Viruses and Nuclear Egress
This Special Issue of Viruses focuses on the topic of viruses and nuclear egress. Nuclear egress is a fascinating process by which herpesvirus nucleocapsids make their way from the nuclear interior to the cytoplasm. As nuclear egress and the viral proteins that orchestrate it differ from host proces...
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| 格式: | Online |
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| 語言: | 英语 |
| 出版: |
MDPI - Multidisciplinary Digital Publishing Institute
2022
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| 在線閱讀: | ONIX_20221117_9783036556956_118 |
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| _version_ | 1869521419528830976 |
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| collection | Directory of Open Access Books |
| description | This Special Issue of Viruses focuses on the topic of viruses and nuclear egress. Nuclear egress is a fascinating process by which herpesvirus nucleocapsids make their way from the nuclear interior to the cytoplasm. As nuclear egress and the viral proteins that orchestrate it differ from host processes and proteins in important ways, there is interest in targeting antiviral therapies to disrupt this process. Indeed, the recently approved drug maribavir acts in large part by inhibiting a step of nuclear egress. The Special Issue includes five reviews—three on nuclear egress of two alphaherpesviruses, herpes simplex virus and pseudorabies virus; one on a betaherpevirus, human cytomegalovirus; and one on a gammaherpesvirus, Epstein–Barr virus—and five research papers—two on alphaherpesviruses and three on human cytomegalovirus. |
| format | Online |
| id | doab-20.500.12854ir-93861 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2022 |
| publishDateRange | 2022 |
| publishDateSort | 2022 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-938612024-03-28T03:31:14Z Viruses and Nuclear Egress Coen, Donald M. human cytomegalovirus core nuclear egress complex ORF-UL50 deletion pUL50 phosphosite mutants phenotypical changes differential functional relevance Epstein–Barr virus BGLF4 kinase nuclear egress BFRF1 nuclear envelope modulation herpesviruses primary envelopment de-envelopment herpesvirus pseudorabies virus PrV vesicle-associated membrane protein associated protein VAPA VAPB CRISPR/Cas9 genome editing enveloped virus budding ESCRT membrane scission HSV1 pUL34 pUL31 NEC targeting integral membrane proteins TA membrane proteins inner nuclear membrane (INM) nuclear import importins n/a CMV peptide therapy tegument phosphorylation nuclear envelopment complex membrane fusion hemi-fusion virus assembly virus–cell interactions capsid migration UL53 UL50 myosin Va major capsid protein mass spectrometry virus genetics complementing cells null mutants thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSG Microbiology (non-medical) This Special Issue of Viruses focuses on the topic of viruses and nuclear egress. Nuclear egress is a fascinating process by which herpesvirus nucleocapsids make their way from the nuclear interior to the cytoplasm. As nuclear egress and the viral proteins that orchestrate it differ from host processes and proteins in important ways, there is interest in targeting antiviral therapies to disrupt this process. Indeed, the recently approved drug maribavir acts in large part by inhibiting a step of nuclear egress. The Special Issue includes five reviews—three on nuclear egress of two alphaherpesviruses, herpes simplex virus and pseudorabies virus; one on a betaherpevirus, human cytomegalovirus; and one on a gammaherpesvirus, Epstein–Barr virus—and five research papers—two on alphaherpesviruses and three on human cytomegalovirus. 2022-11-17T16:28:14Z 2022-11-17T16:28:14Z 2022 book ONIX_20221117_9783036556956_118 9783036556956 9783036556963 https://directory.doabooks.org/handle/20.500.12854/93861 eng image/jpeg Attribution 4.0 International https://mdpi.com/books/pdfview/book/6291 https://mdpi.com/books/pdfview/book/6291 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-0365-5695-6 10.3390/books978-3-0365-5695-6 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783036556956 9783036556963 182 Basel open access |
| spellingShingle | human cytomegalovirus core nuclear egress complex ORF-UL50 deletion pUL50 phosphosite mutants phenotypical changes differential functional relevance Epstein–Barr virus BGLF4 kinase nuclear egress BFRF1 nuclear envelope modulation herpesviruses primary envelopment de-envelopment herpesvirus pseudorabies virus PrV vesicle-associated membrane protein associated protein VAPA VAPB CRISPR/Cas9 genome editing enveloped virus budding ESCRT membrane scission HSV1 pUL34 pUL31 NEC targeting integral membrane proteins TA membrane proteins inner nuclear membrane (INM) nuclear import importins n/a CMV peptide therapy tegument phosphorylation nuclear envelopment complex membrane fusion hemi-fusion virus assembly virus–cell interactions capsid migration UL53 UL50 myosin Va major capsid protein mass spectrometry virus genetics complementing cells null mutants thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSG Microbiology (non-medical) Viruses and Nuclear Egress |
| title | Viruses and Nuclear Egress |
| title_full | Viruses and Nuclear Egress |
| title_fullStr | Viruses and Nuclear Egress |
| title_full_unstemmed | Viruses and Nuclear Egress |
| title_short | Viruses and Nuclear Egress |
| title_sort | viruses and nuclear egress |
| topic | human cytomegalovirus core nuclear egress complex ORF-UL50 deletion pUL50 phosphosite mutants phenotypical changes differential functional relevance Epstein–Barr virus BGLF4 kinase nuclear egress BFRF1 nuclear envelope modulation herpesviruses primary envelopment de-envelopment herpesvirus pseudorabies virus PrV vesicle-associated membrane protein associated protein VAPA VAPB CRISPR/Cas9 genome editing enveloped virus budding ESCRT membrane scission HSV1 pUL34 pUL31 NEC targeting integral membrane proteins TA membrane proteins inner nuclear membrane (INM) nuclear import importins n/a CMV peptide therapy tegument phosphorylation nuclear envelopment complex membrane fusion hemi-fusion virus assembly virus–cell interactions capsid migration UL53 UL50 myosin Va major capsid protein mass spectrometry virus genetics complementing cells null mutants thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSG Microbiology (non-medical) |
| topic_facet | human cytomegalovirus core nuclear egress complex ORF-UL50 deletion pUL50 phosphosite mutants phenotypical changes differential functional relevance Epstein–Barr virus BGLF4 kinase nuclear egress BFRF1 nuclear envelope modulation herpesviruses primary envelopment de-envelopment herpesvirus pseudorabies virus PrV vesicle-associated membrane protein associated protein VAPA VAPB CRISPR/Cas9 genome editing enveloped virus budding ESCRT membrane scission HSV1 pUL34 pUL31 NEC targeting integral membrane proteins TA membrane proteins inner nuclear membrane (INM) nuclear import importins n/a CMV peptide therapy tegument phosphorylation nuclear envelopment complex membrane fusion hemi-fusion virus assembly virus–cell interactions capsid migration UL53 UL50 myosin Va major capsid protein mass spectrometry virus genetics complementing cells null mutants thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSG Microbiology (non-medical) |
| url | ONIX_20221117_9783036556956_118 |