Animal Models for Study of Pathophysiological Mechanisms of Hypertension and Its Complications
Essential hypertension is still an important health care problem. It is necessary to investigate its mechanisms in animal models. The potential clinical importance of such experimental research might be expected. This Special Issue concerned several important topics. First, several studies focused o...
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| Μορφή: | Online |
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| Γλώσσα: | Αγγλικά |
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MDPI - Multidisciplinary Digital Publishing Institute
2023
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| Διαθέσιμο Online: | ONIX_20230202_9783036563183_167 |
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| collection | Directory of Open Access Books |
| description | Essential hypertension is still an important health care problem. It is necessary to investigate its mechanisms in animal models. The potential clinical importance of such experimental research might be expected. This Special Issue concerned several important topics. First, several studies focused on the pathophysiological mechanisms responsible for blood pressure elevation during hypertension development, organ damage in chronic hypertension, and drugs targeting hypertension and/or its complications. Other studies were interested in the participation of central and peripheral blood pressure control, changes in vascular structure and function, and neural, humoral, and endocrine factors. Furthermore, the contribution of altered redox signaling, chronic inflammation, microbiome changes, and interactions of genetic and environmental factors were evaluated in multiple papers. Finally, special attention was paid to the progress in pharmacological tools for the control of hypertension and associated organ damage, genetic modifications to alter blood pressure levels, and non-pharmacological interventions attenuating hypertension or its complications. The original articles or reviews covered the interesting aspects of the pathophysiology of hypertension and associated end-organ damage, the use of various experimental hypertensive models, and the importance of specific environmental factors acting in distinct phases of the ontogeny. We especially appreciate the presentation of new ideas and the critical discussion of traditional theories. |
| format | Online |
| id | doab-20.500.12854ir-96766 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2023 |
| publishDateRange | 2023 |
| publishDateSort | 2023 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-967662024-03-31T13:11:19Z Animal Models for Study of Pathophysiological Mechanisms of Hypertension and Its Complications Zicha, Josef Vaněčková, Ivana developmental origins of health and disease (DOHaD) gut microbiota hypertension short chain fatty acid oxidative stress probiotics prebiotics renin–angiotensin system fibroblast growth factor-23 left ventricular hypertrophy renin–angiotensin–aldosterone system losartan canrenone Hyp mice X-linked hypophosphatemia hairless SHRM cold acclimation cardiac Cx43 extracellular matrix thyroid hormones SHR sacubitril/valsartan ARNI ivabradine remodelling cardiac dysfunction fibrosis angiotensin II angiotensin 1-7 knock-out genome-editing SHRSP Dahl SS foetal programming of hypertension sympathetic neurotransmission sympathetic innervation vascular remodelling foetal undernutrition old SHR antihypertensive therapy blood pressure monitoring LV hypertrophy ECM markers cardiac fibrosis SHR-CRP SGLT-2 inhibitor gene expression age lipid metabolism nitric oxide l-NAME rostral ventrolateral medulla aging reactive oxygen species NADPH oxidase activator 1 mitochondria chloride calcium-activated chloride channel Na+–K+–2Cl− cotransporter 1 TMEM16A smooth muscle fetal undernutrition programming cross-fostering lactation period cardiovascular hypertrophy adipose tissue browning cardiovascular disease catecholamines liquid chromatography–tandem mass spectrometry SGLT-2 inhibition proteinuria uninephrectomized salt-loaded two-kidney one-clip hypertension fawn-hooded hypertensive rat ApoE KO apolipoprotein E knockout mice atherosclerosis Na,K-ATPase TCTP TCTP-overexpressing transgenic mice translationally controlled tumor protein TCTP-TG experimental