New Insights into Molecular Mechanisms Underlying Neurodegenerative Disorders
Neurodegenerative disorders encompass a broad range of sporadic and/or familial debilitating conditions characterized by the progressive dysfunction and loss of selective neuronal populations, determining different clinical phenotypes. Emerging research data indicate an interplay of genetic factors...
محفوظ في:
| التنسيق: | Online |
|---|---|
| اللغة: | الإنجليزية |
| منشور في: |
MDPI - Multidisciplinary Digital Publishing Institute
2022
|
| الموضوعات: | |
| الوصول للمادة أونلاين: | ONIX_20221117_9783036554853_86 |
| الوسوم: |
لا توجد وسوم, كن أول من يضع وسما على هذه التسجيلة!
|
| _version_ | 1869526981013405696 |
|---|---|
| collection | Directory of Open Access Books |
| description | Neurodegenerative disorders encompass a broad range of sporadic and/or familial debilitating conditions characterized by the progressive dysfunction and loss of selective neuronal populations, determining different clinical phenotypes. Emerging research data indicate an interplay of genetic factors and epigenetic mechanisms underlying neurodegenerative processes, which lead to increased prevalence of neurodegenerative disorders. In concert with the constant increase in the aging population, neurodegenerative disorders currently represent a major challenge to public health worldwide. Despite recent advances in clinical and preclinical research, the pathogenesis of these disorders still remains poorly understood, without effective treatments being available to halt the neurodegenerative processes, but rather aiming at relieving symptoms. Therefore, a critical evaluation of current research data and in-depth understanding of the molecular mechanisms that lead to neurodegeneration are crucial in order to identify potential therapeutic targets that can pave the way to the development of novel and promising therapies. This Special Issue is focused on novel molecular data in the field of neurodegeneration that associate with the onset and progression of neurodegenerative diseases. We are particularly interested in original articles and reviews that provide new insights into the main molecular pathogenic mechanisms underlying neurodegenerative disorders, aiming to identify potential biomarkers and novel therapeutic strategies. |
| format | Online |
| id | doab-20.500.12854ir-93829 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2022 |
| publishDateRange | 2022 |
| publishDateSort | 2022 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-938292024-03-28T03:33:49Z New Insights into Molecular Mechanisms Underlying Neurodegenerative Disorders Villa, Chiara Paudel, Yam Nath Piperi, Christina Parkinson’s disease schizophrenia Mendelian randomization genetics TLRs neuroinflammation neuroprotection neurodegeneration Parkinson’s disease Alzheimer’s disease aducanumab LMICs APOE burden of disease treatment cost Parkinson disease epigenetics DNA methylation histone modifications lcRNAs environmental toxins smoking pesticides coffee diagnosis stochasticity space-time entropy neurodegeneration EEG MEG graph theory Alzheimer Parkinson Interleukin-37 central nervous system diseases inflammatory anti-inflammatory cytokines gut microbiota gut–brain axis dysbiosis homology modelling LOMETS MUSTER iGEMDOCK AutoDock vina MPTP model mice tyrosine hydroxylase phosphorylation neuroplasticity Alzheimer’s disease viral hypothesis human herpesviruses amyloid beta (Aβ) tau protein n/a levodopa-induced dyskinesia circular RNA next-generation sequencing thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences Neurodegenerative disorders encompass a broad range of sporadic and/or familial debilitating conditions characterized by the progressive dysfunction and loss of selective neuronal populations, determining different clinical phenotypes. Emerging research data indicate an interplay of genetic factors and epigenetic mechanisms underlying neurodegenerative processes, which lead to increased prevalence of neurodegenerative disorders. In concert with the constant increase in the aging population, neurodegenerative disorders currently represent a major challenge to public health worldwide. Despite recent advances in clinical and preclinical research, the pathogenesis of these disorders still remains poorly understood, without effective treatments being available to halt the neurodegenerative processes, but rather aiming at relieving symptoms. Therefore, a critical evaluation of current research data and in-depth understanding of the molecular mechanisms that lead to neurodegeneration are crucial in order to identify potential therapeutic targets that can pave the way to the development of novel and promising therapies. This Special Issue is focused on novel molecular data in the field of neurodegeneration that associate with the onset and progression of neurodegenerative diseases. We are particularly interested in original articles and reviews that provide new insights into the main molecular pathogenic mechanisms underlying neurodegenerative disorders, aiming to identify potential biomarkers and novel therapeutic strategies. 