The Pathophysiology of Preeclampsia and Eclampsia
Preeclampsia is a hypertensive disorder of pregnancy, diagnosed after the 20th week of gestation in women experiencing new-onset hypertension along with symptoms affecting the liver, kidneys, or brain. In some cases, women with preeclampsia develop novel seizures or unexplained coma, at which time t...
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| Formato: | Online |
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| Idioma: | inglés |
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MDPI - Multidisciplinary Digital Publishing Institute
2023
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| Acceso en liña: | ONIX_20230202_9783036564111_172 |
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| collection | Directory of Open Access Books |
| description | Preeclampsia is a hypertensive disorder of pregnancy, diagnosed after the 20th week of gestation in women experiencing new-onset hypertension along with symptoms affecting the liver, kidneys, or brain. In some cases, women with preeclampsia develop novel seizures or unexplained coma, at which time they are diagnosed with eclampsia. The mechanisms contributing to preeclampsia and eclampsia are not fully elucidated, although the placenta seems to play a critical role. Previous studies suggest that improper placentation stimulates mitochondrial dysfunction and the exaggerated release of placental-derived molecules including inflammatory cytokines, anti-angiogenic factors, reactive oxygen species, and cell-free nucleic acids into the maternal circulation that cause systemic vascular dysfunction. These, along with maternally derived molecules, act in concert, leading to hypertension and target organ damage during pregnancies complicated by preeclampsia and eclampsia.In this reprint, we present the original research articles and review papers published as part of the Special Issue: "The Pathophysiology of Preeclampsia and Eclampsia" in Cells. |
| format | Online |
| id | doab-20.500.12854ir-96771 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2023 |
| publishDateRange | 2023 |
| publishDateSort | 2023 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-967712024-03-30T23:21:31Z The Pathophysiology of Preeclampsia and Eclampsia Warrington, Junie P Palei, Ana T. Cunningham, Mark W. Amaral, Lorena M. pre-eclampsia eclampsia pulmonary oedema biobank database placental ischemia seizure ASIC2a pregnancy RUPP pentylenetetrazol melatonin extracellular vesicle exosome preeclampsia misfold proteins endothelial cell activation p21Cip1/CDKN1A trophoblasts hypoxia trophoblast organoids fusion angiotensin II AGTR1 (angiotensin II receptor type 1) bradykinin BDKRB2 (bradykinin receptor B2) AT1R-B2R heteromer (protein complex formed of AT1R-B2R) G-protein-coupled receptor protein aggregation ARRB (beta-arrestin) early-onset preeclampsia hemorheology red blood cell aggregation red blood cell deformability erythrocyte hypertension IL-2 inflammation oxidative stress sFlt-1 NLRP3 nitric oxide endothelial dysfunction neuroinflammation blood–brain barrier cerebral edema gestation vessel blood pressure placenta trophoblast fetal growth restriction maternal chronic venous disease (CVeD) anti-inflammation antioxidant ischaemia vitamin E glucose transporter 9 GLUT9 uric acid cardiac dysfunction placental factors activin A G-protein-coupled receptors GPCR weighted gene correlation network analysis WGCNA blood-brain barrier in vitro studies cerebral biomarkers NfL tau NSE S100B nebivolol adrenoceptor obesity biomarkers adipokines adiponectin leptin ROS angiogenic factors hypoxia/reoxygenation sFlT-1/PlGF ratio primary trophoblast thema EDItEUR::M Medicine and Nursing Preeclampsia is a hypertensive disorder of pregnancy, diagnosed after the 20th week of gestation in women experiencing new-onset hypertension along with symptoms affecting the liver, kidneys, or brain. In some cases, women with preeclampsia develop novel seizures or unexplained coma, at which time they are diagnosed with eclampsia. The mechanisms contributing to preeclampsia and eclampsia are not fully elucidated, although the placenta seems to play a critical role. Previous studies suggest that improper placentation stimulates mitochondrial dysfunction and the exaggerated release of placental-derived molecules including inflammatory cytokines, anti-angiogenic factors, reactive oxygen species, and cell-free nucleic acids into the maternal circulation that cause systemic vascular dysfunction. These, along with maternally derived molecules, act in concert, leading to hypertension and target organ damage during pregnancies complicated by preeclampsia and eclampsia.In this reprint, we present the original research articles and review papers published as part of the Special Issue: "The Pathophysiology of Preeclampsia and Eclampsia" in Cells. 2023-02-02T16:49:48Z 2023-02-02T16:49:48Z 2023 book ONIX_20230202_9783036564111_172 9783036564111 9783036564104 https://directory.doabooks.org/handle/20.500.12854/96771 eng image/jpeg Attribution 4.0 International https://mdpi.com/books/pdfview/book/6717 https://mdpi.com/books/pdfview/book/6717 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-0365-6410-4 10.3390/books978-3-0365-6410-4 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783036564111 9783036564104 334 Basel open access |
