Pathophysiology of Spinal Cord Injury (SCI)
Spinal cord injury (SCI) leads to paralysis, sensory, and autonomic nervous system dysfunctions. However, the pathophysiology of SCI is complex, and not limited to the nervous system. Indeed, several other organs and tissue are also affected by the injury, directly or not, acutely or chronically, wh...
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| Materiálatiipa: | Online |
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| Giella: | eaŋgalasgiella |
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MDPI - Multidisciplinary Digital Publishing Institute
2023
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| Liŋkkat: | ONIX_20230105_9783036558882_10 |
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| _version_ | 1869526868474986496 |
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| collection | Directory of Open Access Books |
| description | Spinal cord injury (SCI) leads to paralysis, sensory, and autonomic nervous system dysfunctions. However, the pathophysiology of SCI is complex, and not limited to the nervous system. Indeed, several other organs and tissue are also affected by the injury, directly or not, acutely or chronically, which induces numerous health complications. Although a lot of research has been performed to repair motor and sensory functions, SCI-induced health issues are less studied, although they represent a major concern among patients. There is a gap of knowledge in pre-clinical models studying these SCI-induced health complications that limits translational applications in humans. This reprint describes several aspects of the pathophysiology of spinal cord injuries. This includes, but is not limited to, the impact of SCI on cardiovascular and respiratory functions, bladder and bowel function, autonomic dysreflexia, liver pathology, metabolic syndrome, bones and muscles loss, and cognitive functions. |
| format | Online |
| id | doab-20.500.12854ir-95781 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2023 |
| publishDateRange | 2023 |
| publishDateSort | 2023 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-957812024-03-31T13:08:32Z Pathophysiology of Spinal Cord Injury (SCI) Geoffroy, Cédric Alilain, Warren micturition external urethral sphincter spinal cord injury serotonin electromyogram fecal microbiota transplant inflammation anxiety rehabilitation autonomic dysreflexia immune dysfunction SCI-IDS primary afferents nociceptor reach-to-grasp forelimb function upper extremity function cardiovascular contusion neuroplasticity osteopenia bone loss recovery of function monoamines GABA neuromodulation pain spasticity ionic plasticity repetitive transcranial magnetic stimulation phrenic motor network motoneuron excitability diaphragm muscle spinal cord injury severity cardiometabolic disease liver and cardiac dysfunctions fibrosis pathophysiology oxidative stress contusion model respiratory function diaphragmatic activity phrenic motoneurons neuroinflammation cytokines tumor necrosis factor immune cells microglia thema EDItEUR::M Medicine and Nursing thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences Spinal cord injury (SCI) leads to paralysis, sensory, and autonomic nervous system dysfunctions. However, the pathophysiology of SCI is complex, and not limited to the nervous system. Indeed, several other organs and tissue are also affected by the injury, directly or not, acutely or chronically, which induces numerous health complications. Although a lot of research has been performed to repair motor and sensory functions, SCI-induced health issues are less studied, although they represent a major concern among patients. There is a gap of knowledge in pre-clinical models studying these SCI-induced health complications that limits translational applications in humans. This reprint describes several aspects of the pathophysiology of spinal cord injuries. This includes, but is not limited to, the impact of SCI on cardiovascular and respiratory functions, bladder and bowel function, autonomic dysreflexia, liver pathology, metabolic syndrome, bones and muscles loss, and cognitive functions. 2023-01-05T12:32:25Z 2023-01-05T12:32:25Z 2022 book ONIX_20230105_9783036558882_10 9783036558882 9783036558875 https://directory.doabooks.org/handle/20.500.12854/95781 eng image/jpeg Attribution 4.0 International https://mdpi.com/books/pdfview/book/6437 https://mdpi.com/books/pdfview/book/6437 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-0365-5887-5 10.3390/books978-3-0365-5887-5 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783036558882 9783036558875 258 Basel open access |
| spellingShingle | micturition external urethral sphincter spinal cord injury serotonin electromyogram fecal microbiota transplant inflammation anxiety rehabilitation autonomic dysreflexia immune dysfunction SCI-IDS primary afferents nociceptor reach-to-grasp forelimb function upper extremity function cardiovascular contusion neuroplasticity osteopenia bone loss recovery of function monoamines GABA neuromodulation pain spasticity ionic plasticity repetitive transcranial magnetic stimulation phrenic motor network motoneuron excitability diaphragm muscle spinal cord injury severity cardiometabolic disease liver and cardiac dysfunctions fibrosis pathophysiology oxidative stress contusion model respiratory function diaphragmatic activity phrenic motoneurons neuroinflammation cytokines tumor necrosis factor immune cells microglia thema EDItEUR::M Medicine and Nursing thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences Pathophysiology of Spinal Cord Injury (SCI) |
| title | Pathophysiology of Spinal Cord Injury (SCI) |
| title_full | Pathophysiology of Spinal Cord Injury (SCI) |
| title_fullStr | Pathophysiology of Spinal Cord Injury (SCI) |
| title_full_unstemmed | Pathophysiology of Spinal Cord Injury (SCI) |
| title_short | Pathophysiology of Spinal Cord Injury (SCI) |
| title_sort | pathophysiology of spinal cord injury sci |
| topic | micturition external urethral sphincter spinal cord injury serotonin electromyogram fecal microbiota transplant inflammation anxiety rehabilitation autonomic dysreflexia immune dysfunction SCI-IDS primary afferents nociceptor reach-to-grasp forelimb function upper extremity function cardiovascular contusion neuroplasticity osteopenia bone loss recovery of function monoamines GABA neuromodulation pain spasticity ionic plasticity repetitive transcranial magnetic stimulation phrenic motor network motoneuron excitability diaphragm muscle spinal cord injury severity cardiometabolic disease liver and cardiac dysfunctions fibrosis pathophysiology oxidative stress contusion model respiratory function diaphragmatic activity phrenic motoneurons neuroinflammation cytokines tumor necrosis factor immune cells microglia thema EDItEUR::M Medicine and Nursing thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences |
| topic_facet | micturition external urethral sphincter spinal cord injury serotonin electromyogram fecal microbiota transplant inflammation anxiety rehabilitation autonomic dysreflexia immune dysfunction SCI-IDS primary afferents nociceptor reach-to-grasp forelimb function upper extremity function cardiovascular contusion neuroplasticity osteopenia bone loss recovery of function monoamines GABA neuromodulation pain spasticity ionic plasticity repetitive transcranial magnetic stimulation phrenic motor network motoneuron excitability diaphragm muscle spinal cord injury severity cardiometabolic disease liver and cardiac dysfunctions fibrosis pathophysiology oxidative stress contusion model respiratory function diaphragmatic activity phrenic motoneurons neuroinflammation cytokines tumor necrosis factor immune cells microglia thema EDItEUR::M Medicine and Nursing thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences |
| url | ONIX_20230105_9783036558882_10 |