Molecular Mechanism and Application of Somatic Cell Cloning in Mammals
The primary objective of this book is to provide the current status of and new data on the molecular mechanisms affecting the efficacy of somatic cell cloning, but also insightful interpretations of the topical and coming trends in the exploration of genomic, epigenomic, transcriptomic and proteomic...
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| Định dạng: | Online |
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| Ngôn ngữ: | Tiếng Anh |
| Được phát hành: |
MDPI - Multidisciplinary Digital Publishing Institute
2023
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| Những chủ đề: | |
| Truy cập trực tuyến: | ONIX_20230202_9783036559667_18 |
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| _version_ | 1869520088933072896 |
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| collection | Directory of Open Access Books |
| description | The primary objective of this book is to provide the current status of and new data on the molecular mechanisms affecting the efficacy of somatic cell cloning, but also insightful interpretations of the topical and coming trends in the exploration of genomic, epigenomic, transcriptomic and proteomic profiles for nuclear donor cells, nuclear recipient oocytes and SCNT-derived embryos. Comprehensively deciphering the crucial molecular scenarios responsible for inter-genomic, inter-epigenomic, inter-transcriptomic and inter-proteomic communication within the framework of the aforementioned scenarios might be a milestone giving rise to the enhancements in the extra- and intracorporeal epigenetic reprogrammabilities of donor cell nuclei in nuclear-transferred oocytes, embryos, conceptuses and neonates. In turn, this might allow us to use SCNT-mediated ARTs in such research fields as biotechnology, transgenics, medicine, and biopharmacology, as well as scientific efforts targeted at designing the in vitro and in vivo models of molecular and epigenomic landscapes specific for inheritable and acquired disorders in humans and other mammalian species. |
| format | Online |
| id | doab-20.500.12854ir-96617 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2023 |
| publishDateRange | 2023 |
| publishDateSort | 2023 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-966172024-03-28T03:33:29Z Molecular Mechanism and Application of Somatic Cell Cloning in Mammals Samiec, Marcin Skrzyszowska, Maria cloned mammalian embryo SCNT-derived progeny mtDNA nuclear–mitochondrial interaction epigenetic reprogrammability telomere shortening/attrition domestic goat somatic cell cloning SCNT-derived embryo genetically engineered specimen gene targeting genome editing biopharmacy biomedicine nutri-biotechnology genetically modified pig epidermal keratinocyte human α-1,2-fucosyltransferase human α-galactosidase A Galα1→3Gal epitope pig ovary putative stem cells nandrolone boldenone neoplastic transformation cloned dog brachygnathia inferior whole-genome sequencing Wnt signaling pathway equine dermal fibroblast cell sarcoid nucleofection oncogenic/neoplastic transformation RNA-Seq NGS transcriptome oocyte cumulus cells 3D in vitro maturation endocrine-active compounds molecular quality apoptotic cell death mitochondria mitophagy domestic horse dermal tissue molecular pathway ECM remodeling cell adhesion procancerous tumorigenesis RNA-seq swine trichostatin A epigenetic transformation ex vivo model tri-genetically modified ACFC line HLA-E rhα-Gal A rhα1,2-FT α-Gal antigenic determinant porcine skin xenograft equine chondrocytes 5-AZA-dc and TSA epigenetic modifiers n/a thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences The primary objective of this book is to provide the current status of and new data on the molecular mechanisms affecting the efficacy of somatic cell cloning, but also insightful interpretations of the topical and coming trends in the exploration of genomic, epigenomic, transcriptomic and proteomic profiles for nuclear donor cells, nuclear recipient oocytes and SCNT-derived embryos. Comprehensively deciphering the crucial molecular scenarios responsible for inter-genomic, inter-epigenomic, inter-transcriptomic and inter-proteomic communication within the framework of the aforementioned scenarios might be a milestone giving rise to the enhancements in the extra- and intracorporeal epigenetic reprogrammabilities of donor cell nuclei in nuclear-transferred oocytes, embryos, conceptuses and neonates. In turn, this might allow us to use SCNT-mediated ARTs in such research fields as biotechnology, transgenics, medicine, and biopharmacology, as well as scientific efforts targeted at designing the in vitro and in vivo models of molecular and epigenomic landscapes specific for inheritable and acquired disorders in humans and other mammalian species. 2023-02-02T16:24:20Z 2023-02-02T16:24:20Z 2023 book ONIX_20230202_9783036559667_18 9783036559667 9783036559650 https://directory.doabooks.org/handle/20.500.12854/96617 eng image/jpeg Attribution 4.0 International https://mdpi.com/books/pdfview/book/6562 https://mdpi.com/books/pdfview/book/6562 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-0365-5965-0 10.3390/books978-3-0365-5965-0 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783036559667 9783036559650 244 Basel open access |
