Genomic Analysis of Antibiotics Resistance in Pathogens
The emergence of antibiotic-resistant pathogens currently represents a serious threat to public health and the economy. Due to antibiotic treatments in humans and veterinary medicine, prophylactic use and environmental contamination, bacteria are today more frequently exposed to unnatural doses of a...
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| Format: | Online |
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| Language: | English |
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MDPI - Multidisciplinary Digital Publishing Institute
2023
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| Online Access: | ONIX_20230202_9783036565248_137 |
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| description | The emergence of antibiotic-resistant pathogens currently represents a serious threat to public health and the economy. Due to antibiotic treatments in humans and veterinary medicine, prophylactic use and environmental contamination, bacteria are today more frequently exposed to unnatural doses of antibiotics and their selective effect.Antibiotic resistance can be encoded on chromosomes, plasmids, or other mobile genetic elements in bacteria. It may also result from mutations that lead to changes in the affinity of antibiotics for their targets or in the ability of antibiotics to act on bacterial growth or death. Exposure of bacteria, bacterial populations, and microbial communities to antibiotics at different concentrations shapes their genomic dynamics, as does the mobilisation and spread of resistance determinants. It is, therefore, essential to understand the dynamics and mobilisation of genes encoding antibiotic resistance, in human, animal, plant, and environmental microbiomes, through genomic and metagenomic approaches and bioinformatics analyses.This Special Issue gathers research publications on the horizontal transfer of antibiotic-resistance genes, their dissemination and epidemiology, their association with bacterial virulence, between bacterial genotypes and their phenotypes, and other related research topics. |
| format | Online |
| id | doab-20.500.12854ir-96736 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2023 |
| publishDateRange | 2023 |
| publishDateSort | 2023 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-967362024-03-28T03:31:14Z Genomic Analysis of Antibiotics Resistance in Pathogens Nogueira, Teresa V. antimicrobial drug resistance pan-genome multilocus sequence typing nosocomial infections MDR P. aeruginosa titanium dioxide nanoparticles biofilm efflux pumps quorum-sensing system real-time polymerase chain reaction MDR E. coli ESBLs MBLs MAR index Francisella tularensis resazurin DipA PilD tularemia antibiotic resistance Acinetobacter baumannii colistin carbapenems multidrug resistant WGS KPC-70 Klebsiella pneumoniae ceftazidime/avibactam resistance KPC-3 ST13 KPC-variant hypermucoviscosity hypervirulence Portugal comparative genomic analysis CA-MRSA EMRSA-15 PVL-positive ST22 N. gonorrhoeae fluoroquinolone AMR ciprofloxacin Mycobacteroides abscessus tigecycline genetic determinants WhiB7 SigH RshA antimicrobial resistance hvKP K2 capsule ST14 fimbrial proteins aerobactin antibiotic resistance virulence plasmid Integrative and Conjugative Element co-selection genomics evolution S. Infantis multidrug-resistance blaCTX-M-65 fosA3 heavy-metal resistance pESI-like megaplasmid whole-genome sequencing ST213 worldwide strains genomic databases antibiotic resistance plasmids Typhimurium n/a thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSG Microbiology (non-medical) The emergence of antibiotic-resistant pathogens currently represents a serious threat to public health and the economy. Due to antibiotic treatments in humans and veterinary medicine, prophylactic use and environmental contamination, bacteria are today more frequently exposed to unnatural doses of antibiotics and their selective effect.Antibiotic resistance can be encoded on chromosomes, plasmids, or other mobile genetic elements in bacteria. It may also result from mutations that lead to changes in the affinity of antibiotics for their targets or in the ability of antibiotics to act on bacterial growth or death. Exposure of bacteria, bacterial populations, and microbial communities to antibiotics at different concentrations shapes their genomic dynamics, as does the mobilisation and spread of resistance determinants. It is, therefore, essential to understand the dynamics and mobilisation of genes encoding antibiotic resistance, in human, animal, plant, and environmental microbiomes, through genomic and metagenomic approaches and bioinformatics analyses.This Special Issue gathers research publications on the horizontal transfer of antibiotic-resistance genes, their dissemination and epidemiology, their association with bacterial virulence, between bacterial genotypes and their phenotypes, and other related research topics. 2023-02-02T16:45:27Z 2023-02-02T16:45:27Z 2023 book ONIX_20230202_9783036565248_137 9783036565248 9783036565231 https://directory.doabooks.org/handle/20.500.12854/96736 eng image/jpeg Attribution 4.0 International https://mdpi.com/books/pdfview/book/6682 https://mdpi.com/books/pdfview/book/6682 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-0365-6523-1 10.3390/books978-3-0365-6523-1 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783036565248 9783036565231 220 Basel open access |
