Chagas Disease
Even 110 years after its discovery, Chagas disease is still an important public health problem, especially in Latin America where it is endemic. The limited effect of current treatments in the chronic phase of the disease, as well as the lack of information about disease progression, are crucial cha...
Đã lưu trong:
| Định dạng: | Online |
|---|---|
| Ngôn ngữ: | Tiếng Anh |
| Được phát hành: |
IntechOpen
2023
|
| Những chủ đề: | |
| Truy cập trực tuyến: | ONIX_20230215_9781803556918_44 |
| Các nhãn: |
Không có thẻ, Là người đầu tiên thẻ bản ghi này!
|
| _version_ | 1869528110671593472 |
|---|---|
| collection | Directory of Open Access Books |
| description | Even 110 years after its discovery, Chagas disease is still an important public health problem, especially in Latin America where it is endemic. The limited effect of current treatments in the chronic phase of the disease, as well as the lack of information about disease progression, are crucial challenges that justify the intense research on this illness. The interaction between the etiological agent Trypanosoma cruzi and its invertebrate and vertebrate hosts involves the regulation of the parasite virulence and host immune responses. T. cruzi presents mechanisms to evade host defenses, including resistance to oxidative species and vesicles secretion, among many others. In this context, a better understanding of the biochemical and molecular features of the parasite’s success inside its hosts could contribute to the development of novel anti-T. cruzi strategies such as prototypes of drugs and vaccines. This book discusses Chagas disease and its etiological agent, including information on relevant clinical aspects such as diagnosis, treatment, biomarkers, and so on. It also presents information about cellular, molecular, and biochemical characteristics of the parasite-host interactions. |
| format | Online |
| id | doab-20.500.12854ir-97004 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2023 |
| publishDateRange | 2023 |
| publishDateSort | 2023 |
| publisher | IntechOpen |
| publisherStr | IntechOpen |
| record_format | ojs |
| spelling | doab-20.500.12854ir-970042024-03-31T22:45:46Z Chagas Disease Menna-Barreto, Rubem Clinical & internal medicine thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCJ Infectious and contagious diseases Even 110 years after its discovery, Chagas disease is still an important public health problem, especially in Latin America where it is endemic. The limited effect of current treatments in the chronic phase of the disease, as well as the lack of information about disease progression, are crucial challenges that justify the intense research on this illness. The interaction between the etiological agent Trypanosoma cruzi and its invertebrate and vertebrate hosts involves the regulation of the parasite virulence and host immune responses. T. cruzi presents mechanisms to evade host defenses, including resistance to oxidative species and vesicles secretion, among many others. In this context, a better understanding of the biochemical and molecular features of the parasite’s success inside its hosts could contribute to the development of novel anti-T. cruzi strategies such as prototypes of drugs and vaccines. This book discusses Chagas disease and its etiological agent, including information on relevant clinical aspects such as diagnosis, treatment, biomarkers, and so on. It also presents information about cellular, molecular, and biochemical characteristics of the parasite-host interactions. 2023-02-15T14:34:15Z 2023-02-15T14:34:15Z 2022 book ONIX_20230215_9781803556918_44 9781803556918 9781803556901 9781803556925 https://directory.doabooks.org/handle/20.500.12854/97004 eng image/jpeg n/a https://www.intechopen.com/books/11377 https://mts.intechopen.com/storage/books/11377/authors_book/authors_book.pdf IntechOpen IntechOpen 10.5772/intechopen.98175 10.5772/intechopen.98175 78a36484-2c0c-47cb-ad67-2b9f5cd4a8f6 9781803556918 9781803556901 9781803556925 IntechOpen 182 open access |
| spellingShingle | Clinical & internal medicine thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCJ Infectious and contagious diseases Chagas Disease |
| title | Chagas Disease |
| title_full | Chagas Disease |
| title_fullStr | Chagas Disease |
| title_full_unstemmed | Chagas Disease |
| title_short | Chagas Disease |
| title_sort | chagas disease |
| topic | Clinical & internal medicine thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCJ Infectious and contagious diseases |
| topic_facet | Clinical & internal medicine thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCJ Infectious and contagious diseases |
| url | ONIX_20230215_9781803556918_44 |