Personalized Medicine for Parkinson's Disease
Personalized medicine for Parkinson’s disease is a growing and emerging concept in light of recent recognition that Parkinson’s is a syndromic condition affecting multiple neurotransmitter systems, as well as brain and extracranial structures. The clinical expression is, thus, heterogeneous, and pre...
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| Materialtyp: | Online |
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| Språk: | engelska |
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MDPI - Multidisciplinary Digital Publishing Institute
2023
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| Länkar: | ONIX_20230202_9783036562124_37 |
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| _version_ | 1869515431431110656 |
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| collection | Directory of Open Access Books |
| description | Personalized medicine for Parkinson’s disease is a growing and emerging concept in light of recent recognition that Parkinson’s is a syndromic condition affecting multiple neurotransmitter systems, as well as brain and extracranial structures. The clinical expression is, thus, heterogeneous, and presentation age can range from the 30s to the 90s, with PD in older patients being associated with significant neuropathological comorbidity as well, involving not just misfolded alpha synuclein deposition but also amyloid and tau. Traditional and largely guideline-driven “one size fits all” management strategies adopted in clinical practice are, therefore, often inadequate in holistic management of a patient, particularly when aspects of motor and nonmotor symptoms are taken into consideration. In this supplement of JPM, we present a selection of papers which address several possible strands of personalized medicine in PD, ranging from genomic precision medicine to digital “checklists” to ensure delivery of holistic personalized medicine involving nonpharmacological strategies, as well. We are soliciting any papers addressing biomarkers, genetics and pharmacogenetics, treatment or complementary therapies for personalized or individualized treatment for PD. |
| format | Online |
| id | doab-20.500.12854ir-96636 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2023 |
| publishDateRange | 2023 |
| publishDateSort | 2023 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-966362024-03-31T13:08:17Z Personalized Medicine for Parkinson's Disease Titova, Nataliya Chaudhuri, K. Ray Parkinson’s disease movement disorders periodontitis periodontal disease hematologic tests Vitamin D oral health Parkinson’s Disease cognition GABAergic signaling cerebellum MRS response inhibition non-motor symptoms carer stress older persons with Parkinson’s disease education lifestyle behaviours diet cross-sectional population study neurological disorders precision medicine genetics clinical trials Parkinson’s disease (PD) cognitive rehabilitation intervention deep brain stimulation levodopa-carbidopa intestinal gel apomorphine radiofrequency focused ultrasound induced pluripotent stem cells cell therapy gene therapy personalized medicine advanced Parkinson’s disease (APD) apomorphine subcutaneous infusion therapy pain intrajejunal levodopa motor and non-motor symptoms PKG (KinetiGrap) rehabilitation device-aided therapies personalised medicine Alzheimer’s disease clinical trial impulsive-compulsive disorders (ICD) dopaminergic therapy genetic markers pharmacogenetic polymorphisms insomnia sleep quality assessment young onset Parkinson’s (YOPD) Emiratis expatriate genetic epigenetics societal impact device aided therapies quality of life non motor symptoms n/a thema EDItEUR::M Medicine and Nursing thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKJ Neurology and clinical neurophysiology Personalized medicine for Parkinson’s disease is a growing and emerging concept in light of recent recognition that Parkinson’s is a syndromic condition affecting multiple neurotransmitter systems, as well as brain and extracranial structures. The clinical expression is, thus, heterogeneous, and presentation age can range from the 30s to the 90s, with PD in older patients being associated with significant neuropathological comorbidity as well, involving not just misfolded alpha synuclein deposition but also amyloid and tau. Traditional and largely guideline-driven “one size fits all” management strategies adopted in clinical practice are, therefore, often inadequate in holistic management of a patient, particularly when aspects of motor and nonmotor symptoms are taken into consideration. In this supplement of JPM, we present a selection of papers which address several possible strands of personalized medicine in PD, ranging from genomic precision medicine to digital “checklists” to ensure delivery of holistic personalized medicine involving nonpharmacological strategies, as well. We are soliciting any papers addressing biomarkers, genetics and pharmacogenetics, treatment or complementary therapies for personalized or individualized treatment for PD. 2023-02-02T16:28:24Z 2023-02-02T16:28:24Z 2023 book ONIX_20230202_9783036562124_37 9783036562124 9783036562117 https://directory.doabooks.org/handle/20.500.12854/96636 eng image/jpeg Attribution 4.0 International https://mdpi.com/books/pdfview/book/6581 https://mdpi.com/books/pdfview/book/6581 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-0365-6211-7 10.3390/books978-3-0365-6211-7 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783036562124 9783036562117 214 Basel open access |