2022-11-17T16:26:49Z 2022-11-17T16:26:49Z 2022 book ONIX_20221117_9783036554853_86 9783036554853 9783036554860 https://directory.doabooks.org/handle/20.500.12854/93829 eng image/jpeg Attribution 4.0 International https://mdpi.com/books/pdfview/book/6258 https://mdpi.com/books/pdfview/book/6258 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-0365-5485-3 10.3390/books978-3-0365-5485-3 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783036554853 9783036554860 194 Basel open access |
| spellingShingle | Parkinson’s disease schizophrenia Mendelian randomization genetics TLRs neuroinflammation neuroprotection neurodegeneration Parkinson’s disease Alzheimer’s disease aducanumab LMICs APOE burden of disease treatment cost Parkinson disease epigenetics DNA methylation histone modifications lcRNAs environmental toxins smoking pesticides coffee diagnosis stochasticity space-time entropy neurodegeneration EEG MEG graph theory Alzheimer Parkinson Interleukin-37 central nervous system diseases inflammatory anti-inflammatory cytokines gut microbiota gut–brain axis dysbiosis homology modelling LOMETS MUSTER iGEMDOCK AutoDock vina MPTP model mice tyrosine hydroxylase phosphorylation neuroplasticity Alzheimer’s disease viral hypothesis human herpesviruses amyloid beta (Aβ) tau protein n/a levodopa-induced dyskinesia circular RNA next-generation sequencing thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences New Insights into Molecular Mechanisms Underlying Neurodegenerative Disorders |
| title | New Insights into Molecular Mechanisms Underlying Neurodegenerative Disorders |
| title_full | New Insights into Molecular Mechanisms Underlying Neurodegenerative Disorders |
| title_fullStr | New Insights into Molecular Mechanisms Underlying Neurodegenerative Disorders |
| title_full_unstemmed | New Insights into Molecular Mechanisms Underlying Neurodegenerative Disorders |
| title_short | New Insights into Molecular Mechanisms Underlying Neurodegenerative Disorders |
| title_sort | new insights into molecular mechanisms underlying neurodegenerative disorders |
| topic | Parkinson’s disease schizophrenia Mendelian randomization genetics TLRs neuroinflammation neuroprotection neurodegeneration Parkinson’s disease Alzheimer’s disease aducanumab LMICs APOE burden of disease treatment cost Parkinson disease epigenetics DNA methylation histone modifications lcRNAs environmental toxins smoking pesticides coffee diagnosis stochasticity space-time entropy neurodegeneration EEG MEG graph theory Alzheimer Parkinson Interleukin-37 central nervous system diseases inflammatory anti-inflammatory cytokines gut microbiota gut–brain axis dysbiosis homology modelling LOMETS MUSTER iGEMDOCK AutoDock vina MPTP model mice tyrosine hydroxylase phosphorylation neuroplasticity Alzheimer’s disease viral hypothesis human herpesviruses amyloid beta (Aβ) tau protein n/a levodopa-induced dyskinesia circular RNA next-generation sequencing thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences |
| topic_facet | Parkinson’s disease schizophrenia Mendelian randomization genetics TLRs neuroinflammation neuroprotection neurodegeneration Parkinson’s disease Alzheimer’s disease aducanumab LMICs APOE burden of disease treatment cost Parkinson disease epigenetics DNA methylation histone modifications lcRNAs environmental toxins smoking pesticides coffee diagnosis stochasticity space-time entropy neurodegeneration EEG MEG graph theory Alzheimer Parkinson Interleukin-37 central nervous system diseases inflammatory anti-inflammatory cytokines gut microbiota gut–brain axis dysbiosis homology modelling LOMETS MUSTER iGEMDOCK AutoDock vina MPTP model mice tyrosine hydroxylase phosphorylation neuroplasticity Alzheimer’s disease viral hypothesis human herpesviruses amyloid beta (Aβ) tau protein n/a levodopa-induced dyskinesia circular RNA next-generation sequencing thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences |
| url | ONIX_20221117_9783036554853_86 |