Micro/Nanofluidic and Lab-on-a-Chip Devices for Biomedical Applications
Recently, microfluidic, nanofluidic and lab-on-a-chip devices have gained particular attention in biomedical applications. Due to their advantages, such as miniaturization, versatility, ease of use, cost-effectiveness, and the potential to replace animal models for drug development and testing, thes...
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| Formaat: | Online |
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| Taal: | Engels |
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MDPI - Multidisciplinary Digital Publishing Institute
2023
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| Online toegang: | ONIX_20230105_9783036561004_104 |
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| _version_ | 1869530542042513408 |
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| collection | Directory of Open Access Books |
| description | Recently, microfluidic, nanofluidic and lab-on-a-chip devices have gained particular attention in biomedical applications. Due to their advantages, such as miniaturization, versatility, ease of use, cost-effectiveness, and the potential to replace animal models for drug development and testing, these devices hold tremendous potential to revolutionize the research of more effective treatments for several diseases that threaten human life. With integrated biosensors, these devices allow the development and design of micro- and nanoparticles to be studied in detail, modelling human physiology, investigating the molecular and cellular mechanisms underlying disease formation and progression, and gaining insights into the performance and long-term effects of responsive drug delivery nanocarriers. This Special Issue gathered research papers, and review articles focusing on novel microfluidic, nanofluidic and lab-on-a-chip devices for biomedical applications, addressing all steps related to fabrication, biosensor integration and development, characterization, numerical simulations and validation of the devices, optimization and, the translation of these devices from research labs to industry settings. |
| format | Online |
| id | doab-20.500.12854ir-95875 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2023 |
| publishDateRange | 2023 |
| publishDateSort | 2023 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-958752024-03-31T13:10:14Z Micro/Nanofluidic and Lab-on-a-Chip Devices for Biomedical Applications Carvalho, Violeta Teixeira, Senhorinha de Fátima Capela Fortunas Ribeiro, João protein biomarker microarray microfluidic cassette multiplex measurement immunoassay point-of-care testing microfluidic device small intestine ex vivo histology embedded resin sectioning peptide biosensor lab-on-a-chip label-free detection peptide aptamers protein biomarkers microfluidic biochip troponin T computational simulations drug discovery organ-on-a-chip microfluidic devices preclinical models numerical simulations automation non-enzymatic DNA amplification L-DNA microfluidic fluorescence paper microfluidics sweat sensing hydrogels lactate osmotic pumping evaporation capillary wicking biochemical assay microfluidics cell trap RBC evolutionary algorithm generative design artificial intelligence organ-on-chip liver-on-chip liver disease multi-level microfluidic device live cell imaging long-term microscopy imaging focus drifting immersion oil viscosity bacterial population dynamics single-cell studies E. coli mother machine computational fluid dynamics cancer-on-chip xenograft colorectal cancer pharmacodynamics pharmacokinetics drug efficacy oxaliplatin microfabrication microphysiological system biophysical stimuli biochemical stimuli in vitro cell culture cortical neurons hippocampal neurons electrical stimulation Micro-Electrode Arrays engineered neuronal networks polydimethylsiloxane microchannels in vivo micro bioreactor additive manufacturing poly-(ethylene glycol)-diacrylate biocompatibility COVID-19 diagnosis image analysis PCR SARS-CoV-2 n/a thema EDItEUR::M Medicine and Nursing Recently, microfluidic, nanofluidic and lab-on-a-chip devices have gained particular attention in biomedical applications. Due to their advantages, such as miniaturization, versatility, ease of use, cost-effectiveness, and the potential to replace animal models for drug development and testing, these devices hold tremendous potential to revolutionize the research of more effective treatments for several diseases that threaten human life. With integrated biosensors, these devices allow the development and design of micro- and nanoparticles to be studied in detail, modelling human physiology, investigating the molecular and cellular mechanisms underlying disease formation and progression, and gaining insights into the performance and long-term effects of responsive drug delivery nanocarriers. This Special Issue gathered research papers, and review articles focusing on novel microfluidic, nanofluidic and lab-on-a-chip devices for biomedical applications, addressing all steps related to fabrication, biosensor integration and development, characterization, numerical simulations and validation of the devices, optimization and, the translation of these devices from research labs to industry settings. 2023-01-05T12:36:39Z 2023-01-05T12:36:39Z 2022 book ONIX_20230105_9783036561004_104 9783036561004 9783036560991 https://directory.doabooks.org/handle/20.500.12854/95875 eng image/jpeg Attribution 4.0 International https://mdpi.com/books/pdfview/book/6532 https://mdpi.com/books/pdfview/book/6532 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-0365-6099-1 10.3390/books978-3-0365-6099-1 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783036561004 9783036560991 232 Basel open access |