| spellingShingle | cloned mammalian embryo SCNT-derived progeny mtDNA nuclear–mitochondrial interaction epigenetic reprogrammability telomere shortening/attrition domestic goat somatic cell cloning SCNT-derived embryo genetically engineered specimen gene targeting genome editing biopharmacy biomedicine nutri-biotechnology genetically modified pig epidermal keratinocyte human α-1,2-fucosyltransferase human α-galactosidase A Galα1→3Gal epitope pig ovary putative stem cells nandrolone boldenone neoplastic transformation cloned dog brachygnathia inferior whole-genome sequencing Wnt signaling pathway equine dermal fibroblast cell sarcoid nucleofection oncogenic/neoplastic transformation RNA-Seq NGS transcriptome oocyte cumulus cells 3D in vitro maturation endocrine-active compounds molecular quality apoptotic cell death mitochondria mitophagy domestic horse dermal tissue molecular pathway ECM remodeling cell adhesion procancerous tumorigenesis RNA-seq swine trichostatin A epigenetic transformation ex vivo model tri-genetically modified ACFC line HLA-E rhα-Gal A rhα1,2-FT α-Gal antigenic determinant porcine skin xenograft equine chondrocytes 5-AZA-dc and TSA epigenetic modifiers n/a thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences Molecular Mechanism and Application of Somatic Cell Cloning in Mammals |
| title | Molecular Mechanism and Application of Somatic Cell Cloning in Mammals |
| title_full | Molecular Mechanism and Application of Somatic Cell Cloning in Mammals |
| title_fullStr | Molecular Mechanism and Application of Somatic Cell Cloning in Mammals |
| title_full_unstemmed | Molecular Mechanism and Application of Somatic Cell Cloning in Mammals |
| title_short | Molecular Mechanism and Application of Somatic Cell Cloning in Mammals |
| title_sort | molecular mechanism and application of somatic cell cloning in mammals |
| topic | cloned mammalian embryo SCNT-derived progeny mtDNA nuclear–mitochondrial interaction epigenetic reprogrammability telomere shortening/attrition domestic goat somatic cell cloning SCNT-derived embryo genetically engineered specimen gene targeting genome editing biopharmacy biomedicine nutri-biotechnology genetically modified pig epidermal keratinocyte human α-1,2-fucosyltransferase human α-galactosidase A Galα1→3Gal epitope pig ovary putative stem cells nandrolone boldenone neoplastic transformation cloned dog brachygnathia inferior whole-genome sequencing Wnt signaling pathway equine dermal fibroblast cell sarcoid nucleofection oncogenic/neoplastic transformation RNA-Seq NGS transcriptome oocyte cumulus cells 3D in vitro maturation endocrine-active compounds molecular quality apoptotic cell death mitochondria mitophagy domestic horse dermal tissue molecular pathway ECM remodeling cell adhesion procancerous tumorigenesis RNA-seq swine trichostatin A epigenetic transformation ex vivo model tri-genetically modified ACFC line HLA-E rhα-Gal A rhα1,2-FT α-Gal antigenic determinant porcine skin xenograft equine chondrocytes 5-AZA-dc and TSA epigenetic modifiers n/a thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences |
| topic_facet | cloned mammalian embryo SCNT-derived progeny mtDNA nuclear–mitochondrial interaction epigenetic reprogrammability telomere shortening/attrition domestic goat somatic cell cloning SCNT-derived embryo genetically engineered specimen gene targeting genome editing biopharmacy biomedicine nutri-biotechnology genetically modified pig epidermal keratinocyte human α-1,2-fucosyltransferase human α-galactosidase A Galα1→3Gal epitope pig ovary putative stem cells nandrolone boldenone neoplastic transformation cloned dog brachygnathia inferior whole-genome sequencing Wnt signaling pathway equine dermal fibroblast cell sarcoid nucleofection oncogenic/neoplastic transformation RNA-Seq NGS transcriptome oocyte cumulus cells 3D in vitro maturation endocrine-active compounds molecular quality apoptotic cell death mitochondria mitophagy domestic horse dermal tissue molecular pathway ECM remodeling cell adhesion procancerous tumorigenesis RNA-seq swine trichostatin A epigenetic transformation ex vivo model tri-genetically modified ACFC line HLA-E rhα-Gal A rhα1,2-FT α-Gal antigenic determinant porcine skin xenograft equine chondrocytes 5-AZA-dc and TSA epigenetic modifiers n/a thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences |
| url | ONIX_20230202_9783036559667_18 |