Light-Controlled Modulation and Analysis of Neuronal Functions
Contemporary research has been enriched by new directions in which light plays a key role as a tool for the modulation of cellular activity and the invasive monitoring of intracellular ions and other components. The progress in molecular biology, imaging techniques and other modern technologies has...
Zapisane w:
| Format: | Online |
|---|---|
| Język: | angielski |
| Wydane: |
MDPI - Multidisciplinary Digital Publishing Institute
2023
|
| Hasła przedmiotowe: | |
| Dostęp online: | ONIX_20230202_9783036565637_138 |
| Etykiety: |
Nie ma etykietki, Dołącz pierwszą etykiete!
|
| _version_ | 1869517106233475072 |
|---|---|
| collection | Directory of Open Access Books |
| description | Contemporary research has been enriched by new directions in which light plays a key role as a tool for the modulation of cellular activity and the invasive monitoring of intracellular ions and other components. The progress in molecular biology, imaging techniques and other modern technologies has led to the emergence of three main areas in which light is the main tool: optogenetics, photopharmacology, and optosensorics. The main advantages of these approaches are the possibilities to investigate the functions of cells; modulate the activity of ion channels, synaptic transmission and neuronal circuits; measure concentrations of ions and other cellular components; and even control the behaviour of organisms.Due to the development of these powerful molecular and genetic tools, our understanding of the mechanisms underlying the functioning of the nervous system has greatly advanced. This reprint is intended to highlight the latest advances in these areas with a primary focus on light-based analysis and control of neuronal functions. |
| format | Online |
| id | doab-20.500.12854ir-96737 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2023 |
| publishDateRange | 2023 |
| publishDateSort | 2023 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-967372024-03-28T03:33:15Z Light-Controlled Modulation and Analysis of Neuronal Functions Bregestovski, Piotr Matera, Carlo parietal association cortex fear memory c-fos calcium activity transgenic mice two-photon imaging neuromuscular junction neurotransmitter release acetylcholine nicotinic receptor calcium channel calcium transient Parkinson′s disease α-synuclein neurogenesis neural stem cell neural progenitor cell astrocyte optogenetics astrocytes hippocampal neurons patch-clamp channelrhodopsin-2 opto-α1-adrenoreceptor photopharmacology photoswitchable ligands ion channels voltage-gated ion channels ligand-gated ion channels homology modeling molecular docking molecular dynamics enhanced sampling genetically encoded biosensors optopharmacology intracellular pH intracellular chloride brain slices pH and Cl− transporters Ca2+ indicators calcium in vivo imaging place cells place fields cognitive maps ENaC phosphoinositides PIP2 optogenetic CRY2 sodium channel CoroNa Green azobenzene behavior brainwave dopamine GPCR in vivo electrophysiology photochromism photoswitch zebrafish neural plasticity tropomyosin kinase receptor B parvalbumin-positive interneurons calcium/calmodulin positive pyramidal neurons V1/visual cortex multiple regression with interaction and simple slopes analysis n/a thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences Contemporary research has been enriched by new directions in which light plays a key role as a tool for the modulation of cellular activity and the invasive monitoring of intracellular ions and other components. The progress in molecular biology, imaging techniques and other modern technologies has led to the emergence of three main areas in which light is the main tool: optogenetics, photopharmacology, and optosensorics. The main advantages of these approaches are the possibilities to investigate the functions of cells; modulate the activity of ion channels, synaptic transmission and neuronal circuits; measure concentrations of ions and other cellular components; and even control the behaviour of organisms.Due to the development of these powerful molecular and genetic tools, our understanding of the mechanisms underlying the functioning of the nervous system has greatly advanced. This reprint is intended to highlight the latest advances in these areas with a primary focus on light-based analysis and control of neuronal functions. 2023-02-02T16:45:39Z 2023-02-02T16:45:39Z 2023 book ONIX_20230202_9783036565637_138 9783036565637 9783036565620 https://directory.doabooks.org/handle/20.500.12854/96737 eng image/jpeg Attribution 4.0 International https://mdpi.com/books/pdfview/book/6683 https://mdpi.com/books/pdfview/book/6683 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-0365-6562-0 10.3390/books978-3-0365-6562-0 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783036565637 9783036565620 200 Basel open access |