| spellingShingle | pre-eclampsia eclampsia pulmonary oedema biobank database placental ischemia seizure ASIC2a pregnancy RUPP pentylenetetrazol melatonin extracellular vesicle exosome preeclampsia misfold proteins endothelial cell activation p21Cip1/CDKN1A trophoblasts hypoxia trophoblast organoids fusion angiotensin II AGTR1 (angiotensin II receptor type 1) bradykinin BDKRB2 (bradykinin receptor B2) AT1R-B2R heteromer (protein complex formed of AT1R-B2R) G-protein-coupled receptor protein aggregation ARRB (beta-arrestin) early-onset preeclampsia hemorheology red blood cell aggregation red blood cell deformability erythrocyte hypertension IL-2 inflammation oxidative stress sFlt-1 NLRP3 nitric oxide endothelial dysfunction neuroinflammation blood–brain barrier cerebral edema gestation vessel blood pressure placenta trophoblast fetal growth restriction maternal chronic venous disease (CVeD) anti-inflammation antioxidant ischaemia vitamin E glucose transporter 9 GLUT9 uric acid cardiac dysfunction placental factors activin A G-protein-coupled receptors GPCR weighted gene correlation network analysis WGCNA blood-brain barrier in vitro studies cerebral biomarkers NfL tau NSE S100B nebivolol adrenoceptor obesity biomarkers adipokines adiponectin leptin ROS angiogenic factors hypoxia/reoxygenation sFlT-1/PlGF ratio primary trophoblast thema EDItEUR::M Medicine and Nursing The Pathophysiology of Preeclampsia and Eclampsia |
| title | The Pathophysiology of Preeclampsia and Eclampsia |
| title_full | The Pathophysiology of Preeclampsia and Eclampsia |
| title_fullStr | The Pathophysiology of Preeclampsia and Eclampsia |
| title_full_unstemmed | The Pathophysiology of Preeclampsia and Eclampsia |
| title_short | The Pathophysiology of Preeclampsia and Eclampsia |
| title_sort | pathophysiology of preeclampsia and eclampsia |
| topic | pre-eclampsia eclampsia pulmonary oedema biobank database placental ischemia seizure ASIC2a pregnancy RUPP pentylenetetrazol melatonin extracellular vesicle exosome preeclampsia misfold proteins endothelial cell activation p21Cip1/CDKN1A trophoblasts hypoxia trophoblast organoids fusion angiotensin II AGTR1 (angiotensin II receptor type 1) bradykinin BDKRB2 (bradykinin receptor B2) AT1R-B2R heteromer (protein complex formed of AT1R-B2R) G-protein-coupled receptor protein aggregation ARRB (beta-arrestin) early-onset preeclampsia hemorheology red blood cell aggregation red blood cell deformability erythrocyte hypertension IL-2 inflammation oxidative stress sFlt-1 NLRP3 nitric oxide endothelial dysfunction neuroinflammation blood–brain barrier cerebral edema gestation vessel blood pressure placenta trophoblast fetal growth restriction maternal chronic venous disease (CVeD) anti-inflammation antioxidant ischaemia vitamin E glucose transporter 9 GLUT9 uric acid cardiac dysfunction placental factors activin A G-protein-coupled receptors GPCR weighted gene correlation network analysis WGCNA blood-brain barrier in vitro studies cerebral biomarkers NfL tau NSE S100B nebivolol adrenoceptor obesity biomarkers adipokines adiponectin leptin ROS angiogenic factors hypoxia/reoxygenation sFlT-1/PlGF ratio primary trophoblast thema EDItEUR::M Medicine and Nursing |
| topic_facet | pre-eclampsia eclampsia pulmonary oedema biobank database placental ischemia seizure ASIC2a pregnancy RUPP pentylenetetrazol melatonin extracellular vesicle exosome preeclampsia misfold proteins endothelial cell activation p21Cip1/CDKN1A trophoblasts hypoxia trophoblast organoids fusion angiotensin II AGTR1 (angiotensin II receptor type 1) bradykinin BDKRB2 (bradykinin receptor B2) AT1R-B2R heteromer (protein complex formed of AT1R-B2R) G-protein-coupled receptor protein aggregation ARRB (beta-arrestin) early-onset preeclampsia hemorheology red blood cell aggregation red blood cell deformability erythrocyte hypertension IL-2 inflammation oxidative stress sFlt-1 NLRP3 nitric oxide endothelial dysfunction neuroinflammation blood–brain barrier cerebral edema gestation vessel blood pressure placenta trophoblast fetal growth restriction maternal chronic venous disease (CVeD) anti-inflammation antioxidant ischaemia vitamin E glucose transporter 9 GLUT9 uric acid cardiac dysfunction placental factors activin A G-protein-coupled receptors GPCR weighted gene correlation network analysis WGCNA blood-brain barrier in vitro studies cerebral biomarkers NfL tau NSE S100B nebivolol adrenoceptor obesity biomarkers adipokines adiponectin leptin ROS angiogenic factors hypoxia/reoxygenation sFlT-1/PlGF ratio primary trophoblast thema EDItEUR::M Medicine and Nursing |
| url | ONIX_20230202_9783036564111_172 |