| spellingShingle | antimicrobial drug resistance pan-genome multilocus sequence typing nosocomial infections MDR P. aeruginosa titanium dioxide nanoparticles biofilm efflux pumps quorum-sensing system real-time polymerase chain reaction MDR E. coli ESBLs MBLs MAR index Francisella tularensis resazurin DipA PilD tularemia antibiotic resistance Acinetobacter baumannii colistin carbapenems multidrug resistant WGS KPC-70 Klebsiella pneumoniae ceftazidime/avibactam resistance KPC-3 ST13 KPC-variant hypermucoviscosity hypervirulence Portugal comparative genomic analysis CA-MRSA EMRSA-15 PVL-positive ST22 N. gonorrhoeae fluoroquinolone AMR ciprofloxacin Mycobacteroides abscessus tigecycline genetic determinants WhiB7 SigH RshA antimicrobial resistance hvKP K2 capsule ST14 fimbrial proteins aerobactin antibiotic resistance virulence plasmid Integrative and Conjugative Element co-selection genomics evolution S. Infantis multidrug-resistance blaCTX-M-65 fosA3 heavy-metal resistance pESI-like megaplasmid whole-genome sequencing ST213 worldwide strains genomic databases antibiotic resistance plasmids Typhimurium n/a thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSG Microbiology (non-medical) Genomic Analysis of Antibiotics Resistance in Pathogens |
| title | Genomic Analysis of Antibiotics Resistance in Pathogens |
| title_full | Genomic Analysis of Antibiotics Resistance in Pathogens |
| title_fullStr | Genomic Analysis of Antibiotics Resistance in Pathogens |
| title_full_unstemmed | Genomic Analysis of Antibiotics Resistance in Pathogens |
| title_short | Genomic Analysis of Antibiotics Resistance in Pathogens |
| title_sort | genomic analysis of antibiotics resistance in pathogens |
| topic | antimicrobial drug resistance pan-genome multilocus sequence typing nosocomial infections MDR P. aeruginosa titanium dioxide nanoparticles biofilm efflux pumps quorum-sensing system real-time polymerase chain reaction MDR E. coli ESBLs MBLs MAR index Francisella tularensis resazurin DipA PilD tularemia antibiotic resistance Acinetobacter baumannii colistin carbapenems multidrug resistant WGS KPC-70 Klebsiella pneumoniae ceftazidime/avibactam resistance KPC-3 ST13 KPC-variant hypermucoviscosity hypervirulence Portugal comparative genomic analysis CA-MRSA EMRSA-15 PVL-positive ST22 N. gonorrhoeae fluoroquinolone AMR ciprofloxacin Mycobacteroides abscessus tigecycline genetic determinants WhiB7 SigH RshA antimicrobial resistance hvKP K2 capsule ST14 fimbrial proteins aerobactin antibiotic resistance virulence plasmid Integrative and Conjugative Element co-selection genomics evolution S. Infantis multidrug-resistance blaCTX-M-65 fosA3 heavy-metal resistance pESI-like megaplasmid whole-genome sequencing ST213 worldwide strains genomic databases antibiotic resistance plasmids Typhimurium n/a thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSG Microbiology (non-medical) |
| topic_facet | antimicrobial drug resistance pan-genome multilocus sequence typing nosocomial infections MDR P. aeruginosa titanium dioxide nanoparticles biofilm efflux pumps quorum-sensing system real-time polymerase chain reaction MDR E. coli ESBLs MBLs MAR index Francisella tularensis resazurin DipA PilD tularemia antibiotic resistance Acinetobacter baumannii colistin carbapenems multidrug resistant WGS KPC-70 Klebsiella pneumoniae ceftazidime/avibactam resistance KPC-3 ST13 KPC-variant hypermucoviscosity hypervirulence Portugal comparative genomic analysis CA-MRSA EMRSA-15 PVL-positive ST22 N. gonorrhoeae fluoroquinolone AMR ciprofloxacin Mycobacteroides abscessus tigecycline genetic determinants WhiB7 SigH RshA antimicrobial resistance hvKP K2 capsule ST14 fimbrial proteins aerobactin antibiotic resistance virulence plasmid Integrative and Conjugative Element co-selection genomics evolution S. Infantis multidrug-resistance blaCTX-M-65 fosA3 heavy-metal resistance pESI-like megaplasmid whole-genome sequencing ST213 worldwide strains genomic databases antibiotic resistance plasmids Typhimurium n/a thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSG Microbiology (non-medical) |
| url | ONIX_20230202_9783036565248_137 |