Induced Impairment of Neurogenesis and Brain Diseases
The impairment of neurogenesis may be induced after pre- and post-natal chemical and biological toxin, alcohol, or radiation exposure, drug treatment, hormone imbalances, stress, pain, hypoxia, brain trauma, malnutrition, and aging. It also occurs as a result of genetic disorders such as Down syndro...
-д хадгалсан:
| Формат: | Online |
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| Хэл сонгох: | англи |
| Хэвлэсэн: |
MDPI - Multidisciplinary Digital Publishing Institute
2023
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| Нөхцлүүд: | |
| Онлайн хандалт: | ONIX_20230202_9783036562148_73 |
| Шошгууд: |
Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!
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| _version_ | 1869519587297460224 |
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| collection | Directory of Open Access Books |
| description | The impairment of neurogenesis may be induced after pre- and post-natal chemical and biological toxin, alcohol, or radiation exposure, drug treatment, hormone imbalances, stress, pain, hypoxia, brain trauma, malnutrition, and aging. It also occurs as a result of genetic disorders such as Down syndrome (DS), autism, fragile X syndrome (FXS), neurological disorders including Alzheimer's disease (AD), Parkinson's disease (PD) epilepsy, and Huntington's disease (HD), and neuropsychiatric disorders such as depression and schizophrenia; however, the causal relationship between the impairment of neurogenesis and neurological and neuropsychiatric disorders remains unknown. In this Special Issue, entitled “Induced Impairment of Neurogenesis and Brain Diseases”, original animal or cell experimental research and review papers were combined to discuss different causes of the impairment of neurogenesis, relevant neurobehavioral changes, molecular mechanisms, and therapeutic approaches. The aim is to update researchers and clinicians about the complexity of the development of the impairment of neurogenesis, the importance of the involvement of the impairment of neurogenesis in neurological and neuropsychiatric disorders, and to provide some clues for designing novel therapeutic approaches by targeting the impairment of neurogenesis to effectively prevent or treat different genetic, neurological, and neuropsychological disorders. |
| format | Online |
| id | doab-20.500.12854ir-96672 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2023 |
| publishDateRange | 2023 |
| publishDateSort | 2023 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-966722024-03-31T13:08:31Z Induced Impairment of Neurogenesis and Brain Diseases Tang, FengRu neurogenesis TGF-β smad depression stress complementary and alternative medicines natural products peripheral nerve injury nerve repair nerve regeneration functional recovery neuroinflammation microglia TSPO mitochondria cytokines antioxidants γ-irradiation miR-34a-5p tia1 N6-methyladenosine Mettl3 Mettl14 Fto Ythdf1 neurodevelopment neurodegeneration SMG6 NMD neurodevelopmental syndromes ionizing radiation aging brain oxidative stress mitochondrial dysfunction DNA damage gut microbiota gut-brain axis adult neurogenesis ageing neural stem cells nutrients polyphenols TRIM32 excitatory-inhibitory imbalance cortex development ASD NPCs GHSR1 ghrelin hypoxia transcription factors progenitor cells adult hippocampal neurogenesis Alzheimer’s disease Aβ peptide DNA methylation gene expression NXN CNTNAP1 SEPT5-GP1BB TBX5 miR-146b cognition anxiety astrocytes neuronal development Gdnf microcephaly MCPH1 central domain brain development gonad development thema EDItEUR::M Medicine and Nursing thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences The impairment of neurogenesis may be induced after pre- and post-natal chemical and biological toxin, alcohol, or radiation exposure, drug treatment, hormone imbalances, stress, pain, hypoxia, brain trauma, malnutrition, and aging. It also occurs as a result of genetic disorders such as Down syndrome (DS), autism, fragile X syndrome (FXS), neurological disorders including Alzheimer's disease (AD), Parkinson's disease (PD) epilepsy, and Huntington's disease (HD), and neuropsychiatric disorders such as depression and schizophrenia; however, the causal relationship between the impairment of neurogenesis and neurological and neuropsychiatric disorders remains unknown. In this Special Issue, entitled “Induced Impairment of Neurogenesis and Brain Diseases”, original animal or cell experimental research and review papers were combined to discuss different causes of the impairment of neurogenesis, relevant neurobehavioral changes, molecular mechanisms, and therapeutic approaches. The aim is to update researchers and clinicians about the complexity of the development of the impairment of neurogenesis, the importance of the involvement of the impairment of neurogenesis in neurological and neuropsychiatric disorders, and to provide some clues for designing novel therapeutic approaches by targeting the impairment of neurogenesis to effectively prevent or treat different genetic, neurological, and neuropsychological disorders. 