymers EPR effect controlled release nanomedicines nanoparticles tumor vascular regulation angiogenesis blood perfusion vascular permeability tumor targeting photodynamic hyaluronan zinc protoporphyrin enhanced permeability and retention effect cancer therapy nanotechnology tumor-selective drug delivery photodynamic therapy boron neutron capture therapy isosorbide dinitrate sildenafil citrate EPR-effect enhancers heterogeneity of the EPR effect nitric oxide donors tumor blood flow TNBC dasatinib poly(styrene-co-maleic acid) micelles nanoformulation metabolism EPR nanomedicine targeted therapy solid cancer microenvironment hypoxia DDS anaerobic bacteria Bifidobacterium bacterial therapy iDPS EPR-based therapy passive targeting heterogeneity solid-tumor EPR-imaging techniques sildenafil phosphodiesterase 5 inhibitors drug repurposing chemoadjuvant arterial infusion canine cancer particle beam therapy proton beam therapy carbon-ion beam therapy combination therapy iNaD siRNA microRNA calcium phosphate PEG blending cancer treatment n/a thema EDItEUR::M Medicine and Nursing thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCL Oncology I am honored to undertake the work for Guest Editor for this Special Issue of EPR Effect-Based Tumor Targeted Nanomedicine for the Journal of Personalized Medicine. It has already been 35 years since we published the concept of the EPR effect for the first time. The discovery of the new concept of EPR effect gave an impetus effect of growth momentum in nanomedicine, and numerous works are focused on tumor delivery, although the initial idea was based on vascular permeability in infection-induced inflamed tissue, where we discovered bradykinin in the key mediator of vascular permeability.I know, however, there are pros and cons to EPR effect. Cons stem either from a poor understanding of EPR effect, or somehow a biased view of the EPR effect, or from the tumor models being used, particularly in the clinical settings where vascular blood flow is so frequently obstructed. I hope scientists in the clinic, or basic researchers working on the tumor drug delivery, will join the forum of this Special Issue and express their data and opinions.The scope of this issue includes an in-depth understanding of the EPR effect, and issues associated with tumor microenvironment and also further exploitation of EPR effect in human cancer. In addition, new strategies for enhancement of the EPR effect using nanomedicine will be welcome, which is as important as the EPR effect itself. These papers cover not only cancer therapy, but also imaging techniques using nanofluorescent agents, including photodynamic therapy for inflammation, and boron neutron capture therapy. 2022-11-17T16:25:17Z 2022-11-17T16:25:17Z 2022 book ONIX_20221117_9783036554273_54 9783036554273 9783036554280 https://directory.doabooks.org/handle/20.500.12854/93797 eng image/jpeg Attribution 4.0 International https://mdpi.com/books/pdfview/book/6226 https://mdpi.com/books/pdfview/book/6226 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-0365-5427-3 10.3390/books978-3-0365-5427-3 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783036554273 9783036554280 290 Basel open access |
| spellingShingle | extracellular matrix drug delivery tumor cancer targeting reactive oxygen species antioxidant self-assembling drug HPMA copolymers EPR effect controlled release nanomedicines nanoparticles tumor vascular regulation angiogenesis blood perfusion vascular permeability tumor targeting photodynamic hyaluronan zinc protoporphyrin enhanced permeability and retention effect cancer therapy nanotechnology tumor-selective drug delivery photodynamic therapy boron neutron capture therapy isosorbide dinitrate sildenafil citrate EPR-effect enhancers heterogeneity of the EPR effect nitric oxide donors tumor blood flow TNBC dasatinib poly(styrene-co-maleic acid) micelles nanoformulation metabolism EPR nanomedicine targeted therapy solid cancer microenvironment hypoxia DDS anaerobic bacteria Bifidobacterium bacterial therapy iDPS EPR-based therapy passive targeting heterogeneity solid-tumor EPR-imaging techniques sildenafil phosphodiesterase 5 inhibitors drug repurposing chemoadjuvant arterial infusion canine cancer particle beam therapy proton beam therapy carbon-ion beam therapy combination therapy iNaD siRNA microRNA calcium phosphate PEG blending cancer treatment n/a thema EDItEUR::M Medicine and Nursing thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCL Oncology EPR Effect-Based Tumor Targeted Nanomedicine |
| title | EPR Effect-Based Tumor Targeted Nanomedicine |
| title_full | EPR Effect-Based Tumor Targeted Nanomedicine |
| title_fullStr | EPR Effect-Based Tumor Targeted Nanomedicine |
| title_full_unstemmed | EPR Effect-Based Tumor Targeted Nanomedicine |
| title_short | EPR Effect-Based Tumor Targeted Nanomedicine |
| title_sort | epr effect based tumor targeted nanomedicine |
| topic | extracellular matrix drug delivery tumor cancer targeting reactive oxygen species antioxidant self-assembling drug HPMA copolymers EPR effect controlled release nanomedicines nanoparticles tumor vascular regulation angiogenesis blood perfusion vascular permeability tumor targeting photodynamic hyaluronan zinc protoporphyrin enhanced permeability and retention effect cancer therapy nanotechnology tumor-selective drug delivery photodynamic therapy boron neutron capture therapy isosorbide dinitrate sildenafil citrate EPR-effect enhancers heterogeneity of the EPR effect nitric oxide donors tumor blood flow TNBC dasatinib poly(styrene-co-maleic acid) micelles nanoformulation metabolism EPR nanomedicine targeted therapy solid cancer microenvironment hypoxia DDS anaerobic bacteria Bifidobacterium bacterial therapy iDPS EPR-based therapy passive targeting heterogeneity solid-tumor EPR-imaging techniques sildenafil phosphodiesterase 5 inhibitors drug repurposing chemoadjuvant arterial infusion canine cancer particle beam therapy proton beam therapy carbon-ion beam therapy combination therapy iNaD siRNA microRNA calcium phosphate PEG blending cancer treatment n/a thema EDItEUR::M Medicine and Nursing thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCL Oncology |
| topic_facet | extracellular matrix drug delivery tumor cancer targeting reactive oxygen species antioxidant self-assembling drug HPMA copolymers EPR effect controlled release nanomedicines nanoparticles tumor vascular regulation angiogenesis blood perfusion vascular permeability tumor targeting photodynamic hyaluronan zinc protoporphyrin enhanced permeability and retention effect cancer therapy nanotechnology tumor-selective drug delivery photodynamic therapy boron neutron capture therapy isosorbide dinitrate sildenafil citrate EPR-effect enhancers heterogeneity of the EPR effect nitric oxide donors tumor blood flow TNBC dasatinib poly(styrene-co-maleic acid) micelles nanoformulation metabolism EPR nanomedicine targeted therapy solid cancer microenvironment hypoxia DDS anaerobic bacteria Bifidobacterium bacterial therapy iDPS EPR-based therapy passive targeting heterogeneity solid-tumor EPR-imaging techniques sildenafil phosphodiesterase 5 inhibitors drug repurposing chemoadjuvant arterial infusion canine cancer particle beam therapy proton beam therapy carbon-ion beam therapy combination therapy iNaD siRNA microRNA calcium phosphate PEG blending cancer treatment n/a thema EDItEUR::M Medicine and Nursing thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCL Oncology |
| url | ONIX_20221117_9783036554273_54 |