| spellingShingle | parietal association cortex fear memory c-fos calcium activity transgenic mice two-photon imaging neuromuscular junction neurotransmitter release acetylcholine nicotinic receptor calcium channel calcium transient Parkinson′s disease α-synuclein neurogenesis neural stem cell neural progenitor cell astrocyte optogenetics astrocytes hippocampal neurons patch-clamp channelrhodopsin-2 opto-α1-adrenoreceptor photopharmacology photoswitchable ligands ion channels voltage-gated ion channels ligand-gated ion channels homology modeling molecular docking molecular dynamics enhanced sampling genetically encoded biosensors optopharmacology intracellular pH intracellular chloride brain slices pH and Cl− transporters Ca2+ indicators calcium in vivo imaging place cells place fields cognitive maps ENaC phosphoinositides PIP2 optogenetic CRY2 sodium channel CoroNa Green azobenzene behavior brainwave dopamine GPCR in vivo electrophysiology photochromism photoswitch zebrafish neural plasticity tropomyosin kinase receptor B parvalbumin-positive interneurons calcium/calmodulin positive pyramidal neurons V1/visual cortex multiple regression with interaction and simple slopes analysis n/a thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences Light-Controlled Modulation and Analysis of Neuronal Functions |
| title | Light-Controlled Modulation and Analysis of Neuronal Functions |
| title_full | Light-Controlled Modulation and Analysis of Neuronal Functions |
| title_fullStr | Light-Controlled Modulation and Analysis of Neuronal Functions |
| title_full_unstemmed | Light-Controlled Modulation and Analysis of Neuronal Functions |
| title_short | Light-Controlled Modulation and Analysis of Neuronal Functions |
| title_sort | light controlled modulation and analysis of neuronal functions |
| topic | parietal association cortex fear memory c-fos calcium activity transgenic mice two-photon imaging neuromuscular junction neurotransmitter release acetylcholine nicotinic receptor calcium channel calcium transient Parkinson′s disease α-synuclein neurogenesis neural stem cell neural progenitor cell astrocyte optogenetics astrocytes hippocampal neurons patch-clamp channelrhodopsin-2 opto-α1-adrenoreceptor photopharmacology photoswitchable ligands ion channels voltage-gated ion channels ligand-gated ion channels homology modeling molecular docking molecular dynamics enhanced sampling genetically encoded biosensors optopharmacology intracellular pH intracellular chloride brain slices pH and Cl− transporters Ca2+ indicators calcium in vivo imaging place cells place fields cognitive maps ENaC phosphoinositides PIP2 optogenetic CRY2 sodium channel CoroNa Green azobenzene behavior brainwave dopamine GPCR in vivo electrophysiology photochromism photoswitch zebrafish neural plasticity tropomyosin kinase receptor B parvalbumin-positive interneurons calcium/calmodulin positive pyramidal neurons V1/visual cortex multiple regression with interaction and simple slopes analysis n/a thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences |
| topic_facet | parietal association cortex fear memory c-fos calcium activity transgenic mice two-photon imaging neuromuscular junction neurotransmitter release acetylcholine nicotinic receptor calcium channel calcium transient Parkinson′s disease α-synuclein neurogenesis neural stem cell neural progenitor cell astrocyte optogenetics astrocytes hippocampal neurons patch-clamp channelrhodopsin-2 opto-α1-adrenoreceptor photopharmacology photoswitchable ligands ion channels voltage-gated ion channels ligand-gated ion channels homology modeling molecular docking molecular dynamics enhanced sampling genetically encoded biosensors optopharmacology intracellular pH intracellular chloride brain slices pH and Cl− transporters Ca2+ indicators calcium in vivo imaging place cells place fields cognitive maps ENaC phosphoinositides PIP2 optogenetic CRY2 sodium channel CoroNa Green azobenzene behavior brainwave dopamine GPCR in vivo electrophysiology photochromism photoswitch zebrafish neural plasticity tropomyosin kinase receptor B parvalbumin-positive interneurons calcium/calmodulin positive pyramidal neurons V1/visual cortex multiple regression with interaction and simple slopes analysis n/a thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences |
| url | ONIX_20230202_9783036565637_138 |