| spellingShingle | Parkinson’s disease movement disorders periodontitis periodontal disease hematologic tests Vitamin D oral health Parkinson’s Disease cognition GABAergic signaling cerebellum MRS response inhibition non-motor symptoms carer stress older persons with Parkinson’s disease education lifestyle behaviours diet cross-sectional population study neurological disorders precision medicine genetics clinical trials Parkinson’s disease (PD) cognitive rehabilitation intervention deep brain stimulation levodopa-carbidopa intestinal gel apomorphine radiofrequency focused ultrasound induced pluripotent stem cells cell therapy gene therapy personalized medicine advanced Parkinson’s disease (APD) apomorphine subcutaneous infusion therapy pain intrajejunal levodopa motor and non-motor symptoms PKG (KinetiGrap) rehabilitation device-aided therapies personalised medicine Alzheimer’s disease clinical trial impulsive-compulsive disorders (ICD) dopaminergic therapy genetic markers pharmacogenetic polymorphisms insomnia sleep quality assessment young onset Parkinson’s (YOPD) Emiratis expatriate genetic epigenetics societal impact device aided therapies quality of life non motor symptoms n/a thema EDItEUR::M Medicine and Nursing thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKJ Neurology and clinical neurophysiology Personalized Medicine for Parkinson's Disease |
| title | Personalized Medicine for Parkinson's Disease |
| title_full | Personalized Medicine for Parkinson's Disease |
| title_fullStr | Personalized Medicine for Parkinson's Disease |
| title_full_unstemmed | Personalized Medicine for Parkinson's Disease |
| title_short | Personalized Medicine for Parkinson's Disease |
| title_sort | personalized medicine for parkinson s disease |
| topic | Parkinson’s disease movement disorders periodontitis periodontal disease hematologic tests Vitamin D oral health Parkinson’s Disease cognition GABAergic signaling cerebellum MRS response inhibition non-motor symptoms carer stress older persons with Parkinson’s disease education lifestyle behaviours diet cross-sectional population study neurological disorders precision medicine genetics clinical trials Parkinson’s disease (PD) cognitive rehabilitation intervention deep brain stimulation levodopa-carbidopa intestinal gel apomorphine radiofrequency focused ultrasound induced pluripotent stem cells cell therapy gene therapy personalized medicine advanced Parkinson’s disease (APD) apomorphine subcutaneous infusion therapy pain intrajejunal levodopa motor and non-motor symptoms PKG (KinetiGrap) rehabilitation device-aided therapies personalised medicine Alzheimer’s disease clinical trial impulsive-compulsive disorders (ICD) dopaminergic therapy genetic markers pharmacogenetic polymorphisms insomnia sleep quality assessment young onset Parkinson’s (YOPD) Emiratis expatriate genetic epigenetics societal impact device aided therapies quality of life non motor symptoms n/a thema EDItEUR::M Medicine and Nursing thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKJ Neurology and clinical neurophysiology |
| topic_facet | Parkinson’s disease movement disorders periodontitis periodontal disease hematologic tests Vitamin D oral health Parkinson’s Disease cognition GABAergic signaling cerebellum MRS response inhibition non-motor symptoms carer stress older persons with Parkinson’s disease education lifestyle behaviours diet cross-sectional population study neurological disorders precision medicine genetics clinical trials Parkinson’s disease (PD) cognitive rehabilitation intervention deep brain stimulation levodopa-carbidopa intestinal gel apomorphine radiofrequency focused ultrasound induced pluripotent stem cells cell therapy gene therapy personalized medicine advanced Parkinson’s disease (APD) apomorphine subcutaneous infusion therapy pain intrajejunal levodopa motor and non-motor symptoms PKG (KinetiGrap) rehabilitation device-aided therapies personalised medicine Alzheimer’s disease clinical trial impulsive-compulsive disorders (ICD) dopaminergic therapy genetic markers pharmacogenetic polymorphisms insomnia sleep quality assessment young onset Parkinson’s (YOPD) Emiratis expatriate genetic epigenetics societal impact device aided therapies quality of life non motor symptoms n/a thema EDItEUR::M Medicine and Nursing thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKJ Neurology and clinical neurophysiology |
| url | ONIX_20230202_9783036562124_37 |