2023-02-02T16:34:04Z 2023-02-02T16:34:04Z 2023 book ONIX_20230202_9783036562148_73 9783036562148 9783036562131 https://directory.doabooks.org/handle/20.500.12854/96672 eng image/jpeg Attribution 4.0 International https://mdpi.com/books/pdfview/book/6617 https://mdpi.com/books/pdfview/book/6617 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-0365-6213-1 10.3390/books978-3-0365-6213-1 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783036562148 9783036562131 282 Basel open access |
| spellingShingle | neurogenesis TGF-β smad depression stress complementary and alternative medicines natural products peripheral nerve injury nerve repair nerve regeneration functional recovery neuroinflammation microglia TSPO mitochondria cytokines antioxidants γ-irradiation miR-34a-5p tia1 N6-methyladenosine Mettl3 Mettl14 Fto Ythdf1 neurodevelopment neurodegeneration SMG6 NMD neurodevelopmental syndromes ionizing radiation aging brain oxidative stress mitochondrial dysfunction DNA damage gut microbiota gut-brain axis adult neurogenesis ageing neural stem cells nutrients polyphenols TRIM32 excitatory-inhibitory imbalance cortex development ASD NPCs GHSR1 ghrelin hypoxia transcription factors progenitor cells adult hippocampal neurogenesis Alzheimer’s disease Aβ peptide DNA methylation gene expression NXN CNTNAP1 SEPT5-GP1BB TBX5 miR-146b cognition anxiety astrocytes neuronal development Gdnf microcephaly MCPH1 central domain brain development gonad development thema EDItEUR::M Medicine and Nursing thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences Induced Impairment of Neurogenesis and Brain Diseases |
| title | Induced Impairment of Neurogenesis and Brain Diseases |
| title_full | Induced Impairment of Neurogenesis and Brain Diseases |
| title_fullStr | Induced Impairment of Neurogenesis and Brain Diseases |
| title_full_unstemmed | Induced Impairment of Neurogenesis and Brain Diseases |
| title_short | Induced Impairment of Neurogenesis and Brain Diseases |
| title_sort | induced impairment of neurogenesis and brain diseases |
| topic | neurogenesis TGF-β smad depression stress complementary and alternative medicines natural products peripheral nerve injury nerve repair nerve regeneration functional recovery neuroinflammation microglia TSPO mitochondria cytokines antioxidants γ-irradiation miR-34a-5p tia1 N6-methyladenosine Mettl3 Mettl14 Fto Ythdf1 neurodevelopment neurodegeneration SMG6 NMD neurodevelopmental syndromes ionizing radiation aging brain oxidative stress mitochondrial dysfunction DNA damage gut microbiota gut-brain axis adult neurogenesis ageing neural stem cells nutrients polyphenols TRIM32 excitatory-inhibitory imbalance cortex development ASD NPCs GHSR1 ghrelin hypoxia transcription factors progenitor cells adult hippocampal neurogenesis Alzheimer’s disease Aβ peptide DNA methylation gene expression NXN CNTNAP1 SEPT5-GP1BB TBX5 miR-146b cognition anxiety astrocytes neuronal development Gdnf microcephaly MCPH1 central domain brain development gonad development thema EDItEUR::M Medicine and Nursing thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences |
| topic_facet | neurogenesis TGF-β smad depression stress complementary and alternative medicines natural products peripheral nerve injury nerve repair nerve regeneration functional recovery neuroinflammation microglia TSPO mitochondria cytokines antioxidants γ-irradiation miR-34a-5p tia1 N6-methyladenosine Mettl3 Mettl14 Fto Ythdf1 neurodevelopment neurodegeneration SMG6 NMD neurodevelopmental syndromes ionizing radiation aging brain oxidative stress mitochondrial dysfunction DNA damage gut microbiota gut-brain axis adult neurogenesis ageing neural stem cells nutrients polyphenols TRIM32 excitatory-inhibitory imbalance cortex development ASD NPCs GHSR1 ghrelin hypoxia transcription factors progenitor cells adult hippocampal neurogenesis Alzheimer’s disease Aβ peptide DNA methylation gene expression NXN CNTNAP1 SEPT5-GP1BB TBX5 miR-146b cognition anxiety astrocytes neuronal development Gdnf microcephaly MCPH1 central domain brain development gonad development thema EDItEUR::M Medicine and Nursing thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences |
| url | ONIX_20230202_9783036562148_73 |