| spellingShingle | protein biomarker microarray microfluidic cassette multiplex measurement immunoassay point-of-care testing microfluidic device small intestine ex vivo histology embedded resin sectioning peptide biosensor lab-on-a-chip label-free detection peptide aptamers protein biomarkers microfluidic biochip troponin T computational simulations drug discovery organ-on-a-chip microfluidic devices preclinical models numerical simulations automation non-enzymatic DNA amplification L-DNA microfluidic fluorescence paper microfluidics sweat sensing hydrogels lactate osmotic pumping evaporation capillary wicking biochemical assay microfluidics cell trap RBC evolutionary algorithm generative design artificial intelligence organ-on-chip liver-on-chip liver disease multi-level microfluidic device live cell imaging long-term microscopy imaging focus drifting immersion oil viscosity bacterial population dynamics single-cell studies E. coli mother machine computational fluid dynamics cancer-on-chip xenograft colorectal cancer pharmacodynamics pharmacokinetics drug efficacy oxaliplatin microfabrication microphysiological system biophysical stimuli biochemical stimuli in vitro cell culture cortical neurons hippocampal neurons electrical stimulation Micro-Electrode Arrays engineered neuronal networks polydimethylsiloxane microchannels in vivo micro bioreactor additive manufacturing poly-(ethylene glycol)-diacrylate biocompatibility COVID-19 diagnosis image analysis PCR SARS-CoV-2 n/a thema EDItEUR::M Medicine and Nursing Micro/Nanofluidic and Lab-on-a-Chip Devices for Biomedical Applications |
| title | Micro/Nanofluidic and Lab-on-a-Chip Devices for Biomedical Applications |
| title_full | Micro/Nanofluidic and Lab-on-a-Chip Devices for Biomedical Applications |
| title_fullStr | Micro/Nanofluidic and Lab-on-a-Chip Devices for Biomedical Applications |
| title_full_unstemmed | Micro/Nanofluidic and Lab-on-a-Chip Devices for Biomedical Applications |
| title_short | Micro/Nanofluidic and Lab-on-a-Chip Devices for Biomedical Applications |
| title_sort | micro nanofluidic and lab on a chip devices for biomedical applications |
| topic | protein biomarker microarray microfluidic cassette multiplex measurement immunoassay point-of-care testing microfluidic device small intestine ex vivo histology embedded resin sectioning peptide biosensor lab-on-a-chip label-free detection peptide aptamers protein biomarkers microfluidic biochip troponin T computational simulations drug discovery organ-on-a-chip microfluidic devices preclinical models numerical simulations automation non-enzymatic DNA amplification L-DNA microfluidic fluorescence paper microfluidics sweat sensing hydrogels lactate osmotic pumping evaporation capillary wicking biochemical assay microfluidics cell trap RBC evolutionary algorithm generative design artificial intelligence organ-on-chip liver-on-chip liver disease multi-level microfluidic device live cell imaging long-term microscopy imaging focus drifting immersion oil viscosity bacterial population dynamics single-cell studies E. coli mother machine computational fluid dynamics cancer-on-chip xenograft colorectal cancer pharmacodynamics pharmacokinetics drug efficacy oxaliplatin microfabrication microphysiological system biophysical stimuli biochemical stimuli in vitro cell culture cortical neurons hippocampal neurons electrical stimulation Micro-Electrode Arrays engineered neuronal networks polydimethylsiloxane microchannels in vivo micro bioreactor additive manufacturing poly-(ethylene glycol)-diacrylate biocompatibility COVID-19 diagnosis image analysis PCR SARS-CoV-2 n/a thema EDItEUR::M Medicine and Nursing |
| topic_facet | protein biomarker microarray microfluidic cassette multiplex measurement immunoassay point-of-care testing microfluidic device small intestine ex vivo histology embedded resin sectioning peptide biosensor lab-on-a-chip label-free detection peptide aptamers protein biomarkers microfluidic biochip troponin T computational simulations drug discovery organ-on-a-chip microfluidic devices preclinical models numerical simulations automation non-enzymatic DNA amplification L-DNA microfluidic fluorescence paper microfluidics sweat sensing hydrogels lactate osmotic pumping evaporation capillary wicking biochemical assay microfluidics cell trap RBC evolutionary algorithm generative design artificial intelligence organ-on-chip liver-on-chip liver disease multi-level microfluidic device live cell imaging long-term microscopy imaging focus drifting immersion oil viscosity bacterial population dynamics single-cell studies E. coli mother machine computational fluid dynamics cancer-on-chip xenograft colorectal cancer pharmacodynamics pharmacokinetics drug efficacy oxaliplatin microfabrication microphysiological system biophysical stimuli biochemical stimuli in vitro cell culture cortical neurons hippocampal neurons electrical stimulation Micro-Electrode Arrays engineered neuronal networks polydimethylsiloxane microchannels in vivo micro bioreactor additive manufacturing poly-(ethylene glycol)-diacrylate biocompatibility COVID-19 diagnosis image analysis PCR SARS-CoV-2 n/a thema EDItEUR::M Medicine and Nursing |
| url | ONIX_20230105_9783036561004_104 |