Chapter 4 Obesity Is a Disease
Obesity is a subcortical brain disease characterised by the pathognomonic symptoms of excessive hunger and/or reduced satiation after a meal. Distinct subtypes of obesity are recognised, although the rising incidence of polygenic obesity resulting from incompletely elucidated gene-environment intera...
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Springer Nature
2023
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| Διαθέσιμο Online: | https://library.oapen.org/handle/20.500.12657/60591 |
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| _version_ | 1869525876336492544 |
|---|---|
| author | Martin, William P. Le Roux, Carel |
| author_browse | Le Roux, Carel Martin, William P. |
| author_facet | Martin, William P. Le Roux, Carel |
| author_sort | Martin, William P. |
| collection | Directory of Open Access Books |
| description | Obesity is a subcortical brain disease characterised by the pathognomonic symptoms of excessive hunger and/or reduced satiation after a meal. Distinct subtypes of obesity are recognised, although the rising incidence of polygenic obesity resulting from incompletely elucidated gene-environment interactions is of greatest public health concern. Obesity complications are well documented; their reversal with sustained intentional weight loss is a reason for optimism and motivation to seek treatments targeting pathophysiological mechanisms of obesity. Although lifestyle modification to achieve net energy deficit represents an important facet of obesity management, it is imperative to remember that hypothalamic dysfunction underpins this dysregulated state of energy metabolism and that solely appealing to patients’ cerebral cortices through motivational strategies will ultimately prove futile for many. Most patients will regain all the weight that they have lost if the treatment strategy does not make them less hungry and/or more satisfied with smaller meals (Dombrowski et al. 2014). Instead, we must expand our understanding of the pathophysiology of obesity and target our treatments to correct the subcortical brain disturbances which perpetuate aberrant feeding behaviours. Until our clinical tools improve, we can serve our patients better by recognising obesity as a disease and treating it with the same strategies and compassion we apply to all other chronic and disabling diseases. |
| format | Online |
| id | doab-20.500.12854ir-95973 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2023 |
| publishDateRange | 2023 |
| publishDateSort | 2023 |
| publisher | Springer Nature |
| publisherStr | Springer Nature |
| record_format | ojs |
| spelling | doab-20.500.12854ir-959732025-07-17T12:15:50Z Chapter 4 Obesity Is a Disease Martin, William P. Le Roux, Carel Obesity; disease thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders Obesity is a subcortical brain disease characterised by the pathognomonic symptoms of excessive hunger and/or reduced satiation after a meal. Distinct subtypes of obesity are recognised, although the rising incidence of polygenic obesity resulting from incompletely elucidated gene-environment interactions is of greatest public health concern. Obesity complications are well documented; their reversal with sustained intentional weight loss is a reason for optimism and motivation to seek treatments targeting pathophysiological mechanisms of obesity. Although lifestyle modification to achieve net energy deficit represents an important facet of obesity management, it is imperative to remember that hypothalamic dysfunction underpins this dysregulated state of energy metabolism and that solely appealing to patients’ cerebral cortices through motivational strategies will ultimately prove futile for many. Most patients will regain all the weight that they have lost if the treatment strategy does not make them less hungry and/or more satisfied with smaller meals (Dombrowski et al. 2014). Instead, we must expand our understanding of the pathophysiology of obesity and target our treatments to correct the subcortical brain disturbances which perpetuate aberrant feeding behaviours. Until our clinical tools improve, we can serve our patients better by recognising obesity as a disease and treating it with the same strategies and compassion we apply to all other chronic and disabling diseases. 2023-01-11T04:00:49Z 2023-01-11T04:00:49Z 2023-01-10T12:56:48Z 2022 chapter https://library.oapen.org/handle/20.500.12657/60591 9783030833985 https://directory.doabooks.org/handle/20.500.12854/95973 eng open access image/jpeg image/jpeg image/jpeg Attribution 4.0 International Attribution 4.0 International Attribution 4.0 International https://library.oapen.org/bitstream/20.500.12657/60591/1/Bookshelf_NBK586009%20%281%29.pdf https://library.oapen.org/bitstream/20.500.12657/60591/1/Bookshelf_NBK586009%20%281%29.pdf https://library.oapen.org/bitstream/20.500.12657/60591/1/Bookshelf_NBK586009%20%281%29.pdf Springer Nature 10.1007/978-3-030-83399-2_4 10.1007/978-3-030-83399-2_4 9fa3421d-f917-4153-b9ab-fc337c396b5a Bariatric Surgery in Clinical Practice Wellcome Trust d859fbd3-d884-4090-a0ec-baf821c9abfd 9783030833985 Wellcome 6 open access |
| spellingShingle | Obesity; disease thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders Martin, William P. Le Roux, Carel Chapter 4 Obesity Is a Disease |
| title | Chapter 4 Obesity Is a Disease |
| title_full | Chapter 4 Obesity Is a Disease |
| title_fullStr | Chapter 4 Obesity Is a Disease |
| title_full_unstemmed | Chapter 4 Obesity Is a Disease |
| title_short | Chapter 4 Obesity Is a Disease |
| title_sort | chapter 4 obesity is a disease |
| topic | Obesity; disease thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders |
| topic_facet | Obesity; disease thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders |
| url | https://library.oapen.org/handle/20.500.12657/60591 |
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