hypertension bone rats taurine magnesium 24 h urine(24U) stroke-prone spontaneously hypertensive rat young SHR combination therapy treatment effect systolic blood pressure thema EDItEUR::M Medicine and Nursing thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJD Cardiovascular medicine Essential hypertension is still an important health care problem. It is necessary to investigate its mechanisms in animal models. The potential clinical importance of such experimental research might be expected. This Special Issue concerned several important topics. First, several studies focused on the pathophysiological mechanisms responsible for blood pressure elevation during hypertension development, organ damage in chronic hypertension, and drugs targeting hypertension and/or its complications. Other studies were interested in the participation of central and peripheral blood pressure control, changes in vascular structure and function, and neural, humoral, and endocrine factors. Furthermore, the contribution of altered redox signaling, chronic inflammation, microbiome changes, and interactions of genetic and environmental factors were evaluated in multiple papers. Finally, special attention was paid to the progress in pharmacological tools for the control of hypertension and associated organ damage, genetic modifications to alter blood pressure levels, and non-pharmacological interventions attenuating hypertension or its complications. The original articles or reviews covered the interesting aspects of the pathophysiology of hypertension and associated end-organ damage, the use of various experimental hypertensive models, and the importance of specific environmental factors acting in distinct phases of the ontogeny. We especially appreciate the presentation of new ideas and the critical discussion of traditional theories. 2023-02-02T16:48:51Z 2023-02-02T16:48:51Z 2023 book ONIX_20230202_9783036563183_167 9783036563183 9783036563190 https://directory.doabooks.org/handle/20.500.12854/96766 eng image/jpeg Attribution 4.0 International https://mdpi.com/books/pdfview/book/6712 https://mdpi.com/books/pdfview/book/6712 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-0365-6319-0 10.3390/books978-3-0365-6319-0 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783036563183 9783036563190 296 Basel open access |
| spellingShingle | developmental origins of health and disease (DOHaD) gut microbiota hypertension short chain fatty acid oxidative stress probiotics prebiotics renin–angiotensin system fibroblast growth factor-23 left ventricular hypertrophy renin–angiotensin–aldosterone system losartan canrenone Hyp mice X-linked hypophosphatemia hairless SHRM cold acclimation cardiac Cx43 extracellular matrix thyroid hormones SHR sacubitril/valsartan ARNI ivabradine remodelling cardiac dysfunction fibrosis angiotensin II angiotensin 1-7 knock-out genome-editing SHRSP Dahl SS foetal programming of hypertension sympathetic neurotransmission sympathetic innervation vascular remodelling foetal undernutrition old SHR antihypertensive therapy blood pressure monitoring LV hypertrophy ECM markers cardiac fibrosis SHR-CRP SGLT-2 inhibitor gene expression age lipid metabolism nitric oxide l-NAME rostral ventrolateral medulla aging reactive oxygen species NADPH oxidase activator 1 mitochondria chloride calcium-activated chloride channel Na+–K+–2Cl− cotransporter 1 TMEM16A smooth muscle fetal undernutrition programming cross-fostering lactation period cardiovascular hypertrophy adipose tissue browning cardiovascular disease catecholamines liquid chromatography–tandem mass spectrometry SGLT-2 inhibition proteinuria uninephrectomized salt-loaded two-kidney one-clip hypertension fawn-hooded hypertensive rat ApoE KO apolipoprotein E knockout mice atherosclerosis Na,K-ATPase TCTP TCTP-overexpressing transgenic mice translationally controlled tumor protein TCTP-TG experimental hypertension bone rats taurine magnesium 24 h urine(24U) stroke-prone spontaneously hypertensive rat young SHR combination therapy treatment effect systolic blood pressure thema EDItEUR::M Medicine and Nursing thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJD Cardiovascular medicine Animal Models for Study of Pathophysiological Mechanisms of Hypertension and Its Complications |
| title | Animal Models for Study of Pathophysiological Mechanisms of Hypertension and Its Complications |
| title_full | Animal Models for Study of Pathophysiological Mechanisms of Hypertension and Its Complications |
| title_fullStr | Animal Models for Study of Pathophysiological Mechanisms of Hypertension and Its Complications |
| title_full_unstemmed | Animal Models for Study of Pathophysiological Mechanisms of Hypertension and Its Complications |
| title_short | Animal Models for Study of Pathophysiological Mechanisms of Hypertension and Its Complications |
| title_sort | animal models for study of pathophysiological mechanisms of hypertension and its complications |
| topic | developmental origins of health and disease (DOHaD) gut microbiota hypertension short chain fatty acid oxidative stress probiotics prebiotics renin–angiotensin system fibroblast growth factor-23 left ventricular hypertrophy renin–angiotensin–aldosterone system losartan canrenone Hyp mice X-linked hypophosphatemia hairless SHRM cold acclimation cardiac Cx43 extracellular matrix thyroid hormones SHR sacubitril/valsartan ARNI ivabradine remodelling cardiac dysfunction fibrosis angiotensin II angiotensin 1-7 knock-out genome-editing SHRSP Dahl SS foetal programming of hypertension sympathetic neurotransmission sympathetic innervation vascular remodelling foetal undernutrition old SHR antihypertensive therapy blood pressure monitoring LV hypertrophy ECM markers cardiac fibrosis SHR-CRP SGLT-2 inhibitor gene expression age lipid metabolism nitric oxide l-NAME rostral ventrolateral medulla aging reactive oxygen species NADPH oxidase activator 1 mitochondria chloride calcium-activated chloride channel Na+–K+–2Cl− cotransporter 1 TMEM16A smooth muscle fetal undernutrition programming cross-fostering lactation period cardiovascular hypertrophy adipose tissue browning cardiovascular disease catecholamines liquid chromatography–tandem mass spectrometry SGLT-2 inhibition proteinuria uninephrectomized salt-loaded two-kidney one-clip hypertension fawn-hooded hypertensive rat ApoE KO apolipoprotein E knockout mice atherosclerosis Na,K-ATPase TCTP TCTP-overexpressing transgenic mice translationally controlled tumor protein TCTP-TG experimental hypertension bone rats taurine magnesium 24 h urine(24U) stroke-prone spontaneously hypertensive rat young SHR combination therapy treatment effect systolic blood pressure thema EDItEUR::M Medicine and Nursing thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJD Cardiovascular medicine |
| topic_facet | developmental origins of health and disease (DOHaD) gut microbiota hypertension short chain fatty acid oxidative stress probiotics prebiotics renin–angiotensin system fibroblast growth factor-23 left ventricular hypertrophy renin–angiotensin–aldosterone system losartan canrenone Hyp mice X-linked hypophosphatemia hairless SHRM cold acclimation cardiac Cx43 extracellular matrix thyroid hormones SHR sacubitril/valsartan ARNI ivabradine remodelling cardiac dysfunction fibrosis angiotensin II angiotensin 1-7 knock-out genome-editing SHRSP Dahl SS foetal programming of hypertension sympathetic neurotransmission sympathetic innervation vascular remodelling foetal undernutrition old SHR antihypertensive therapy blood pressure monitoring LV hypertrophy ECM markers cardiac fibrosis SHR-CRP SGLT-2 inhibitor gene expression age lipid metabolism nitric oxide l-NAME rostral ventrolateral medulla aging reactive oxygen species NADPH oxidase activator 1 mitochondria chloride calcium-activated chloride channel Na+–K+–2Cl− cotransporter 1 TMEM16A smooth muscle fetal undernutrition programming cross-fostering lactation period cardiovascular hypertrophy adipose tissue browning cardiovascular disease catecholamines liquid chromatography–tandem mass spectrometry SGLT-2 inhibition proteinuria uninephrectomized salt-loaded two-kidney one-clip hypertension fawn-hooded hypertensive rat ApoE KO apolipoprotein E knockout mice atherosclerosis Na,K-ATPase TCTP TCTP-overexpressing transgenic mice translationally controlled tumor protein TCTP-TG experimental hypertension bone rats taurine magnesium 24 h urine(24U) stroke-prone spontaneously hypertensive rat young SHR combination therapy treatment effect systolic blood pressure thema EDItEUR::M Medicine and Nursing thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJD Cardiovascular medicine |
| url | ONIX_20230202_9783036563183_167 |